The Role of Hormone Replacement Therapy in the Prevention of Postmenopausal Heart Disease

Mosca, Lori

doi:10.1001/archinte.160.15.2263

Cited by 78 publications

(47 citation statements)

References 151 publications

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“…Elevations in Lp(a) have been associated with coronary heart disease and thrombotic stroke (25)(26)(27). The mechanism of this relationship is not known, but it is thought that because apoA and plasminogen are homologous, elevated levels of Lp(a) may interfere with fibronolysis and therefore promote thrombosis (2).…”

Section: Results -mentioning

confidence: 99%

“…ome studies have found the use of hormone replacement therapy (HRT) to be associated with a better cardiovascular health profile in healthy postmenopausal women, whereas others have found no benefits (1)(2)(3)(4)(5)(6). Epidemiological research on the potential benefits of HRT use in postmenopausal women with diabetes is also inconclusive (7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

“…After menopause there is an increase in dyslipidemia, especially reduced levels of HDL. In addition to HDL changes, menopause is also accompanied by changes in apolipoprotein (apo)A and apoB, fibrinogen, and hyperinsulinemia (1)(2)(3)5,8).…”

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confidence: 99%

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Hormone Replacement Therapy and Its Relationship to Lipid and Glucose Metabolism in Diabetic and Nondiabetic Postmenopausal Women

et al. 2002

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OBJECTIVE -Among postmenopausal women, those with diabetes experience more cardiovascular diseases than those without diabetes. We examine the relationship of hormone replacement therapy (HRT) with indicators of lipid and glucose metabolism using a national sample of diabetic and nondiabetic postmenopausal women. RESEARCH DESIGN AND METHODS -We used data from the Third NationalHealth and Nutrition Examination Survey, conducted from 1988 to 1994. A total of 2,786 postmenopausal women aged 40 -74 years participated in an oral glucose tolerance test, had blood drawn for lipid assessment, and responded to HRT questions. RESULTS -Our results show that postmenopausal women with diabetes had increased dyslipidemia compared with nondiabetic women. Among diabetic women, current users of HRT had significant different lipid and glucose control levels than never users of HRT for the following variables: total cholesterol (225 vs. 241 mg/dl), non-HDL (169 vs. 188 mg/dl), apoA (171 vs. 147 mg/dl), fibrinogen (306 vs. 342 mg/dl), glucose (112 vs. 154 mg/dl), insulin (16.81 vs. 22.6 uU/ml), and GHb (6.03 vs. 7.13 mg/dl).CONCLUSIONS -Diabetic and nondiabetic postmenopausal women currently taking HRT had better lipoprotein profile than never or previous users of HRT. Diabetic women currently taking HRT had better glycemic control than never or previous users of HRT.

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Section: Results -mentioning

confidence: 99%

mentioning

confidence: 99%

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Hormone Replacement Therapy and Its Relationship to Lipid and Glucose Metabolism in Diabetic and Nondiabetic Postmenopausal Women

et al. 2002

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“…This would be expected to reduce the risk of thrombotic events, but large studies would be required to confirm any clinically relevant effect. Although case -control analysis indicates that current hormone replacement therapy may increase the risk of thrombosis during the first year of use 32 , numerous studies have consistently shown that hormone replacement therapy reduces cardiovascular events and mortality 33 , and the relationships remain under debate.…”

Section: Discussionmentioning

confidence: 99%

Effects of tibolone and continuous combined hormone replacement therapy on bleeding rates, quality of life and tolerability in postmenopausal women

Huber¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To compare the effects of tibolone and conjugated equine oestrogens continuously combined with medroxyprogesterone acetate on bleeding rates, quality of life (QoL) and tolerability. Design A double-blind, randomised comparative trial.Setting Thirty-seven centres in six European countries.Population Five hundred and one postmenopausal women, under 65 years of age with an intact uterus.Interventions For 12 months, women received daily treatment with tibolone 2.5 mg (n ¼ 250), or conjugated equine oestrogens 0.625 mg continuously combined with medroxyprogesterone acetate 5 mg (CEE-MPA, n ¼ 251). Main outcome measures The primary outcome was vaginal bleeding rate during cycles 4 -6. The secondary outcomes were vaginal bleeding rate during cycles 1 -3, 7-9 and 10 -13, cumulative bleeding rate, QoL, wellbeing, climacteric symptoms, urogenital complaints and tolerability. Results Treatment with tibolone led to a significantly lower bleeding rate during cycles 4 -6 compared with CEE -MPA (15.0% vs 26.9%; P ¼ 0.004); there was a similar difference during cycles 1-3. Both treatments improved QoL, wellbeing, climacteric symptoms and urogenital complaints. By intent-to-treat analysis, tibolone significantly improved sexual drive, interest and/or performance, compared with CEE -MPA at 12 months ( P ¼ 0.017). Although both treatments were well tolerated, there was a significantly lower incidence of breast tenderness with tibolone than CEE -MPA (2.4% vs 17.1%; P < 0.001). Conclusion The vaginal bleeding rate during cycles 4-6 was significantly lower in women using tibolone.Both treatments improved QoL, wellbeing, climacteric symptoms and urogenital symptoms. Breast tenderness was significantly less frequent with tibolone.

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“…Parece que o estrogênio exerce importante influência sobre o controle de fatores de risco cardiovascular como tônus vascular, colesterol, pressão arterial e atividade nervosa simpática periférica (Herington et al, 1994;DeMeersman et al, 1998;Minson et al, 2000;Mosca,L., 2000).…”

Section: Sistema Hormonal Femininounclassified

Avaliação da atividade nervosa simpática periférica em mulheres jovens e em pós-menopausadas

Bernardo¹

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The Role of Hormone Replacement Therapy in the Prevention of Postmenopausal Heart Disease

Cited by 78 publications

References 151 publications

Hormone Replacement Therapy and Its Relationship to Lipid and Glucose Metabolism in Diabetic and Nondiabetic Postmenopausal Women

Hormone Replacement Therapy and Its Relationship to Lipid and Glucose Metabolism in Diabetic and Nondiabetic Postmenopausal Women

Effects of tibolone and continuous combined hormone replacement therapy on bleeding rates, quality of life and tolerability in postmenopausal women

Avaliação da atividade nervosa simpática periférica em mulheres jovens e em pós-menopausadas

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