The Role of Inflammatory Markers in the Cardioprotective Effect of L-Carnitine in L-NAME-Induced Hypertension

Abstract

The chronic administration of LC reduces blood pressure and attenuates the inflammatory process associated with arterial hypertension. LC might produce a partial inactivation in the RAS resulting in a reduction in the production and effects of angiotensin II.

Efficacy of Osmoprotectants on Prevention and Treatment of Murine Dry Eye

“…This indicates that these compounds were able to at least partially ameliorate the inflammatory responses, consistent with previous reports of the anti-inflammatory properties of L-carnitine and betaine. 40,41 It should be noted that among all the compounds, L-carnitine presented the only statistically significant, and the most beneficial effect, on lowering inflammatory responses of all the mediators investigated and demonstrated in both schedules. L-carnitine is essential in maintaining the health of cells 42 and is best known for its important role in the mitochondrial oxidation of long-chain fatty acids.…”

“…[42][43][44] Reports further indicate that L-carnitine also possesses anti-inflammatory and immunosuppressive activities. 40,41 An in vivo study using a murine model of Crohn's disease revealed that systemic administration/treatment with L-carnitine during the establishment of colonic inflammation successfully reduced cytokine production and intestinal inflammation, and this protection was associated with a suppressive effect of L-carnitine on the colonic mRNA expression and serum of IL-1b and IL-6. 43 In humans, an immunosuppressive role of L-carnitine is also observed with reduction of TNF-a levels in surgical and AIDS patients after receiving L-carnitine supplementation.…”

Non-hemodynamic factors associated to the risk of developing hypertensive cardiopathy

“…Finally, renal and cardiac tubulointerstitial ibrosis takes place and, as a consequence, dysfunction of both organs [60,61]. Concretely, it would be another indicator of universal endothelial functional and structural alteration and of prediction of hypertensive cardiopathy.…”

Hemodiyaliz Hastalarında Karnitin Kullanımı

“…Ancak yapılan karnitin desteği prostaglandin I 2 ve nitrik oksit üretimini tekrar artırabilmekte ve ROS üretimini azaltmaktadır. Dahası proinflamatuvar sitokinlerin plazma ve miyokardial ekspresyonunu azaltarak kardiyovasküler hastalıklara karşı koruyucu bir rol oynamaktadır (16,17).…”