The Role of Innate Immunity in Osteoarthritis and the Connotation of
"Immune-joint" Axis: A Narrative Review
Gaoyan Kuang,
Xuyi Tan,
Xin Liu
et al.
Abstract:Osteoarthritis (OA) is a degenerative disease that results in constriction of the joint
space due to the gradual deterioration of cartilage, alterations in subchondral bone, and synovial
membrane. Recently, scientists have found that OA involves lesions in the whole joint, in addition
to joint wear and tear and cartilage damage. Osteoarthritis is often accompanied by a subclinical
form of synovitis, which is a chronic, relatively low-grade inflammatory response mainly
mediated by the innate immune system. The … Show more
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