The Role of Information Processing Speed in Clinical and Social Support Variables of Patients with Multiple Sclerosis

Eizaguirre, María Bárbara; Vanotti, Sandra; Merino, Angeles; Yastremiz, Cecilia; Silva, Berenice; Alonso, Ricardo; Garcea, Orlando

doi:10.3988/jcn.2018.14.4.472

Cited by 35 publications

(16 citation statements)

References 43 publications

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“…The reduced response strength of the last three questions in the higher EDSS ranges could explain why the MSNQ performs worse as a cognitive screening measure in the higher EDSS ranges. Our second hypothesis to explain the worse performance of the MSNQ in the higher EDSS ranges related to the overestimation of cognitive functioning, resulting in lower MSNQ scores, being associated with more severe cognitive impairment, 22 more frequently seen in the higher EDSS ranges. 22,23 The inverse correlation between MSNQ and EDSS scores observed in the high EDSS group only supports this explanation.…”

Section: Discussionmentioning

confidence: 97%

“…Our second hypothesis to explain the worse performance of the MSNQ in the higher EDSS ranges related to the overestimation of cognitive functioning, resulting in lower MSNQ scores, being associated with more severe cognitive impairment, 22 more frequently seen in the higher EDSS ranges. 22,23 The inverse correlation between MSNQ and EDSS scores observed in the high EDSS group only supports this explanation. In case of an accurate patient-reported assessment of cognition, we would have expected a positive correlation due to the presumably higher prevalence of CI in higher EDSS ranges.…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, when assessing discrepancies between self- and informant-reported cognitive performance with the MSNQ, overestimators performed worse on neuropsychological test batteries than underestimators and accurate estimators. 21 Since higher EDSS scores have been associated with an increased risk of objective cognitive decline, 22,23 overestimating cognitive performance when completing the patient-report MSNQ, resulting in lower MSNQ scores, can be expected to occur in a higher proportion of patients with moderate to severe disability.…”

Section: Introductionmentioning

confidence: 99%

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Correlates of patient-reported cognitive performance with regard to disability

Laethem

Cock

Schependom

et al. 2021

Preprint

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Background: The inconsistent association of patient−reported Multiple Sclerosis Neuropsychological Questionnaire (MSNQ) scores with performance−based cognitive tests in MS could be related to the degree of disability, due to certain MSNQ−questions assuming some self−dependence and intact instrumental ADLs. Objectives: To test whether the relation between subjective and objective cognitive performance could be moderated by physical disability as measured by the Expanded Disability Status Scale (EDSS), we assessed the correlation between MSNQ and Symbol Digit Modalities Test (SDMT) scores in different EDSS groups. Methods: From 288 MS patients who completed the patient−report MSNQ and a two−question screening tool for depression, we also collected SDMT and EDSS scores. We analysed correlations in the total group and three EDSS subgroups: Low 0.0 − 3.0, Medium 3.5 − 6.0 and High 6.5 − 9.5. Results: We found a significant and negative correlation between patient−reported MSNQ scores and SDMT scores in the low EDSS (r = −.225, p = .044), but not in the medium and high EDSS groups, and significant positive correlations between MSNQ and depression in all subgroups. Conclusions: Our data suggest that the patient−report MSNQ has potential as a measure of cognition in patients with low EDSS-scores but not in the medium and high EDSS ranges.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Correlates of patient-reported cognitive performance with regard to disability

Laethem

Cock

Schependom

et al. 2021

Preprint

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“…Slowed CPS, generally the first cognitive deficit to emerge in persons with MS (PwMS) (Van Schependom et al, 2015), may underlie other cognitive dysfunctions (Costa et al, 2017). It is associated with decreased quality of life, interference with everyday tasks, depression, and unemployment (Barker-Collo, 2006;Clemens and Langdon, 2018;Eizaguirre et al, 2018). The Symbol Digit Modalities Test (SDMT) is a preferred measure of CPS for MS trials and routine screening (Drake et al, 2010;Strober et al, 2019;Kalb et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effect of Ozanimod on Symbol Digit Modalities Test Performance in Relapsing MS

DeLuca

Schippling

Montalbán

et al. 2021

Multiple Sclerosis and Related Disorders

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Background: Cognitive dysfunction, including slowed cognitive processing speed (CPS), is one of the most disabling symptoms of multiple sclerosis (MS). The Symbol Digit Modalities Test (SDMT) is a preferred measure of CPS for MS trials and routine screening. Based on encouraging SDMT results in the phase 3 SUNBEAM trial, these post hoc, exploratory analyses were conducted to further compare effects of the sphingosine 1-phosphate receptor modulator ozanimod versus intramuscular interferon β-1a on CPS in participants with relapsing multiple sclerosis (RMS). Methods: In the phase 3, double-blind, double-dummy, SUNBEAM study, adults (aged 18-55 years) with RMS (N=1,346) were randomized to once-daily oral ozanimod 0.92 or 0.46 mg, or weekly intramuscular interferon β-1a 30 µg. The study continued until the last participant was treated for 12 months. CPS was measured as part of a secondary endpoint using the SDMT. Exploratory, post hoc analyses evaluated SDMT change and percentages of participants with clinically meaningful (≥4-point) SDMT improvement or worsening at months 6 and 12, and relationship between SDMT and brain volume on magnetic resonance imaging. Results: Ozanimod improved SDMT scores compared with interferon β-1a at months 6 and 12. At month 12, least squares mean difference in SDMT z-scores for ozanimod 0.92 mg versus interferon β-1a was 0.102 (95% CI, 0.031-0.174, nominal p = 0.0051; standardized mean difference = 0.1376). A greater percentage of ozanimod 0.92 mg-treated participants had clinically meaningful improvements in SDMT scores versus interferon β-1a at month 6 (30.0% versus 22.2%) and month 12 (35.6% versus 27.9%). Of those with SDMT improvement at month 6, 66.4% of those treated with ozanimod 0.92 mg and 55.9% of those treated with interferon β-1a had sustained Statistician: Hongjuan Liu, Bristol Myers Squibb, Princeton, New Jersey. Nonstandard abbreviations: CPS = cognitive processing speed; PwMS = persons with multiple sclerosis; SMD = standardized mean differences.

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“…Dabei bekommt der Proband die Aufgabe, auf einen definierten Zielreiz eine definierte Zielreaktion zu zeigen. Es werden keine ablenkenden Reize dargeboten und der Proband muss nicht zwischen verschiedenen Zielreaktionen wählen[8].DasGedächtnis wird in der Kognitionspsychologie klassischerweise nach dem chronologischen Ablauf der Verarbeitung eingehender Informationen differenziert. Das Kurzzeitgedächtnis hält eine begrenzte Menge von Informationen (5-9 Elemente) für bis zu etwa 30 Sekunden in einem unmittelbar bewusst verfügbaren Zustand bereit.…”

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Kognitionspsychologische Grundlagen und häufige methodische Fallstricke bei der Erforschung sport- und bewegungsinduzierter Effekte auf kognitive Leistungen

Oberste

Zimmer

2020

B & G

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ZusammenfassungIm Rahmen von neurodegenerativen und psychiatrischen Erkrankungen, als Folge von medizinischen Behandlungen (z. B. mit neurotoxischen Zytostatika) sowie im normalen Altersgang werden kognitive Leistungsminderungen beschrieben. Neben vielen anderen positiven Effekten von Sport und Bewegung scheinen diese sich auch positiv auf das zentrale Nervensystem auszuwirken. Das wissenschaftliche und klinische Interesse an Sport- und Bewegungsinterventionen, die auf eine Linderung kognitiver Symptome zielen, fordert von Sportwissenschaftlern sowie Sport- und Bewegungstherapeuten Kenntnisse im Umgang mit und bei der Interpretation kognitiver Leistungstests. Neben denen in der Klinik häufig eingesetzten Kurztests zur Beurteilung der globalen kognitiven Leistungsfähigkeit, die z. B. Hinweise auf eine beginnende Demenz geben können, werden in der Forschung sehr spezifische Testverfahren genutzt, um spezifische kognitiven Subdomänen zu beurteilen. Das macht ein Verständnis der Abgrenzungen zwischen kognitiven Funktionsbereichen und Subdomänen für die Interpretation der Testergebnisse essenziell. Im vorliegenden Artikel wird ein Überblick über kognitionspsychologische Taxonomien gegeben. Bei der Auswahl geeigneter Testverfahren kann auf bestehende, etablierte Testbatterien aus den medizinischen Fachbereichen der betreffenden Patientenpopulation zurückgegriffen werden. Hierzu werden einige verbreitete Testbatterien exemplarisch genannt. Die Gültigkeit der Ergebnisse von Untersuchungen zu den Effekten von Sport und Bewegung auf kognitive Leistungen kann durch Lerneffekte und Unterschiede zwischen den Versuchsgruppen hinsichtlich Zuwendung durch die Versuchsleiter (Hawthorne-Effekt) und / oder Erwartungen der Patienten hinsichtlich kognitiver Benefits (Placebo-Effekte) gefährdet sein. Es werden methodische Maßnahmen vorgestellt, durch die diese Gefährdungen der Validität reduziert bzw. vermieden werden können.

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The Role of Information Processing Speed in Clinical and Social Support Variables of Patients with Multiple Sclerosis

Cited by 35 publications

References 43 publications

Correlates of patient-reported cognitive performance with regard to disability

Correlates of patient-reported cognitive performance with regard to disability

Effect of Ozanimod on Symbol Digit Modalities Test Performance in Relapsing MS

Kognitionspsychologische Grundlagen und häufige methodische Fallstricke bei der Erforschung sport- und bewegungsinduzierter Effekte auf kognitive Leistungen

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