The Role of Immunity in the Pathogenesis of Experimental Retrograde Pyelonephritis

Hunter, Betty; Akins, Lona L.; Sanford, Jay P.

doi:10.1084/jem.119.6.869

Cited by 19 publications

(6 citation statements)

References 5 publications

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“…Pyelonephritis produced with Escherichia coli or Proteus mirabilis was associated with the development of circulating agglutinins and resistance to both hematogenous and retrograde reinfection with the same organism (43,44). The studies of Arana, Kozij, and Jackson suggested that while resistance to reinfection could be demonstrated in experimental retrograde pyelonephritis, the protection achieved after immunization or previous infection appeared to be independent of the level of serum antibody (45).…”

Section: Local Immune Response In Experimental Pyelonephritismentioning

confidence: 99%

“…Studies in experimental animals have demonstrated that immunity may play a significant role in the pathogenesis of pyelonephritis (41)(42)(43)(44)(45). Pyelonephritis produced with Escherichia coli or Proteus mirabilis was associated with the development of circulating agglutinins and resistance to both hematogenous and retrograde reinfection with the same organism (43,44).…”

Section: Local Immune Response In Experimental Pyelonephritismentioning

confidence: 99%

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Local immune response in experimental pyelonephritis

Lehmann¹,

Smith²,

Miller³

et al. 1968

J. Clin. Invest.

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Section: Local Immune Response In Experimental Pyelonephritismentioning

confidence: 99%

Section: Local Immune Response In Experimental Pyelonephritismentioning

confidence: 99%

Local immune response in experimental pyelonephritis

Lehmann¹,

Smith²,

Miller³

et al. 1968

J. Clin. Invest.

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“…The result suggests that the humoral antibody produced by subcutaneous immunization has no effect on ascending infection with E. coli. It is of interest, however, that Hunter et al (12) found that the kidney was protected from pyelonephritis with ascending Proteus mirabilis infection in the rat by prior infection or immunization. Domingue et al (7) were also able to prevent retrograde pyelonephritis with P. mirabilis by immunizing rabbits with common antigen derived from Salntonella typhimurium.…”

Section: Discussionmentioning

confidence: 99%

Pyelonephritis XIV. Effect of Immunization on Experimental Escherichia coli Pyelonephritis

et al. 1972

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Mice immunized subcutaneously with heat-killed Escherichia coli were protected from pyelonephritis produced by the intravenous route, but there was little or no protection from ascending infection. No significant protection from ascending or hematogenous pyelonephritis was demonstrated when immunization was accomplished by injecting heat-killed E. coli into the bladder. Heat-killed E. coli injected either subcutaneously or into the bladder protected mice from early endotoxic death after intravenous or bladder challenge.

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“…Vaccines against P. mirabilis infection have been tested since at least the 1960s, when heat-killed P. mirabilis protected rats from pyelonephritis by promoting renal clearance of bacteria (327). A preparation of P. mirabilis outer membrane protein promoted renal clearance in mice and protected mice from renal infection and death (326).…”

Section: Uti Vaccinesmentioning

confidence: 99%

Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections

O’Brien¹,

Hannan

Nielsen³

et al. 2016

Microbiol Spectr

111

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Urinary tract infections (UTI) are among the most common bacterial infections in humans, affecting millions of people every year. UTI cause significant morbidity in women throughout their lifespan, in infant boys, in older men, in individuals with underlying urinary tract abnormalities, and in those that require long-term urethral catheterization, such as patients with spinal cord injuries or incapacitated individuals living in nursing homes. Serious sequelae include frequent recurrences, pyelonephritis with sepsis, renal damage in young children, pre-term birth, and complications of frequent antimicrobial use including high-level antibiotic resistance and Clostridium difficile colitis. Uropathogenic E. coli (UPEC) cause the vast majority of UTI, but less common pathogens such as Enterococcus faecalis and other enterococci frequently take advantage of an abnormal or catheterized urinary tract to cause opportunistic infections. While antibiotic therapy has historically been very successful in controlling UTI, the high rate of recurrence remains a major problem, and many individuals suffer from chronically recurring UTI, requiring long-term prophylactic antibiotic regimens to prevent recurrent UTI. Furthermore, the global emergence of multi-drug resistant UPEC in the past ten years spotlights the need for alternative therapeutic and preventative strategies to combat UTI, including anti-infective drug therapies and vaccines. In this chapter, we review recent advances in the field of UTI pathogenesis, with an emphasis on the identification of promising drug and vaccine targets. We then discuss the development of new UTI drugs and vaccines, highlighting the challenges these approaches face and the need for a greater understanding of urinary tract mucosal immunity.

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The Role of Immunity in the Pathogenesis of Experimental Retrograde Pyelonephritis

Cited by 19 publications

References 5 publications

Local immune response in experimental pyelonephritis

Local immune response in experimental pyelonephritis

Pyelonephritis XIV. Effect of Immunization on Experimental Escherichia coli Pyelonephritis

Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections

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