The Role of Inhibin on Pituitary FSH Secretion and Maturation of Pituitary-Gonadal Axis in Immature Female Rats.

Fukaya, Takao; Kakuta, Chieko; Tozawa, Hideo; Mansfield, Charles; Tsuiki, Akira; Yohkaichiya, Takashi; Yajima, Akira

doi:10.1620/tjem.170.1

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…In this study, we did not investigate the expression of the inhibin ␣ subunit, which combines with the ␤ subunits to form inhibin. Previous studies have suggested that inhibin is not TC # 244 physiologically important in FSH regulation before PND 20 [23,24]. Since the ␤ subunit forms a dimer with the ␣ subunit to form the inhibin molecules, it remains possible that the level of ␣ subunit expression relative to ␤ subunits could modulate the amount of the ␤ dimers present, and thus the amount of biologically active activin.…”

Section: Discussionmentioning

confidence: 99%

Activin Subunit, Follistatin, and Activin Receptor Gene Expression in the Prepubertal Female Rat Pituitary1

Wilson

1998

Biology of Reproduction

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In the prepubertal female rat, a transient and selective increase in FSH secretion and mRNA expression by the pituitary gland occurs toward the end of the second postnatal week of life. To begin to investigate the possibility that activin may play a role in up-regulating FSH during this time, we have studied the ontogeny of the expression of the activin ss subunits, follistatin, and activin receptor subtypes in the prepubertal female rat pituitary. The levels of expression of ssA, ssB, and follistatin mRNAs were determined in the pituitary gland on postnatal days (PND) 8, 10, 12, 15, and 21 by semiquantitative reverse transcription-polymerase chain reaction. All values were compared to those of adult females killed on diestrus. mRNA levels of subunit ssA were significantly (p < 0.05) elevated on all postnatal days examined; ssB mRNA levels were elevated above adult levels only on PND 10 (p < 0.05). Follistatin mRNA was high on PND 8 (p < 0.05) and then decreased to adult levels. The level and distribution of activin receptor type II subtype mRNAs were determined by in situ hybridization. Activin receptor type II (Act RII) mRNA expression was diffusely expressed throughout all areas of the pituitary. Activin receptor type IIB (Act RIIB), on the other hand, was highly expressed by a subset of anterior pituitary cells. In situ hybridization for activin receptor subtype mRNAs was combined with immunocytochemistry to detect FSH-containing cells. We determined that in the infantile female pituitary, Act RII mRNA was generally not expressed in FSH-immunoreactive cells, while Act RIIB mRNA was expressed in FSH-immunoreactive cells. Act RII mRNA was lower on PND 10 and 15 when compared to PND 21 (p < 0.05), whereas Act RIIB mRNA expression did not change with age. These data suggest that the essential components of the activin regulatory system are present in the infantile female pituitary gland and thus may be involved in the differential regulation of FSH at this time.

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Section: Discussionmentioning

confidence: 99%

Activin Subunit, Follistatin, and Activin Receptor Gene Expression in the Prepubertal Female Rat Pituitary1

Wilson

1998

Biology of Reproduction

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New Insights of Inhibins in Ovarian Physiology of Fish

Ahmad

Bhat

Jagtap

et al. 2020

Reviews in Fisheries Science & Aquaculture

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Inhibin and premature ovarian failure

Chand¹,

Harrison²,

Shelling

2009

Human Reproduction Update

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The identification of an autosomal mutation in the inhibin alpha subunit gene that is significantly linked to POF in certain ethnic populations highlights the role of inhibin in the regulation of ovarian biology and fertility. Although the reduction of inhibin B bioactivity by the INHA G769A mutation is clearly not the only cause, evidence suggests that this change may serve as a susceptibility factor, increasing the likelihood of POF.

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The Role of Inhibin on Pituitary FSH Secretion and Maturation of Pituitary-Gonadal Axis in Immature Female Rats.

Cited by 4 publications

References 22 publications

Activin Subunit, Follistatin, and Activin Receptor Gene Expression in the Prepubertal Female Rat Pituitary1

Activin Subunit, Follistatin, and Activin Receptor Gene Expression in the Prepubertal Female Rat Pituitary1

New Insights of Inhibins in Ovarian Physiology of Fish

Inhibin and premature ovarian failure

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