The Role of IL-33 in Experimental Heart Transplantation

Chen, Jie; Xie, Zhongming; Wei, Yingying; Duan, Lihua

doi:10.1155/2020/6108362

Cited by 3 publications

(3 citation statements)

References 99 publications

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“…Among patients receiving kidney transplantation, serum levels of IL-33 were higher in chronic allograft dysfunction patients compared to patients with stable graft function [ 257 ]. The research on cardiac IR and IR-induced myocardial injury found that IL-33 may have beneficial effects by suppressing inflammatory cytokines’ expression and myocardial apoptosis, and increasing production of Th2 type cytokines and an upset in the balance of Th1/Th2 responses during heart transplantation [ 263 , 264 ]. Donor mouse cardiac allografts deficient in IL-33 exhibited dramatically accelerated vascular occlusion and subsequent fibrosis, which was accompanied by local proinflammatory iNOS + macrophage augmentation [ 265 ].…”

Section: Il-33 and Immune-related Diseasesmentioning

confidence: 99%

Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions

Guo

Bossila

et al. 2022

Cells

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Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine, plays critical roles in maintaining host homeostasis and in pathological conditions, such as allergy, infectious diseases, and cancer, by acting on multiple types of immune cells and promoting type 1 and 2 immune responses. IL-33 is rapidly released by immune and non-immune cells upon stimulation by stress, acting as an “alarmin” by binding to its receptor, suppression of tumorigenicity 2 (ST2), to trigger downstream signaling pathways and activate inflammatory and immune responses. It has been recognized that IL-33 displays dual-functioning immune regulatory effects in many diseases and has both pro- and anti-tumorigenic effects, likely depending on its primary target cells, IL-33/sST2 expression levels, cellular context, and the cytokine microenvironment. Herein, we summarize our current understanding of the biological functions of IL-33 and its roles in the pathogenesis of various conditions, including inflammatory and autoimmune diseases, infections, cancers, and cases of organ transplantation. We emphasize the nature of context-dependent dual immune regulatory functions of IL-33 in many cells and diseases and review systemic studies to understand the distinct roles of IL-33 in different cells, which is essential to the development of more effective diagnoses and therapeutic approaches for IL-33-related diseases.

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Section: Il-33 and Immune-related Diseasesmentioning

confidence: 99%

Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions

Guo

Bossila

et al. 2022

Cells

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“…However, there are significant differences between levels of mast cells in mice and humans, which may reduce the translatability of these findings. Even so, IL-33 is thought to have a protective role in reducing heart allograft and xenograft rejection [38]. This protective role was demonstrated with reduced immune response-related damages and suggested that IL-33 could be developed as a therapeutic approach to transplant rejection [38].…”

Section: Effects Of Il-33 On the Cardiovascular And Pulmonary Systemsmentioning

confidence: 99%

“…Even so, IL-33 is thought to have a protective role in reducing heart allograft and xenograft rejection [38]. This protective role was demonstrated with reduced immune response-related damages and suggested that IL-33 could be developed as a therapeutic approach to transplant rejection [38].…”

Section: Effects Of Il-33 On the Cardiovascular And Pulmonary Systemsmentioning

confidence: 99%

The Role of Pro-Inflammatory and Regulatory Signaling by IL-33 in the Brain and Liver: A Focused Systematic Review of Mouse and Human Data and Risk of Bias Assessment of the Literature

Zharichenko

Njoku

2020

IJMS

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Interleukin (IL)-33 is a member of the IL-1 family of proteins that have multiple roles in organ-specific inflammation. Many studies suggest diagnostic and therapeutic implications of this cytokine. Many studies have reported pro-inflammatory roles for IL-33 in innate immune responses involving the heart and lung. Recent studies also describe pro-inflammatory and regulatory roles for IL-33 in the pathogenesis of brain and liver disorders in addition to regulatory roles for this cytokine in the heart and lung. In this focused systematic review, we will review the literature regarding pro-inflammatory and regulatory effects of IL-33 in the brain and liver. We will also assess the potential risk of bias in the published literature in order to uncover gaps in the knowledge that will be useful for the scientific community. We utilized guidelines set by preferred reporting items for systemic reviews and meta-analyses. The electronic database was PubMed. Eligibility criteria included organ-specific inflammation in mice and humans, organ-specific inflammation in the central nervous and hepatic systems, and IL-33. Outcomes were pro-inflammatory or regulatory effects of IL-33. Risk of bias in individual studies and across studies was addressed by adapting the Cochrane Rob 2.0 tool. We discovered that a source of bias across the studies was a lack of randomization in human studies. Additionally, because the majority of studies were performed in mice, this could be perceived as a potential risk of bias. Regarding the central nervous system, roles for IL-33 in the development and maturation of neuronal circuits were reported; however, exact mechanisms by which this occurred were not elucidated. IL-33 was produced by astrocytes and endothelial cells while IL-33 receptors were expressed by microglia and astrocytes, demonstrating that these cells are first responders for IL-33; however, in the CNS, IL-33 seems to induce Th1 cytokines such as IL-1β and TNF-α chemokines such as RANTES, MCP-1, MIP-1α, and IP-10, as well as nitric oxide. In the liver, similar risks of bias were determined because of the lack of randomized controlled trials in humans and because the majority of studies were performed in mice. Interestingly, the strain of mouse utilized in the study seemed to affect the role of IL-33 in liver inflammation. Lastly, similar to the brain, IL-33 appeared to have ST2-independent regulatory functions in the liver. Our results reveal plausible gaps in what is known regarding IL-33 in the pathogenesis of brain and liver disorders. We highlight key studies in the lung and heart as examples of advancements that likely occurred because of countless basic and translational studies in this area. More research is needed in these areas in order to assess the diagnostic or therapeutic potential of IL-33 in these disorders.

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Multifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair

Gao

You

et al. 2023

Acta Biomaterialia

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The Role of IL-33 in Experimental Heart Transplantation

Cited by 3 publications

References 99 publications

Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions

Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions

The Role of Pro-Inflammatory and Regulatory Signaling by IL-33 in the Brain and Liver: A Focused Systematic Review of Mouse and Human Data and Risk of Bias Assessment of the Literature

Multifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair

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