2018
DOI: 10.1590/0102-672020180001e1366
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The Role of Immunoinflammatory Markers in the Prognosis and Resectability of Pancreatic Adenocarcinoma

Abstract: Background: Pancreatic adenocarcinoma has a high mortality rate. A prognostic tool is essential for a better risk stratification. The neutrophil/lymphocyte ratio and adaptations and the platelet/lymphocyte ratio seem promising for this purpose. Aim: Evaluate the prognostic value of neutrophil/lymphocyte ratio, derived neutrophil/lymphocyte ratio and platelet/lymphocyte ratio, analyze the ideal cutoff values and investigate their utility in predicting resectability. Methods: Data were collected of patients wi… Show more

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Cited by 2 publications
(3 citation statements)
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References 28 publications
(58 reference statements)
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“…Eyff et al 23 avaliaram pacientes com adenocarcinoma pancreático, cuja coorte compreendia tanto indivíduos com tumores ressecáveis submetidos a cirurgia, quanto pacientes com turmores irressecáveis, que foram submetidos a tratamento paliativo. Houve diferença estatisticamente significativa na sobrevida global dos pacientes submetidos à quimioterapia paliativa, onde os pacientes com RNL >4,11 e RPL >362 apresentaram um mau prognóstico.…”
Section: Discussionunclassified
“…Eyff et al 23 avaliaram pacientes com adenocarcinoma pancreático, cuja coorte compreendia tanto indivíduos com tumores ressecáveis submetidos a cirurgia, quanto pacientes com turmores irressecáveis, que foram submetidos a tratamento paliativo. Houve diferença estatisticamente significativa na sobrevida global dos pacientes submetidos à quimioterapia paliativa, onde os pacientes com RNL >4,11 e RPL >362 apresentaram um mau prognóstico.…”
Section: Discussionunclassified
“…After the full-text screening, 1 article, which did not collect post-treatment NLR value, 12 4 articles, which did not calculate NLR difference and did not analyze the correlation between NLR change and long-term survival, [13][14][15][16] and 1 article that took odds ratio (OR) to reflect the prognostic value of NLR change on pancreatic adenocarcinoma treatment 17 were excluded. Finally, 6 studies were included in this metaanalysis [18][19][20][21][22][23] (Figure 1). The characteristics of the included studies are summarized in Table 1.…”
Section: Selection and Characteristics Of Included Studiesmentioning
confidence: 99%
“…Moreover, one study investigated the association between post-treatment NLR and OS, as well as the prognostic impact on survival of post-treatment NLR (HR ¼ 1.28, 95% CI ¼ 1.08-1.52). 20 Records idenƟfied through database searching (n = 778)…”
Section: Prognostic Value Of Pre-treatment and Post-treatment Nlrmentioning
confidence: 99%