The role of human papillomavirus in cervical adenocarcinoma carcinogenesis

Andersson, Sonia; Rylander, Eva; Larsson, Bengt; Strand, Anders; Silfversvärd, C; Wilander, Erik

doi:10.1016/s0959-8049(00)00376-2

Cited by 167 publications

(106 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A number of studies have found a lower prevalence of HPV infection associated with adenocarcinomas (70 -80%) than with squamous cell carcinomas (virtually all of which are associated with HPV using recent PCR methods) (Andersson et al, 2001;Lo et al, 2002;Clifford et al, 2003). It is not clear whether this represents a real difference Green et al, 2003;Smith et al, 2003), reproductive factors such as parity and possibly smoking (Plummer et al, in press)).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years: the UK National Case–Control Study of Cervical Cancer

et al. 2003

View full text Add to dashboard Cite

We report results on risk factors for invasive squamous cell and adenocarcinomas of the cervix in women aged 20 -44 years from the UK National Case -Control Study of Cervical Cancer, including 180 women with adenocarcinoma, 391 women with squamous cell carcinoma and 923 population controls. The risk of both squamous cell and adenocarcinoma was strongly related to the lifetime number of sexual partners, and, independently, to age at first intercourse. The risk of both types of cervical cancer increased with increasing duration of use of oral contraceptives, and this effect was most marked in current and recent users of oral contraceptives. The risk of squamous cell carcinoma was associated with high parity and the risk of both squamous cell and adenocarcinoma increased with early age at first birth. Long duration smoking (20 or more years) was associated with a two-fold increase in the risk of squamous cell carcinoma, but smoking was not associated with the risk of adenocarcinoma. Further studies are needed to confirm the suggestion from this and other studies of differences in risk related to smoking between squamous cell and adenocarcinomas of the cervix. Among cancers of the uterine cervix, adenocarcinomas are much less common than squamous cell carcinomas. As for squamous cell carcinoma, human papillomavirus (HPV) infection appears to be a major risk factor for adenocarcinoma of the cervix (Kjaer and Brinton, 1993;Walboomers et al, 1999;Santos et al, 2001;Altekruse et al, 2003), but evidence on other factors that may affect the risk of adenocarcinoma is limited and not entirely consistent (Parazzini and La Vecchia, 1990;Kjaer and Brinton, 1993;Ursin et al, 1994Ursin et al, , 1996Lacey et al, 1999Lacey et al, , 2000Lacey et al, , 2001Madeleine et al, 2001;Altekruse et al, 2003). The question of whether there are substantial differences in the risk factors for adenocarcinomas and squamous cell carcinomas remains unresolved. Few epidemiological studies have been designed specifically to provide a direct comparison between adenocarcinoma and squamous cell carcinoma of the cervix, and most studies of cervical carcinoma have had too few cases of adenocarcinoma to allow full evaluation of the possible risk factors. We present here results from the UK National Case -Control Study of Cervical Cancer, a case -control study of risk factors for invasive cervical cancer in women under 45 years old at diagnosis, with 180 cases of adenocarcinoma (including adenosquamous carcinoma), 391 cases of squamous cell carcinoma and 923 population controls. Information was available for all study subjects on sexual and reproductive factors, cervical screening, body weight, smoking and the use of barrier and hormonal contraceptives. Additional information was collected on HPV serology for a subgroup of subjects, and for this subgroup results have previously been published on the relationship between HPV positivity and risk of cervical cancer (Jha et al, 1993), and on oral contraceptive use as a risk factor for cervical cancer in relati...

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years: the UK National Case–Control Study of Cervical Cancer

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Two or more biopsies at different stages of the disease were available from each patient. The cyclin E expression pattern in AC of the uterine cervix was studied using tumour samples from 19 selected patients from a larger previously described set of tumours (Andersson et al, 2001). The study has been approved by Institutional Review Boards and Ethical Committees from various participating hospitals.…”

Section: Selection and Acquisition Of Tumour Biopsiesmentioning

confidence: 99%

Parallel cyclin E and cyclin A expression in neoplastic lesions of the uterine cervix

Erlandsson

et al. 2006

Br J Cancer

Self Cite

View full text Add to dashboard Cite

Cyclin E levels are high during late G1 and early S-phase in normal cells. The cyclin E expression over the cell cycle in tumours is not fully known. The impact on patient outcome by high cyclin E levels during other parts of the cell cycle than late G1-and early S-phase is unknown. We set out to study the expression of cyclin E over the cell cycle in cervical carcinomas. Using immunofluorescence staining of cyclin A, digital microscopy, and digital image analysis, we determined which cells in a tissue section that were in S-or G2-phase. M-phase cells were detected by morphology. By simultaneously staining for cyclin E, we investigated the variation in cyclin E levels over the cell cycle in cervical carcinoma lesions. In a case -control study, in which each deceased patient was matched with a patient still alive and well after 45 years of follow-up, we found that the deceased patients had a considerably higher fraction of cyclin A-positive cells staining for cyclin E than the survivors (n ¼ 36). We conclude that parallel cyclin E and cyclin A expression is an indicator for poor outcome in cervical carcinomas. In addition, we investigated the expression pattern of cyclin E and cyclin A in consecutive biopsy samples from cervical carcinomas at different stages, as well as in human papillomavirus positive or negative adenocarcinomas in order to further study the cyclin E and cyclin A expression pattern in neoplastic lesions of the uterine cervix.

show abstract

“…There are substantial differences with respect to the exact type of hrHPV and the histological diagnosis. Adenocarcinomas are more often associated with HPV type 18 than squamous cell carcinomas (Bosch et al, 1995(Bosch et al, , 2002Andersson et al, 2001;Clifford et al, 2003). Moreover, HPV 18 has been shown to be associated with a worse prognosis than other HPV types (Hildesheim et al, 1999;Schwartz et al, 2001), but this finding has been challenged (Pilch et al, 2001).…”

Section: Incidence and Survival Of Cervical Cancer S Bulk Et Almentioning

confidence: 99%

Incidence and survival rate of women with cervical cancer in the Greater Amsterdam area

et al. 2003

View full text Add to dashboard Cite

To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a cancer registry in the Greater Amsterdam area. The incidence rate of squamous cell carcinoma decreased significantly from 9.2/100 000 women in 1988 to 5.9/100 000 in 2000 (Po0.001). The incidence rate of adenocarcinomas remained stable. After adjustment for age, stage and lymph node involvement, the relative risk of death was 1.6 times higher for patients with adenocarcinomas than for patients with squamous cell carcinoma (95% CI 1.2 -2.1). The decreased survival was related to histological type, as the effect remained significant after correction for confounding factors. Over time, the prognosis of women with squamous cell carcinoma improved significantly. No significant change was observed for women diagnosed with adenocarcinoma. These results suggest that the screening programme in The Netherlands as executed in the Greater Amsterdam area is associated with a decreased incidence and increased survival of patients with squamous cell carcinoma, but fails to detect (pre)malignant lesions of adenocarcinoma. Since more than 92% of adenocarcinomas and its precursors contain high-risk HPV, adding HPV testing to cytologic screening might improve the present screening programme in detecting adenocarcinoma and its precursor lesions.

show abstract

The role of human papillomavirus in cervical adenocarcinoma carcinogenesis

Cited by 167 publications

References 21 publications

Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years: the UK National Case–Control Study of Cervical Cancer

Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years: the UK National Case–Control Study of Cervical Cancer

Parallel cyclin E and cyclin A expression in neoplastic lesions of the uterine cervix

Incidence and survival rate of women with cervical cancer in the Greater Amsterdam area

Contact Info

Product

Resources

About