The Role of HLA Promoters in Autoimmunity

Müller‐Hilke, Brigitte; Mitchison, N. A.

doi:10.2174/138161206778559759

Cited by 28 publications

(24 citation statements)

References 55 publications

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“…Indeed, many autoimmune conditions have been associated with specific HLA loci, including type 1 diabetes, thyroiditis, celiac disease, multiple sclerosis and ankylosing spondylosis (Muller-Hilke and Mitchison, 2006). More recently, positive and negative HLA associations with infectious diseases have been reported (Hill et al , 1991; Hill et al , 1994; Ivic et al , 2007; McAulay et al , 2007; Thio et al , 2003; Thursz et al , 1995).…”

Section: Introductionmentioning

confidence: 99%

Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy

et al. 2010

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Since HLA associations with various infectious diseases have recently been reported, we examined the role of HLA class-I alleles in the development of progressive multifocal leukoencephalopathy (PML) or its outcome in 152 patients, including 123 Caucasians and 29 African-Americans. Compared to an HIV+ control population, we observed decreased frequency of HLA-A3 (p=0.03) in the Caucasian PML group, while B18 (p=0.02), was more frequent. No such difference was found among African-American PML patients. We then sought to characterize differences in HLA between PML progressors, whose survival doesn't exceed one year, and survivors. Caucasian survivors were less likely to harbor A68 (p=0.01) while African-American survivors less frequently displayed Cw4 (p=0.01). However, none of these differences reached statistical significance after Bonferroni correction for multiple testing. Further investigations are needed to assess the role of genetics in the incidence of PML or its outcome. Physicians may exercise caution in the use of immunomodulatory medications in patients whose genetic background is associated with an increased risk of PML.

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Section: Introductionmentioning

confidence: 99%

Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy

et al. 2010

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“…Extensive investigations of the polymorphic HLA alleles, which have established implications for chronic inflammation in the transplantation setting, have also led to associations with various autoimmune diseases. However, no HLA allele has been proven necessary or sufficient to cause autoimmune disease, and research is ongoing to establish a mechanism leading to disease [3]. Major drawbacks of the genespecific approach are the inefficiency of studying one gene at a time and the variability in polymorphisms among different races, requiring any gene association to be tested in multiple populations.…”

Section: Methods To Analyze Complex Genetic Traitsmentioning

confidence: 99%

Are pediatric autoimmune diseases primarily genetic diseases?

Shaw

Stevens

2008

Current Opinion in Rheumatology

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Advancing methods are leading to the discovery of genes associated with childhood autoimmune diseases. However, the genetic contribution to disease risk for any one gene remains less than 30% for most diseases, suggesting that pediatric autoimmunity is not primarily genetic in a classical sense. A combinatorial approach considering the contributions of multiple genes, mode of inheritance, and environmental influences will be required to fully understand the mechanisms of pathogenesis in pediatric autoimmune disease.

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“…The HLA region is highly polymorphic and has been linked with the predisposition or protection to multiple autoimmune disorders (reviewed in refs. [31,32]). Previous studies have shown the association between particular HLA haplotypes and GD, but HT seems to be less influenced by the HLA region [29,33].…”

Section: Human Leukocyte Antigen (Hla)mentioning

confidence: 99%

How Far Are We from Understanding the Genetic Basis of Hashimoto's Thyroiditis?

Jabrocka‐Hybel

Skalniak

Piątkowski

et al. 2013

International Reviews of Immunology

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Hashimoto's thyroiditis (HT), an autoimmune thyroid disease (AITD), is becoming more and more prevalent in the recent years. Data on family and twin studies carry evidence for strong genetic influence on AITD susceptibility and development. The most common approaches to unravel the background of those diseases are whole genome screening and candidate gene analysis. Common Hashimoto's thyroiditis and Graves' disease (GD) genes have been identified, as well as genes that are characteristic for only one of those diseases. Because of the complex nature of AITD, caused by their polygenic nature and a complex mode of inheritance, there are still more questions to be answered than answers that can be given, especially about the nature of Hashimoto's thyroiditis. There are plenty of papers concerning the pathogenesis of AITD. However, not seldom do they end up in conclusions about GD, because the results for this disease are far clearer and more unambiguous than those obtained for HT. Similarly, meta-analyses and especially reviews most often concentrate on AITD in general or on GD alone. In this review, Hashimoto's thyroiditis is the main player. It aims to review the state of the art about the background of the development of this disease.

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The Role of HLA Promoters in Autoimmunity

Cited by 28 publications

References 55 publications

Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy

Role of human leukocyte antigen class I alleles in progressive multifocal leukoencephalopathy

Are pediatric autoimmune diseases primarily genetic diseases?

How Far Are We from Understanding the Genetic Basis of Hashimoto's Thyroiditis?

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