The role of IL-2, and IL-27, in combination with retinoic acid in the B cells, APC, CD4+ T cell subsets (Th1, Th17 and Treg), and CD8+ T cells response in EAE modele

Bitsue, Zelalem Kiros

doi:10.14299/ijser.2017.05.015

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“…Cytokines play a key role in the regulation of the immune response (Bitsue et al, 2017). JAK2-STAT3 pathway is one of the important inflammatory signaling pathways in the immune system, Classical studies suggest that this pathway promotes the secretion of TNF-α and IL-6, resulting in an inflammatory response (Sugaya, 2008), and JAK2/STATs signaling being a common pathway used by many cytokines to regulate target genes relating to cell survival and immune responses in pathological process (Hoyt et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Effects of JAK2 / STAT3 Signaling Pathway Activation on Intracellular Survival of Brucella

Yi¹

2018

PVJ

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Brucellosis is an important zoonotic pathogen of worldwide distribution that causes disease in both humans and animals. Brucella can weaken the immune ability of host cells and its pathogenesis depends on its ability to replicate intracellularly and inhibit host cell apoptosis. The JAK2/STAT3 pathway is known to regulate various biological functions, to include cell differentiation, cell death, and apoptosis. However, the role of this pathway in the survival of virulent or low virulent Brucella strains in macrophages remains largely uncharacterized. In this study, the JAK2/STAT3 pathway was found to be activated by both smooth Brucella abortus 2308 (B. abortus; virulent) and rough B. abortus RB51 (low virulent), but only B. abortus RB51 significantly induced JAK2 and STAT3 phosphorylation in a timedependent manner. Furthermore, in B. abortus RB51, JAK2/STAT3 phosphorylation was inhibited by AG490 (inhibitor of JAK2/STAT3 pathway) in a dosedependent manner and B. abortus RB51-mediated apoptosis and cytokines (IL-6, TNF-α) expression were also inhibited. These findings suggest that JAK2/ STAT3 pathway is important to intercellular survival during a B. abortus RB51 infection, but does not appear to play an apparent role in B. abortus 2308 survival. , 2018. Effects of JAK2 / STAT3 Signaling Pathway Activation on Intracellular Survival of Brucella. Pak Vet J, 38(2): 153-158. http://dx.

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Section: Discussionmentioning

confidence: 99%

Effects of JAK2 / STAT3 Signaling Pathway Activation on Intracellular Survival of Brucella

Yi¹

2018

PVJ

View full text Add to dashboard Cite

show abstract

The role of IL-2, and IL-27, in combination with retinoic acid in the B cells, APC, CD4+ T cell subsets (Th1, Th17 and Treg), and CD8+ T cells response in EAE modele

Cited by 1 publication

References 0 publications

Effects of JAK2 / STAT3 Signaling Pathway Activation on Intracellular Survival of Brucella

Effects of JAK2 / STAT3 Signaling Pathway Activation on Intracellular Survival of Brucella

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