The Role of<i>Sauropus androgynus</i>(L.) Merr. Leaf Powder in the Broiler Chickens Fed a Diet Naturally Contaminated with Aflatoxin

Prakoso, Yos Adi; Puspitasari,; Rini, Chylen Setiyo; Aliviameita, Andika; Salasia, Siti Isrina Oktavia; Kurniasih,; Ikram, Ahmad Fadhli Dzil; Walalangi, Baristha; Utama, Kukuh Priya; Huda, Muhammad Fajar Al; Su’udiyah, Neneng Ayu

doi:10.1155/2018/2069073

Cited by 8 publications

(5 citation statements)

References 47 publications

(45 reference statements)

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“…The total aflatoxin of chicken feed was routinely tested by Enzyme-Linked Immunosorbent Assays (ELISA). The chicken feed was incubated based on the following method that was indicated by the previous study (Prakoso et al, 2018). The total aflatoxin was measured each day during the study with a triple of replication.…”

Section: Dietmentioning

confidence: 99%

Recent Update: Effects of Aflatoxin in Broiler Chickens

Kurniasih¹,

Prakoso²

2019

jwpr

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Aflatoxin is a worldwide problem in poultry industries as it is known to contaminate poultry feed. Aflatoxin induces stress and increases mortality rate during infection in poultry, especially broiler chickens. The objectives of this study was to observe the pathological effects due to aflatoxicosis in broiler chickens. A total of 120 chickens were divided into four groups, group A fed with a basal diet without aflatoxin contamination, group B with aflatoxin (> 1 ppb < 50 ppb), group C with aflatoxin (> 51 ppb < 100 ppb), group D with aflatoxin (> 101 ppb < 150 ppb). The data were collected and analysed on day 7, 14, and 21. The results showed that diet with high aflatoxin contamination in group D impaired the physical and laboratory performances of the chickens, increased the risk of residue in the poultry's final products. The varying doses of aflatoxin contamination in the chicken feed causes the problems on the broiler chickens with different level of severity.

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Section: Dietmentioning

confidence: 99%

Recent Update: Effects of Aflatoxin in Broiler Chickens

Kurniasih¹,

Prakoso²

2019

jwpr

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“…S. androgynus has similar antioxidant compounds, and it is commonly used as an antioxidant and antitoxic and to prevent ROS production [15]. The utilization of S. androgynus as the feed additive in a broiler increases the immune expression of CD4+/CD8+ lymphocytes that help depress cellular destruction during aflatoxicosis [16]. Similar to the others, A. graveolens is used as an antifungal agent [17], an anti-carcinogenic agent for the treatment of lymphoblastic leukemia, and a radical scavenging agent [18].…”

Section: Introductionmentioning

confidence: 99%

Treatment of experimentally induced diabetic wound infected with methicillin-resistant Staphylococcus aureus using Aloe vera, Apium graveolens, and Sauropus androgynus extracts in rats

et al. 2019

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Background and Aim: One of the complications of diabetes mellitus is diabetic ulcer. Diabetic ulcer is commonly infected by infectious agents, especially methicillin-resistant Staphylococcus aureus (MRSA). This study aimed to evaluate the potential effects of alcoholic extracts of Aloe vera, Apium graveolens, and Sauropus androgynus on promoting wound healing in a diabetic wound infected with MRSA. Materials and Methods: A total of 60 male Sprague-Dawley rats (6 months old, weighing 250-300 g) were injected with 65 mg/kg body weight of streptozotocin to induce diabetes. On day 7, the backs of the rats were shaved, and two circular wounds (4 mm in diameter) were created on their back, which were infected with MRSA. The rats were divided into six groups: Group I = control, Group II = treated with cream base without extract, Group III = treated with 2% A. vera cream, Group IV = treated with 2% A. graveolens cream, Group V = treated with 2% S. androgynus cream, and Group VI = treated with 2% A. vera + 2% A. graveolens + 2% S. androgynus cream. The wounds were treated twice a day for 14 days. The data were collected on days 7 and 14. Results: The results showed that all three herbal extracts and their combination decreased wound area and percentage of the wound, increased tensile strength of skin, collagen deposition, vascular endothelial growth factor expression, and skin thickness, and depressed the C-reactive protein profile and cyclooxygenase-2 expression. Conclusion: A. vera, A. graveolens, and S. androgynus creams can be used as herbal therapies against diabetic wounds infected with MRSA, both as a single and combination treatment.

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“…The role of SA also exhibited the protective effect on the liver, kidney and spleen histopathology during AF exposure by decreasing of the severe liver necrosis and degeneration, and also prevent the necrotic cell and inflammation of tubules epithelial kidney [ 36 ]. Methanolic extract of S. androgynus exhibited antibacterial activity against Salmonella typhimurium and Klebsiella pneumonia [ 37 ]. Apigenin and luteolin contained in SA inhibit the effect of lipopolysaccharide proteins from Gram-negative bacteria [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Hormone-balancing and protective effect of combined extract of Sauropus androgynus and Elephantopus scaber against Escherichia coli-induced renal and hepatic necrosis in pregnant mice

Christina

Diana

Fuzianingsih

et al. 2021

Journal of Ayurveda and Integrative Medicine

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Background Elephantopus scaber (ES) and Sauropus androgynous (SA) have been frequently reported to possess antibacterial activity through in vitro, but in vivo studies about the protective effect of combined ES and SA have acquired less attention. Objectives To evaluate protective effect of combined ethanol extract of ES and SA on hormone imbalance and renal and hepatic necrosis formation in Escherichia coli -infected pregnant mice. Materials and methods A total of 28 pregnant Balb/c mice were divided into seven groups (n = 4): control, E. coli -infected pregnant mice, infected pregnant mice received 200 mg/kg ES, infected pregnant mice received combined 150 mg/kg ES and 37.5 mg/kg SA (75:25), 100 mg/kg ES and 75 mg/kg SA (50:50) , 50 mg/kg ES and 112.5 mg/kg SA (25:75), and only 150 mg/kg SA. Pregnant mice were orally treated with combined ES and SA on day 1–4th of pregnancy. On the 4th day, mice were infected with 10 7 CFU/mL of E. coli and continuously treated with ES and SA until the 16th day of pregnancy. After treatment, the kidney and liver were prepared for histological examination using H&E staining. The blood serum was collected in each stage of pregnancy and measured by ELISA assays. Results Combined ES and SA gave an impact on altering the prolactin level. Combined ES and SA at ratio dose 75:25 was able to restore progesterone to normal levels (P < 0.05). The level of estradiol (E2) was relatively stable in the presence of E. coli and treatment. Treatment with 200 mg/kg ES, combined 50 mg/kg ES and 112.5 mg/kg SA (25:75) and 100 mg/kg ES and 75 mg/kg SA (50:50) demonstrated an immunomodulatory effect on the Gr1 + cell of E. coli treated-pregnant mice. E. coli infection significantly increased renal tubules and hepatic necrosis in pregnant mice compared to control (P < 0.05). Combined SA and ES at ratio dose 75:25 significantly demonstrated remarkable renal and hepatic protection activity in infected pregnant mice. Conclusion The present study provided the establishment of combined ES and SA could be used to invent potent hormonal balancing agent and hepato-renal protective agent in infected pregnant mice.

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The Role ofSauropus androgynus(L.) Merr. Leaf Powder in the Broiler Chickens Fed a Diet Naturally Contaminated with Aflatoxin

Cited by 8 publications

References 47 publications

Recent Update: Effects of Aflatoxin in Broiler Chickens

Recent Update: Effects of Aflatoxin in Broiler Chickens

Treatment of experimentally induced diabetic wound infected with methicillin-resistant Staphylococcus aureus using Aloe vera, Apium graveolens, and Sauropus androgynus extracts in rats

Hormone-balancing and protective effect of combined extract of Sauropus androgynus and Elephantopus scaber against Escherichia coli-induced renal and hepatic necrosis in pregnant mice

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