The role of indoleamine 2,3 dioxygenase in the induction of immune tolerance in organ transplantation

Palafox, Damián; Llórente, Luis; Alberú, Josefina; Torres-Machorro, Adriana; Camorlinga, Nancy; Rodríguez, Cinthya; Granados, Julio

doi:10.1016/j.trre.2010.04.003

Cited by 17 publications

(10 citation statements)

References 48 publications

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“…IDO has been shown to reduce immune rejection and induce immune tolerance via degradation of local tryptophan and generation of kynurenine, and mediating T cell apoptosis [23][24][25]. IDO may also facilitate the transformation of naïve T cells into Treg cells and subsequent maintenance of Treg cell activity.…”

Section: Discussionmentioning

confidence: 99%

IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation

et al. 2012

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Section: Discussionmentioning

confidence: 99%

IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation

et al. 2012

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“…Apart from its well-recognized function, it is evident that IDO plays an important role in suppressing the proliferation and differentiation of effector T cells (Frumento et al, 2002), and inducing tolerance by enhancing the suppressor activity of regulatory T cells (Muller et al, 2005;Sharma et al, 2009). The roles of IDO in tolerance induction have been seen in many scenarios, including mammalian pregnancy (Munn, 1998), transplantation (Palafox et al, 2010), chronic infections (Romani et al, 2008), autoimmune disease (Platten et al, 2005), tumor resistance (Munn and Mellor, 2007;Gasparri et al, 2008), and asthma (van der Sluijs et al, 2013). IDO also gives rise to tumor cells that have tolerance against tumorassociated antigens.…”

Section: Indoleamine 2 3-dioxygenase In Oncogenesismentioning

confidence: 99%

A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer

Arumuggam

Bhowmick

Rupasinghe

2015

Phytotherapy Research

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Cancer remains a major health problem worldwide. Among many other factors, two regulatory defects that are present in most cancer cells are constitutive activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway and the induction of indoleamine 2, 3-dioxygenase (IDO), an enzyme that catalyzes tryptophan degradation, through JAK/STAT signaling. Cytokine signaling activates STAT proteins in regulating cell proliferation, differentiation, and survival through modulation of target genes. Many phytochemicals can inhibit both JAK/STAT signaling and IDO expression in antigen-presenting cells by targeting different pathways. Some of the promising phytochemicals that are discussed in this review include resveratrol, cucurbitacin, curcumin, (-)-epigallocatechin gallate, and others. It is now evident that phytochemicals play key roles in inhibition of tumor proliferation and development and provide novel means for therapeutic targeting of cancer.

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“…As a result, IDO1 controls and fine-tunes both innate and adaptive immune responses [6] under a variety of conditions, including pregnancy[7], transplantation[8], infection [9], chronic inflammation [10], autoimmunity [11], neoplasia, and depression[12]. Owing to the outstanding immune-modulate properties of IDO1, IDO1 inhibitors have been searched for in many fields, to control various inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Effects of Various Phytochemicals on Indoleamine 2,3-Dioxygenase 1 Activity: Galanal Is a Novel, Competitive Inhibitor of the Enzyme

Yamamoto

Imai

et al. 2014

PLoS ONE

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Indoleamine 2,3-dioxygenase (IDO) 1, that catalyzes the first and rate-limiting step in the degradation of L-tryptophan, has an important immunomodulatory function. The activity of IDO1 increases in various inflammatory diseases, including tumors, autoimmune diseases, and different kinds of inflammation. We evaluated the suppressive effect of plant extracts or phytochemicals on IDO1 induction and activity; sixteen kinds of plants extracts and fourteen kinds of phytochemicals were examined. As a result, the methanol extracts of Myoga flower buds, which are traditional Japanese foods, and labdane-type diterpene galanal derived from Myoga flowers significantly suppressed IDO1 activity. The Lineweaver-Burk plot analysis indicated that galanal is a competitive inhibitor. Galanal attenuated L-kynurenine formation with an IC50 value of 7.7 µM in the assay system using recombinant human IDO1, and an IC50 value of 45 nM in the cell-based assay. Further, mechanistic analysis revealed that galanal interfered with the transcriptional function of the nuclear factor-κB and the interferon-γ signaling pathway. These effects of galanal are important for immune response. Because the inhibitory effect of galanal on IDO1 activity was stronger than that of 1-methyl tryptophan, a tryptophan analog, galanal may have great potential as the novel drug for various immune-related diseases.

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The role of indoleamine 2,3 dioxygenase in the induction of immune tolerance in organ transplantation

Cited by 17 publications

References 48 publications

IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation

IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation

A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer

Effects of Various Phytochemicals on Indoleamine 2,3-Dioxygenase 1 Activity: Galanal Is a Novel, Competitive Inhibitor of the Enzyme

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