2016
DOI: 10.1007/s00436-016-5066-6
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The role of IL-33/ST2, IL-4, and eosinophils on the airway hyperresponsiveness induced by Strongyloides venezuelensis in BALB/c mice

Abstract: Strongyloidiasis is a neglected chronic nematode infection, in which the control of autoinfection rate and severity of disease is dependent on type 2 immune responses. Strongyloides also causes Th2 responses in the lung of infected animals and changes in airway function, including airway hyperresponsiveness (AHR). Mechanisms of AHR during Strongyloides venezuelensis infection are not entirely known, and we investigate here the role of IL-4, eosinophils, and IL-33/ST2. AHR was evaluated in infected mice by dete… Show more

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Cited by 7 publications
(4 citation statements)
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“…The activation of the IL-33/ST2 pathway has been previously studied in nematode infection. In infection with Strongyloides venezuelensis it is responsible for inducing pulmonary eosinophilic inflammation, maintaining airway hyperresponsiveness, Th2 response in the lungs and consequently may play a role in expelling the worms from the lungs[ 18 , 19 ]. Resende et al .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The activation of the IL-33/ST2 pathway has been previously studied in nematode infection. In infection with Strongyloides venezuelensis it is responsible for inducing pulmonary eosinophilic inflammation, maintaining airway hyperresponsiveness, Th2 response in the lungs and consequently may play a role in expelling the worms from the lungs[ 18 , 19 ]. Resende et al .…”
Section: Introductionmentioning
confidence: 99%
“…The activation of the IL-33/ST2 pathway has been previously studied in nematode infection. In infection with Strongyloides venezuelensis it is responsible for inducing pulmonary eosinophilic inflammation, maintaining airway hyperresponsiveness, Th2 response in the lungs and consequently may play a role in expelling the worms from the lungs [18,19]. Resende et al [6] observed high concentrations of IL-33 in BALB/c mice infected with T. canis from the 5th day after infection, however, the importance of activating the IL-33/ST2 pathway to control parasitic burden and pathophysiology in the context of T. canis infection has not yet been demonstrated.…”
Section: Introductionmentioning
confidence: 99%
“…Strongyloidiasis can be asymptomatic [ 30 ], but in some cases can elicit allergic respiratory or cutaneous manifestations. Murine models show that this parasite induces airway hyperreactivity with asthma-like characteristics, such as eosinophilic inflammation, mucus hypersecretion, and bronchial wall thickening [ 31 ]. In humans, the infection can manifest with chronic cough, mimic asthma exacerbations, or worsen stable asthma, thus complicating the evolution and management of this disease [ 32 , 33 •, 34 ].…”
Section: Helminth Allergensmentioning
confidence: 99%
“…Nas formas moderada e grave podem ser reportados sinais e sintomas cutâneos, pulmonares, gastrointestinais, havendo predomínio de manifestações digestivas como mencionado acima. As manifestações são mais intensas nos casos de disseminação, aumento na secreção de muco, tendo como objetivo a eliminação do parasito(ARAUJO et al, 2016;BRELOER, ABRAHAM, 2016;NUTMAN, 2016;). Os hospedeiros infectados com Strongyloides sp.…”
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