The Role of Hypoxia on the Trimethylation of H3K27 in Podocytes
Johanna Barth,
Ivonne Loeffler,
Tzvetanka Bondeva
et al.
Abstract:Epigenetic alterations contribute to the pathogenesis of chronic diseases such as diabetes mellitus. Previous studies of our group showed that diabetic conditions reduce the trimethylation of H3K27 in podocytes in a NIPP1- (nuclear inhibitor of protein phosphatase 1) and EZH2- (enhancer of zeste homolog 2) dependent manner. It has been previously reported that in differentiated podocytes, hypoxia decreases the expression of slit diaphragm proteins and promotes foot process effacement, thereby contributing to t… Show more
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