The role of <i>Toxoplasma gondii</i> as a possible inflammatory agent in the pathogenesis of type 2 diabetes mellitus in humans

Molan, Aus; Nosaka, Kazunori; Hunter, Michael; Wang, Weiwei

doi:10.15212/fmch.2016.0128

Cited by 13 publications

(11 citation statements)

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“…T. gondii creates a dominant Thelper type 1 (Th1) cell-mediated inflammatory response. 9 The ability of the host to control T. gondii depends on the subsequent production of interleukin (IL)-12 by macrophages and dendritic cells by Toll-like receptors. Also, IL-12 stimulates natural killer cells and CD4+and CD8+T cells to release interferon gamma (IFN-γ).…”

Section: Introductionmentioning

confidence: 99%

“…IL-10, TGF-β, and IL-27 are vital down-regulators that prevent the overproduction of Th1-type cytokines, thereby regulating inflammation. 9 Strong Th1 immune response leads to tachyzoites which turn into bradyzoites and leads to prolonged immunity. The infected host is asymptomatic at this time.…”

Section: Introductionmentioning

confidence: 99%

“…The infected host is asymptomatic at this time. 9 Diabetes, which is currently widespread, is a chronic disease which develops with hyperglycemia and forms as a result of deficiencies in insulin hormone or an insufficient effect. There are two types of diabetes; insulin dependent (Type I) and non-insulin dependent (Type II).…”

Section: Introductionmentioning

confidence: 99%

“…In T2DM patients, CD8 and CD16 values, which are markers for NK cells and suppressor T-cells in cellular immunity, in particular, are known to be lower than those of healthy individuals. 9 In this study, the presence of T. gondii antibody was investigated in blood samples from 200 T2DM patients and 100 healthy control subjects in order to investigate the relationship between diabetes and T. gondii.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Toxoplasma gondii infection among diabetic patients in Turkey

Özçelık

Alim

Ozpinar

2020

Clinical Epidemiology and Global Health

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A B S T R A C TBackgound: In some recent studies, it has been suggested that there may be a relationship between Toxoplasma gondii (T. gondii) and type 2 diabetes mellitus (T2DM). T. gondii is of greater significance in these patients.Objectives: In the present study, it was aimed to investigate the seroprevalence of T. gondii in T2DM patients. Methods: To define Toxoplasma IgG and IgM seropositivity and determine the seroprevalence of toxoplasmosis in patients presenting at the Internal Diseases outpatient clinic of the Healthcare Application and Research Hospital, where the ELISA method was used. 200 T2DM patients and 100 healthy individuals with no complaints took part in the study. Results: Toxoplasma IgG positivity was determined in 53% of the 200 T2DM patients and Toxoplasma IgM positivity in 13%. While in the control group, Toxoplasma IgG positivity was determined in 27% and Toxoplasma IgM positivity in 1%. The risk of toxoplasmosis infection in T2DM patients was two folds higher than healthy controls according to the IgG results. IgM results were further differentiated. Conclusions: We believe that the seroprevalence of T. gondii is high in the T2DM patient group and that the causes should be investigated in more detail.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Detection of Toxoplasma gondii infection among diabetic patients in Turkey

Özçelık

Alim

Ozpinar

2020

Clinical Epidemiology and Global Health

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“…Diabet es is an important f act or that increases s usc eptibility and risk of v arious infec tions in t he host ( Molan et al, 2016). O n the ot her hand, it may be caus ed b y Toxoplasma gondii .…”

Section: Introductionmentioning

confidence: 99%

Determination of Antibodies (IgG, IgM) against Toxoplasma gondii in diabetic patients in Baghdad

Hamad¹

2017

Egypt. J. Exp. Biol. (Zoo.)

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ABSTRACT:The curr ent st ud y w as c onduct ed t o d etect the seroprev alenc e lev el immunoglobulin ( IgG , Ig M) of T oxopl asma gondii i nf ection am ong 180 diabet es Patients. 148 c as es w ere f emal e and 32 c as es wer e m ale who at tended National c ent er for R es earc h on diabetes at Al-Yarm ouk hospital i n Baghd ad (age -range 13 -90) years. S erum s amples were t es ted for s ugar b y an enz ym atic m et hod. T he antiToxoplasma specific Ig G, IgM w ere as ses sed using E nz yme Link ed Imm unos orbent Ass ay (ELISA) kits . The res ults r ecorded 112 (62. 2%) and 52(28. 9%) anti -Toxoplasm a Ig G and Ig M s eropositiv e antibodies, w hile i n seroneg ative antib odies Ig G and IgM w ere 68 (37. 8%) and 128(71. 1%), resp ectiv ely. Statisticall y signific ant (P < 0. 05) was f ound between ag e, gender and ser opositiv e Toxoplasma gondii , t he higher p ercent age was recorded in wom en.

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