The role of HPV DNA testing in the follow-up period after treatment for CIN: a systematic review of the literature

Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers

“…[1][2][3][4][5] It has been shown that in the majority of CIN 1 lesions that spontaneously regress the viral DNA is no longer detectable by highly sensitive techniques, suggesting immune mediated viral clearance. 9,10 Such spontaneously regressing lesions do contain higher numbers of CD8 T cells compared with the persistent lesions. 11 Also, after cryo or thermal ablation of a CIN lesion,~85% of post treatment cervices will be negative for the HPV type that caused the infection.…”

Human Papillomavirus Infection After Treatment for High-Grade Cervical Intraepithelial Neoplasia

“…A systematic review of studies concerning HPV DNA testing in the follow-up period after treatment for cervical intraepithelial neoplasia indicates that among women in whom the treatment was considered to be successful, 84.2% had a negative posttreatment HPV DNA test and 15.8% a positive one. The corresponding rates for cases with treatment failures were 17.2% and 82.8%, respectively (21). Furthermore, in a study Verguts et al reported that all women with recurrent CIN were high risk HPV positive (29).…”

Role of the HPV DNA Test in Follow-up of Treated Cervical Intraepithelial Neoplasia in Bangladesh

“…Several studies also revealed that HPV testing using HC II was sensitive test of cure and was superior to either cytology or colposcopy (Nobbenhuis et al, 2001;Paraskevaidis et al, 2004;Kitchener et al, 2008). More studies in Korea and Italy discovered that HPV testing was the most sensitive mean of identifying persistence or early relapse and is therefore capable of optimizing follow-up after the treatment of high-grade CIN (Jeong et al, 2009;Kang et al, 2010;Ribaldone et al, 2010).…”