The Role of Humoral and Cellular Factors in the Stimulation of Nonspecific Resistance Induced by Endotoxin

Stimulation of Nonspecific Resistance by Radiation-Detoxified Endotoxin

“…It is also well known that repeated parenteral injections of small doses of LPS will produce endotoxin tolerance. Among the several factors that may be involved in inducing this tolerance, bacterial LPS seems to play the major role in stimulating the host's natural defenses (Milner et ai., 1971;Pusztai-Markos, 1975). This tolerance has been manifested in an immunologically nonspecific manner, where endotoxic shock could be prevented by previous applications of small doses of endotoxin or endotoxin derivatives.…”