The role of IL-10-producing B cells in repeated implantation failure patients with cellular immune abnormalities

Koushaeian, Ladan; Ghorbani, Farzaneh; Ahmadi, Majid; Eghbal‐Fard, Shadi; Zamani, Majid; Danaii, Shahla; Yousefi, Bahman; Jadidi‐Niaragh, Farhad; Hamdi, Kobra; Yousefi, Mehdi

doi:10.1016/j.imlet.2019.08.002

Cited by 15 publications

(12 citation statements)

References 21 publications

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“…Very recent reports pointed out the relevance of IL-10 in human pregnancy. Although increased production of this cytokine is associated with successful embryo implantation [40], low IL-10 expression has been related to a decrease in endometrial receptivity resulting in blastocyst implantation failures [41].…”

Section: Discussionmentioning

confidence: 99%

Blastocyst-Bearing Sows Display a Dominant Anti-Inflammatory Cytokine Profile Compared to Cyclic Sows at Day 6 of the Cycle

Parrilla

Martínez

Cambra

et al. 2020

Animals

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In the context of porcine embryo transfer (ET) technology, understanding the tightly regulated local uterine immune environment is crucial to achieve an adequate interaction between the transferred embryos and the receiving endometrium. However, information is limited on the uterine immune status of cyclic-recipient sows when receiving embryos during ET. The present study postulated that the anti- and proinflammatory cytokine profile 6 days after the onset of estrus differs between endometria from uninseminated cyclic sows and blastocyst-bearing sows. On Day 6 of the cycle, endometrial explants were collected from sows inseminated or not inseminated during the postweaning estrus and cultured for 22 h. The culture medium was then analyzed for the contents of a total of 16 cytokines using Luminex MAP® technology. The results showed important differences in the endometrial production of most cytokines between the sow categories, with a predominant anti-inflammatory environment displayed by the blastocyst-bearing endometria. These findings suggest that sperm, seminal plasma (SP) and/or early embryos modify the uterine environment by inducing an immune-tolerant cytokine profile already visible at Day 6. Whether the SP or some of its active components may help to develop strategies to maximize the reproductive performance of recipients after ET needs further investigation.

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Section: Discussionmentioning

confidence: 99%

Blastocyst-Bearing Sows Display a Dominant Anti-Inflammatory Cytokine Profile Compared to Cyclic Sows at Day 6 of the Cycle

Parrilla

Martínez

Cambra

et al. 2020

Animals

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“…In addition, CD19+CD24(high+)CD27+ regulatory B-cells were demonstrated to produce IL-10 by hCG stimulation via LH/hCG receptors [129]. This type of regulatory B-cell was proposed to mediate the positive effects of hCG on the immune environment during pregnancy [130,131].…”

Section: Regulation Of Endometrial Receptivity and Embryo Invasion Bymentioning

confidence: 99%

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

Fujiwara

Ono

Sato

et al. 2020

IJMS

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Embryo implantation in the uterus is an essential process for successful pregnancy in mammals. In general, the endocrine system induces sufficient embryo receptivity in the endometrium, where adhesion-promoting molecules increase and adhesion-inhibitory molecules decrease. Although the precise mechanisms remain unknown, it is widely accepted that maternal–embryo communications, including embryonic signals, improve the receptive ability of the sex steroid hormone-primed endometrium. The embryo may utilize repulsive forces produced by an Eph–ephrin system for its timely attachment to and subsequent invasion through the endometrial epithelial layer. Importantly, the embryonic signals are considered to act on maternal immune cells to induce immune tolerance. They also elicit local inflammation that promotes endometrial differentiation and maternal tissue remodeling during embryo implantation and placentation. Additional clarification of the immune control mechanisms by embryonic signals, such as human chorionic gonadotropin, pre-implantation factor, zona pellucida degradation products, and laeverin, will aid in the further development of immunotherapy to minimize implantation failure in the future.

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“…These alterations commonly originate from the abnormal functioning of Treg and Breg cells, which in RIF cases tend to overproduce pro-inflammatory cytokines inducing immune embryotoxic phenomena finally resulting in RIF or/and recurrent miscarriages. This cytotoxic function of regulatory immune cells has been reported in both peripheral blood and endometrial tissue samples obtained from RIF patients [122,[124][125][126][127]. For example, in the study published by Fukui et al, 2008, the numbers of TNF-a-producing CD56 bright NK cells was significantly increased in women with RIF compared with fertile controls [126].…”

Section: Abnormally Increased Levels Of Pro-inflammatory Cytokines Or...mentioning

confidence: 60%

“…Taking into account that alterations in IL-12/Il-15/IL-18 and TWEAK expression patterns are associated with increased uNK cytotoxicity, one could extrapolate that similar alterations regarding other cytokines, such as IL-10, TNF-a, IL-4, IL-5, IL-10, IL-13, and GM-CSF could lead to abnormally increased numbers of cytotoxic T cell and B cell subtypes [122,[124][125][126][127]. These alterations commonly originate from the abnormal functioning of Treg and Breg cells, which in RIF cases tend to overproduce pro-inflammatory cytokines inducing immune embryotoxic phenomena finally resulting in RIF or/and recurrent miscarriages.…”

Section: Abnormally Increased Levels Of Pro-inflammatory Cytokines Or...mentioning

confidence: 99%

The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature

Pantos¹,

Grigoriadis

Maziotis

et al. 2022

IJMS

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Recurrent implantation failure (RIF) is a multifactorial condition affecting 10–15% of in vitro fertilization (IVF) couples. Data suggest that functional dysregulation of the endometrial immune system constitutes one of the main pathophysiological mechanisms leading to RIF. The aim of this article is to provide a thorough presentation and evaluation of the role of interleukins (ILs) in the pathogenesis of RIF. A comprehensive literature screening was performed summarizing current evidence. During implantation, several classes of ILs are secreted by epithelial and stromal endometrial cells, including IL-6, IL-10, IL-12, IL-15, IL-18, and the leukemia inhibitory factor. These ILs create a perplexing network that orchestrates both proliferation and maturation of uterine natural killer cells, controls the function of regulatory T and B cells inhibiting the secretion of antifetal antibodies, and supports trophoblast invasion and decidua formation. The existing data indicate associations between ILs and RIF. The extensive analysis performed herein concludes that the dysregulation of the ILs network indeed jeopardizes implantation leading to RIF. This review further proposes a mapping of future research on how to move forward from mere associations to robust molecular data that will allow an accurate profiling of ILs in turn enabling evidence-based consultancy and decision making when addressing RIF patients.

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The role of IL-10-producing B cells in repeated implantation failure patients with cellular immune abnormalities

Cited by 15 publications

References 21 publications

Blastocyst-Bearing Sows Display a Dominant Anti-Inflammatory Cytokine Profile Compared to Cyclic Sows at Day 6 of the Cycle

Blastocyst-Bearing Sows Display a Dominant Anti-Inflammatory Cytokine Profile Compared to Cyclic Sows at Day 6 of the Cycle

Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems

The Role of Interleukins in Recurrent Implantation Failure: A Comprehensive Review of the Literature

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