The role of inflammatory parameters (neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and monocyte‐to‐eosinophil ratio) in patients with Peyronie's disease

Abstract

Objectives The aim of the study was to investigate the ability of the systemic inflammatory parameters to predict the discrimination of the phases of Peyronie's disease (PD). Materials and methods Demographic, clinical, and laboratory data from 156 patients with PD were analyzed. A complete blood count (CBC) was obtained for every patient, and the neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and monocyte‐to‐eosinophil ratio (MER) were calculated for every men. Subsequently, patients were divided into two groups based upon the phase of the disease. Results The mean age was 51.9 ± 9.6 in all study population. The mean duration between symptom onset and patient evaluation was 4.2 ± 3.2 months in acute phase group, while it was 32.7 ± 31.7 months in chronic phase group (p < 0.001). There were no significant differences between the groups according to comorbidities such as diabetes, hypertension, lipid abnormalities, ischemic heart disease, smoking, and alcohol consumption. There was a statistically significant difference in NLR and PLR between two groups (p = 0.008, p = 0.008, respectively). NLR and PLR were significantly correlated with discrimination status in univariate analysis (p = 0.003, p = 0.005, respectively). Multivariate regression analysis revealed that NLR was the only independent risk factor for discrimination of the phases of PD (p < 0.001). The ROC analysis revealed a cutoff value of 1.8 (AUC 0.712, p < 0.001; sensitivity 61.1%; specificity 75.0%) for the NLR. Conclusion Our study demonstrated that NLR could be helpful to differentiate the chronic phase from the acute phase in patients with PD. Therefore, NLR could be used as an objective biomarker to the management of the disease and choosing the appropriate treatment.

Should haematological inflammatory markers be included as an adjuvant in the differential diagnosis of acute scrotal pathologies?

“…The predictive value of NLR in solid cancers and the association of its high cut‐off value with decreased overall survival have been shown in the literature several times (Budzianowski et al, 2017; Wang et al, 2017) and what makes our study original is that its differential diagnostic value has been established not only with the healthy control group but also with ASPs which can be frequently confused. While the well‐known prognostic cut‐off value of NLR is >4 mg/L in the literature, its predictive value has shown the difference in similar studies examining the TTm‐control group (Boccellino et al, 2017; Ozbir et al, 2020; Ruiz Montes et al, 1994). While the cut‐off, specificity and sensitivity values in our study were similar to those of Arda et al, we thought that the difference with Yuksel et al (2016) study may be related to the smaller number of cases and the control group.…”

“…Receiver-operating characteristic analysis of NLR, MER, PLR and RDW among the patients groups group but also with ASPs which can be frequently confused. While the well-known prognostic cut-off value of NLR is >4 mg/L in the literature, its predictive value has shown the difference in similar studies examining the TTm-control group (Boccellino et al, 2017;Ozbir et al, 2020;Ruiz Montes et al, 1994). While the cut-off, specificity and sensitivity values in our study were similar to those of Arda et al, we thought that the difference with Yuksel et al…”

“…In addition to the clinical variables for the differential diagnosis of ASPs and research based on DU signs, recent studies have focussed on inflammatory haematological parameters derived from CBC demonstrating an adjuvant role in the differential diagnosis of ASPs (Arikan et al, 2021; Klinke et al, 2020; Konishi et al, 2017; Liu et al, 2021; Ozbir et al, 2020; Patel et al, 2013; Rachidi et al, 2014).…”

Role of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Peyronie's disease

“…Multiple studies in recent years linked the NLR and PLR to a pro-inflammatory stage and with numerous conditions and pathologies. 17 18 19 20 21 There is just one published paper relating these ratios with PD. They analyzed 156 patients with PD and NLR and PLR were calculated.…”

“…There is just one previous paper linking these ratios with PD. 21 They found statistically significant differences in NLR and PLR between acute and chronic groups. The aim of this study is to corroborate these results evaluating the NLR and PLR in PD patients and comparing their values in the acute and chronic stages.…”