The role of inner border sign and ridge sign in detecting high-grade cervical intraepithelial neoplasia

Grigore, Mihaela; Cojocaru, Cristian; Teleman, S

doi:10.18203/2320-1770.ijrcog20163834

Cited by 1 publication

(3 citation statements)

References 11 publications

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“…The high specificity and low sensitivity found in our study are similar to the results of studies that evaluated the performance of two specific images, inner border sign and ridge sign, for the diagnosis of CIN 2 and 3 [18][19][20]. These images were introduced in the current colposcopy terminology of IFCPC 9 due to the evidence that they represent relevant signs for the identification of CIN 2 and 3 [19,21].…”

Section: Discussionsupporting

confidence: 85%

“…Thereupon colposcopy performance should be considered an evolving process. Furthermore, both the description and evaluation of image patterns, in our study and in previous ones [18][19][20], are relevant for achieving the goal of improving specificity of colposcopy.…”

Section: Discussionmentioning

confidence: 81%

“…Nevertheless, none of the aforementioned studies [18][19][20]22] involved assessing colposcopy performance for the diagnosis of glandular cervical precursor neoplasias. Conversely, they all added up to several other studies to demonstrate the high specificity of colposcopy [9,[18][19][20]23], in line with the findings of this study.…”

Section: Discussionmentioning

confidence: 99%

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Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias

Fachetti-Machado

Alves

Moreira

2021

Arch Gynecol Obstet

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Purpose To evaluate prevalence and diagnostic performance of three colposcopic images to diagnose squamous and glandular cervical precursor neoplasias. Methods Cross-sectional study, conducted through analysis of stored digital colposcopic images. To evaluate the diagnostic performance of three images, herein named grouped glands, aceto-white villi, and atypical vessels, for detection of adenocarcinoma in situ (AIS) and cervical squamous intraepithelial neoplasias (CIN) grades 2 and 3, calculations of sensitivity, specificity, accuracy, positive likelihood ratio, receiver operating characteristic (ROC) curve, and area under the curve (AUC) were made, with their respective 95% confidence intervals. Results Grouped glands, aceto-white villi, and atypical vessels images had: prevalence of 21.3, 53.8, and 33.8% in patients with AIS, and 16.2, 19.5, and 9.3% in those with CIN 2 and 3; for the diagnosis of AIS, sensitivity of 21.3, 53.8, and 33.8%, specificity of 89.8, 95.2, and 94.9%, accuracy of 76.6, 87.2, and 83.1%, positive likelihood ratio of 2.1, 11.2, and 6.6, and AUC of 0.55, 0.74, and 0.64; for the diagnosis of CIN 2 and 3, sensitivity of 16.2, 19.5, and 9.3%, specificity of 89.8, 95.2, and 94.9%, accuracy of 39.4, 43.4, and 36.3%, positive likelihood ratio of 1.6, 4.1, and 1, 8, and AUC of 0.53, 0.57, and 0.52, respectively. Conclusion Prevalence and accuracy of the three images were higher for the diagnosis of glandular than squamous cervical precursor neoplasias. Sensitivity, specificity, positive likelihood, and AUC of aceto-white villi and atypical vessels images were higher for the diagnosis of glandular than squamous cervical precursor neoplasias.

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