The role of hypoxia-inducible factor 1α in hepatic lipid metabolism

Luo, Mingxiao; Li, Tingting; Sang, Haiquan

doi:10.1007/s00109-023-02308-5

Cited by 6 publications

(4 citation statements)

References 119 publications

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“…In addition, we noticed differences between two groups of cows in oxidative stress, glucose metabolism and lipid metabolism. We speculate that the differences observed in antioxidant capacity (MDA and GSH-Px) (Li et al 2017), NOS metabolism (iNOS and eNOS) (Jeffrey Man et al 2014) and energy metabolism (glucose and TG) (Kierans and Taylor 2021;Luo et al 2023) may attributed to variation in apoptosis profiles between mammary of cows with different lactation persistency.…”

Section: Discussionmentioning

confidence: 86%

Potential role of hypoxia in maintaining lactation persistency of dairy cows

Hu,

Luo,

et al. 2024

Anim. nutriomics

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Mammary gland health plays a key role in maintaining lactation persistency. As a well-known factor involved in physiological processes, the role of oxygen levels in bovine mammary health and lactation persistency remains to be investigated. The present study aimed at investigating the potential regulatory role of hypoxia in the mammary gland of dairy cows with different lactation persistency. Sixty-one Holstein dairy cows were selected for a 180-day experiment at approximately 88 days in milk (DIM). Plasma, milk and mammary tissue samples from 61 cattle were collected on experimental days 0, 90 and 180 (corresponding to 88, 178 and 268 DIM), respectively. Of the 61 cows, 12 cows with high lactation persistency (HP) and 12 with low lactation persistency (LP) were selected for the current study. No difference was observed in milk yield between two groups on d 0 (Pd 0 = 0.67), whereas differences emerged between animals with different lactation persistency at d 105 (Pd 105 = 0.03) until d 180 (Pd 180 < 0.01). The level of mammary apoptosis was significantly higher in the LP group than in the HP cows (Ppersistency < 0.01). In the oxygen-related variables, plasma concentration of hypoxia-inducible factor 1α (HIF-1α) was higher in the LP cows than in the HP group (Ppersistency < 0.01), especially on d 0 (Pd 0 < 0.01). Compared with HP cows, LP cows had a higher malonaldehyde (Pd 180 = 0.01) and a lower activity of inducible nitric oxide synthase (Pd 180 = 0.01) on d 180, suggesting a possible oxygen alteration between cows with different lactation persistency. RNA-sequencing analysis of the mammary gland on d 0 revealed that HIF-1 associated molecules may play a role in driving mammary gland apoptosis in dairy cows. A lower lactation persistency of dairy cows may be resulted from the altered HIF-1α in the mammary gland.

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Section: Discussionmentioning

confidence: 86%

Potential role of hypoxia in maintaining lactation persistency of dairy cows

Hu,

Luo,

et al. 2024

Anim. nutriomics

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“…Our sequencing results indicated that 109 target genes of DEMs were significantly enriched in the HIF-1 signaling pathway (ko04066), such as HIF1α , IGF1 , ARNT , PIK3CA , AKT3 , STAT3 and MAPK1 ( Supplementary Table S11 ). It has been reported that the hypoxia-inducible factor (HIF1α) acts as a key factor in lipid metabolism ( 21 ). Consequently, we decided to investigate the effects of HIF1α on the proliferation and differentiation of yak intramuscular preadipocytes, employing adenovirus-mediated overexpression and siRNA-mediated interference techniques.…”

Section: Resultsmentioning

confidence: 99%

IMF deposition ceRNA network analysis and functional study of HIF1a in yak

Luo,

Wang,

Zhang

et al. 2023

Front. Vet. Sci.

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The concentration of intramuscular fat (IMF) is a crucial determinant of yak meat quality. However, the molecular mechanisms that regulate IMF in yak remain largely elusive. In our study, we conducted transcriptome sequencing on the longissimus dorsi muscle tissues of yaks with varying IMF contents. We then filtered differentially expressed genes (DEGs), microRNAs (DEMs), and long non-coding RNAs (DELs) to elucidate potential regulatory pathways of adipogenesis in yaks. Overall, our research sheds light on an array of potential mRNAs and noncoding RNAs implicated in IMF deposition and elaborates on the role of HIF1α in yaks. These findings contribute valuable insights that can serve as a guide for further research into the molecular mechanisms governing IMF deposition.

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“…Higher CDAI scores, which correspond to a diet that is rich in antioxidants, were herein found to be related to a reduction in gallstone risk. Oxidative stress is firmly established as a regulator of gallstone development ( 18 , 38 , 39 ). For example, the intake of low levels of vitamin C ( 40 ), which is among the best-characterized antioxidant micronutrients, can contribute to a greater risk of gallstone formation as a result of the disruption of the production of free radicals involved in gallstone formation through changes in the protein and lipid content of the bile.…”

Section: Discussionmentioning

confidence: 99%

Characterizing the relationships between dietary indices, gallstone prevalence and the need for gallbladder surgery in the general US population

Jiang,

Shao

2024

Front. Nutr.

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BackgroundThe dietary inflammatory index (DII) and composite dietary antioxidant index (CDAI) were developed as tools for use when seeking to assess the potential inflammatory and antioxidant activity of a given diet, respectively. The associations between these indices and gallstone incidence remain largely unexplored.ObjectiveThe present study sought to clarify how both the DII and the CDAI are related to gallstone incidence and age at first gallbladder surgery among adults in the USA.MethodsCross-sectional data from the 2017–2020 cycles of the National Health and Nutrition Examination Survey (NHANES) pertaining to 12,426 individuals were used to conduct the present study. Data from 2 days with 24-h dietary recall were employed when calculating DII and CDAI scores. Relationships between dietary indices and the incidence of gallstones were assessed through logistic regression analyses, while linear regression analyses were employed to characterize how these indices are associated with the age at first gallbladder surgery.ResultsHigher DII scores and lower CDAI scores, which, respectively, denote diets with greater inflammatory potential and reduced antioxidant potential, were found to be associated with higher gallstone incidence even following adjustment for potential confounding factors. Smooth curve fitting suggested that the association between DII and gallstones was nearly linear, whereas that between CDAI and gallstone incidence was nonlinear. Higher DII values were also related to first gallbladder surgery at an earlier age (β = −0.64, 95% CI: −1.26, −0.02).ConclusionThese results emphasize the benefits of anti-inflammatory diets rich in antioxidants, which may help reduce gallstone incidence among adults in the USA. Higher DII scores may also predict the need for gallbladder surgery at a younger age.

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The role of hypoxia-inducible factor 1α in hepatic lipid metabolism

Cited by 6 publications

References 119 publications

Potential role of hypoxia in maintaining lactation persistency of dairy cows

Potential role of hypoxia in maintaining lactation persistency of dairy cows

IMF deposition ceRNA network analysis and functional study of HIF1a in yak

Characterizing the relationships between dietary indices, gallstone prevalence and the need for gallbladder surgery in the general US population

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