The role of human papillomavirus in oncogenic transformation and its contribution to the etiology of precancerous lesions and cancer of the larynx: A review

Nowińska, Katarzyna; Ciesielska, Urszula; Podhorska‐Okołów, Marzenna; Dzięgiel, Piotr

doi:10.17219/acem/67461

Cited by 21 publications

(16 citation statements)

References 34 publications

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“…Vocal folds are the most common site of these benign lesions. Malignant transformation is a rare occurrence, only 1–7% of laryngeal papillomas transforming into SCC [59]. …”

Section: Hpv In Hnsccmentioning

confidence: 99%

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Syrjänen

2019

Acta Cytologica

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Background: The association of human papillomavirus (HPV) with head and neck squamous cell carcinoma (HNSCC) was first described in 1982–1983 by the authors of this review. Prompted by this discovery 35 years ago, an entirely new field of HPV research has emerged, resulting in a paradigm shift from smoking and alcohol as the only etiological factors to confirmation of HNSCC as an important group of HPV-related human malignancies. Summary: In this review, the authors first describe the scope (i.e., HNSCC) by the anatomic sites of the tumors. Their important site-specific differences in epidemiology are emphasized, and the misconceptions caused by the adopted practice of pooling all tumors from these divergent anatomic sites as a single entity (HNSCC) are pinpointed. The convincing evidence of the established risk factors (smoking and alcohol) is briefly addressed, before entering in the discussion on the causal role of HPV in HNSCC pathogenesis. The global HPV prevalence in different subsets of HNSCC is summarized using the data extracted from all meta-analyses published since 2010. Of all HNSCC subsets, oropharyngeal SCC has an HPV profile distinct form all the other subsets, and the possible mechanisms explaining this intimate association with HPV are discussed. Key Messages: Recent global trends show a constant increase in HNSCC rates particularly among younger age groups. The evidence on cigarette smoking and alcohol consumption as the prime risk factors of HNSCC is overwhelming. During the past 35 years, however, increasing evidence has accumulated implicating an important causal role of HPV in HNSCC. These data have important clinical implications, HPV detection and tailored treatment strategies for HPV-positive HNSCCs currently being an integral part of the oncological management practices of HNSCC.

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“…Vocal folds are the most common site of these benign lesions. Malignant transformation is a rare occurrence, only 1–7% of laryngeal papillomas transforming into SCC [59]. …”

Section: Hpv In Hnsccmentioning

confidence: 99%

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Syrjänen

2019

Acta Cytologica

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“…HPV belongs to the Papillomaviridae family and infects squamous cells and mucous Medicina 2020, 56, 81; doi:10.3390/medicina56020081 www.mdpi.com/journal/medicina membranes of humans. Prevalence of HPV in LC patients varies between 3 and 85% [12]. HPV has been shown to play a crucial role in the molecular pathways through its viral oncoproteins E6 and E7 [13].…”

Section: Introductionmentioning

confidence: 99%

Combined Effect of HPV and Several Gene SNPs in Laryngeal Cancer

Stumbrytė-Kaminskienė

Gudlevičienė

Dabkevičienė

et al. 2020

Medicina

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Background and objectives: Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck tumors. The molecular mechanism of LSCC remains unclear. The aim of this study was to evaluate the prevalence of Human papillomavirus (HPV) and single nucleotide polymorphisms (SNPs) of TP53, MDM2, MDM4, MTHFR, CASP8, and CCR5 genes in LSCC, and to assess their correlations with patient survival. Materials and Methods: 49 LSCC patients were enrolled in this study. PCR and qRT-PCR were used to detect, identify, and quantify HPV. SNPs were genotyped using PCR and PCR-RFLP. Results: By analyzing the interactions of the SNPs of the genes with clinical parameters, the majority of patients with lymph node status (N1,2) were identified as carriers of MDM2 T/G, CASP8 ins/del, CCR5 wt/wt SNP. Cluster analysis showed that patients with MDM2 T/T SNP survive longer than patients identified as CASP8 ins/ins, MTHFR C/C, and MDM4 A/A variant carriers; meanwhile, LSCC patients with MDM2 T/T polymorphic variant had the best survival. Multivariate analysis showed that HPV-positive patients without metastasis in regional lymph nodes (N0) and harboring CASP8 ins/del variant had the best survival. Meanwhile, HPV-negative patients with identified metastasis in lymph nodes (N1 and N2) and CASP8 ins/del variant had poor survival. Conclusions: This finding suggests patients survival prognosis and tumor behavior are different according HPV status, SNP variants, and clinical characteristics of the LSCC.

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“…The detection of human papilloma virus (HPV) load depends on the processing method, i.e., polymerase chain reaction, in situ hybridization or immunohistochemistry staining. 29 Several small cohorts have failed to demonstrate a positive association between HPV with laryngeal premalignancy. [30][31][32] There is a need for substantial high quality evidence to demonstrate either a causal effect or negative relationship between HPV and laryngeal dysplasia.…”

Section: Risk Factor Reduction and Chemopreventionmentioning

confidence: 99%

Laryngeal Dysplasia: What does the Evidence Tell Us?

Balasubramanian¹,

Paleri²

2017

International Journal of Head and Neck Surgery

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Management of laryngeal dysplasia often poses a clinical conundrum, especially so with its unpredictable propensity for malignant transformation. The wide heterogeneity in published results and the dearth of level I evidence makes it challenging to arrive at a consensus or best practice guidelines. In 2010, ENT UK had developed such a guideline based on critical analysis of previously published data and professional opinion. This article examines the available evidence, and attempts to highlight the best possible modalities in investigation and management strategies as objectively as possible.

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The role of human papillomavirus in oncogenic transformation and its contribution to the etiology of precancerous lesions and cancer of the larynx: A review

Cited by 21 publications

References 34 publications

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

HPV in Head and Neck Carcinomas: Different HPV Profiles in Oropharyngeal Carcinomas – Why?

Combined Effect of HPV and Several Gene SNPs in Laryngeal Cancer

Laryngeal Dysplasia: What does the Evidence Tell Us?

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