The role of interleukin -1 family in fibrotic diseases

Wang, Haoran; Wu, Jerry J.; Li, Ma; Bai, Yunfeng; Li, Jun

doi:10.1016/j.cyto.2023.156161

Cited by 6 publications

(7 citation statements)

References 102 publications

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“…They are involved in the onset and development of many fibrotic diseases. 23 Also, Interleukin-1 is involved in pathogenic pathways and is a therapeutic target for inflammation in heart disease. 24 Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that has been suggested to be involved in cardiac remodelling after ischaemia and impairment in ventricular contractility and relaxation.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Inflammatory Cytokines in Predicting Hospital Readmissions in Heart Failure with Preserved Ejection Fraction

Zhao,

Qi,

Zhang

et al. 2024

JIR

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The aim of this study was to explore the relationship between inflammatory cytokines and the risk of heart failure (HF) readmission in patients with heart failure with preserved ejection fraction (HFpEF). Patients and Methods: We enrolled 429 patients with HFpEF admitted to the cardiology department in our hospital from January 2020 to July 2022. The patients were divided into the readmission or non-readmission groups according to whether they were readmitted for heart failure within 1 year of discharge. The clinical features and laboratory date of the subjects were collected and analyzed. Multivariate cox regression analysis was used to identify predictors of HF readmission. In addition, receiver operating characteristic (ROC) curves were used to determine the prognostic value of each factor. Results: The levels of IL-1β, IL-6, IL-10, IL-17, TNF-α, NT-proBNP, heart rate, total cholesterol and NYHA class were significantly higher in the readmission group than in the non-readmission group (p < 0.05). IL-1β, IL-6, IL-17, TNF-α, NT-proBNP, heart rate and NYHA class were identified as independent predictors of HF readmission. Conclusion: Inflammatory markers, including IL-1β, IL-6, IL-17 and TNF-α were related to the HF readmission in patients with HFpEF.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Inflammatory Cytokines in Predicting Hospital Readmissions in Heart Failure with Preserved Ejection Fraction

Zhao,

Qi,

Zhang

et al. 2024

JIR

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“…In an animal model of renal ischemiareperfusion injury, macrophages that in ltrate the kidney express elevated levels of THBS1, contributing to tubular damage 44 . Other genes highly expressed in THBS1_Mac, such as LRG1 25 and IL1B 24 , are also implicated in renal damage. Given these ndings, the THBS1_Mac subset, differentiated from CD14_EGR1, may contribute to vascular and tubular damage, potentially explaining the pathogenesis of acute kidney injury in SRC.…”

Section: Discussionmentioning

confidence: 99%

“…4d. In the THBS1_Mac subset, genes linked to vascular injury and brosis, such as THBS1 23 , IL1B 24 , and LRG1 25 , were highly expressed. DEGs were identi ed in the THBS1_Mac subset compared to other myeloid cell subpopulations (Supplementary Table 6), and subsequent pathway analysis revealed an enrichment of the "Interleukin-1 regulation of extracellular matrix" pathway in this subset (Extended Data Fig.…”

Section: Pathological Role Of Cd14_egr1 Monocytes In Tissue Damage Me...mentioning

confidence: 99%

Single-cell analysis reveals immune cell abnormalities underlying the clinical heterogeneity of systemic sclerosis

Nishide,

Shimagami,

Nishimura

et al. 2024

Preprint

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Autoimmune rheumatic diseases present with diverse clinical manifestations that often complicate management strategies. Systemic sclerosis (SSc) is a representative disease with multiple organ manifestations affecting patients worldwide, and exploring the variation of immune abnormalities in this disease is of great interest. However, previous studies have focused on diseased tissues, and it remains largely unknown how cellular diversity links to clinical heterogeneity. Here, we perform single-cell transcriptome and surface proteome analyses of peripheral blood mononuclear cells (PBMCs) from 21 SSc patients who are not receiving immunomodulatory therapy and show that different clinical manifestations are associated with distinct immune abnormalities. Enrichment of a specific CD14+ monocyte subset characterized by EGR1 expression is observed in patients with scleroderma renal crisis (SRC). Integrated analysis of PBMCs and kidney biopsy cells indicates that this monocyte subset directly differentiates into tissue-damaging macrophages under activation of NF-κB signaling. Clinically, EGR1 expression in monocytes is significantly upregulated at the onset of SRC and decreases after treatment, suggesting its potential as a biomarker for SRC. In patients with interstitial lung disease (ILD), a CD8+ T cell subset with type II interferon signature is highly enriched in both peripheral blood and lung tissue of patients with progressive disease, suggesting that chemokine-driven migration of these cells is involved in ILD progression. Thus, distinct immune cell profiles at the single cell level reveal different directions of immune dysregulation between organ manifestations and provide insights for tailored treatment strategies.

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“…The IL-1 family of cytokines is involved in the occurrence and progression of diverse fibrotic diseases. Consequently, their biology, association with diseases, and clinical applications have attracted interest worldwide[ 26 ]. Eleven cytokines and ten receptors have been identified in the IL-1 family[ 26 ].…”

Section: Liver Diseases Comorbidities and Conditionsmentioning

confidence: 99%

Interleukin-mediated therapies in liver diseases and comorbidity effects

Bouare,

Delwaide

2024

World J Hepatol

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Cytokines like interleukins (ILs) play important roles in inflammation and innate immune. Yang and Zhang carried out an interesting study related to ILs and hepatic diseases. They described the role of ILs in the pathogenesis and resolution of hepatic disorders. The authors summarized alcohol-related liver disease and virus-induced hepatitis, as far as clinical studies a fortiori carried out on IL-mediated treatments pertaining to these dysfunctions. This editorial contributes to the review by Yang and Zhang titled, "Interleukins in liver disease treatment", and focuses on therapies mediated by ILs in comorbid liver diseases. The documentary search was conducted on recent pertinent literature, primarily using the Google Scholar and PubMed databases.

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The role of interleukin -1 family in fibrotic diseases

Cited by 6 publications

References 102 publications

Prognostic Value of Inflammatory Cytokines in Predicting Hospital Readmissions in Heart Failure with Preserved Ejection Fraction

Prognostic Value of Inflammatory Cytokines in Predicting Hospital Readmissions in Heart Failure with Preserved Ejection Fraction

Single-cell analysis reveals immune cell abnormalities underlying the clinical heterogeneity of systemic sclerosis

Interleukin-mediated therapies in liver diseases and comorbidity effects

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