The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population

Silva, Ana Martins; Pereira, Clara; Bettencourt, Andreia; Carvalho, Cláudia; Couto, Ana Rita; Leite, Maria Isabel; Marta, Mónica; Freijo, Marta; Costa, Paulo; Mendonça, Denisa; Monteiro, L.; Bruges-Armas, Jácome; Martins, Berta

doi:10.1016/j.jns.2007.02.033

Cited by 40 publications

(32 citation statements)

References 40 publications

(58 reference statements)

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“…The recruited patients originated from south west of Iran. Our results are in line with most of the other previous studies in different ethnic groups in Iran [5][6][7]9] and European populations [12][13][14][15]25]. So we can conclude that HLA-DRB1*1501 can be considered as a strong genetic risk factor for MS in our population.…”

supporting

confidence: 92%

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Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Delfan

Galehdari

Kazeminejad

et al. 2017

Zahedan J Res Med Sci

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Background: Multiple sclerosis (MS) is a demyelinating, autoimmune and neurodegenerative disease of the central nervous system (CNS). The pathogenesis of this disease is still unknown, although there are evidences of environmental factors affecting subjects with genetic predisposition factors. The contribution of HLA-DRB1*1501 to MS risk has been replicated and confirmed in most population-based studies. Since there are no data with respect to the association of HLA-DRB1*1501 and MS in Khuzestan province. Objectives: The aim of this study was to investigate the correlation of this allele with MS in Khuzestan province. Methods: In this case-control study, DRB1*1501 allele was analyzed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 200 MS patients and 200 unrelated healthy individuals, without any autoimmune disease from the same geographical region. The frequencies of the mentioned allele were compared between the patients and control group using SPSS 16 statistical software and the chi square test. Results:The results demonstrated that distribution of DRB1*1501 allele was statistically different between patient and control (41.5% vs. 22.81%, P < 0.001); significant correlation was observed among these allele with both Arab (28.84% vs. 50.84%, P = 0.005) and Persian (15.87% vs. 35.55%, P = 0.018) ethnicities; although no association was revealed between mentioned allele and disease clinical course (relapsing-remitting, secondary-progressive, progressive-relapsing and primary-progressive), expanded disability scale score (EDSS) and gender. Conclusions:The study presents association of susceptibility to multiple sclerosis in southwest of Iran with HLA-DRB1*1501 allele in both Arab and Persian ethnic; although DRB1*1501 may be is not involved in the pathogenesis of different MS disease subtypes. The results are consistent with most of the other studies in Iran; and also most studies in European populations.

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confidence: 92%

“…In most studies that have been performed in European populations, the frequency of HLA-DRB1*1501 in patients have been more than that of the controls [12][13][14][15][16][17][18]. In non-European populations, such as Brazilian and AfricanAmericans, also the association of HLA-DRB1*1501 and MS has been shown [19,20].…”

Section: Discussionmentioning

confidence: 99%

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Delfan

Galehdari

Kazeminejad

et al. 2017

Zahedan J Res Med Sci

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“…In particular, a previous Brazilian study showed that the DRB1*15:01 allele confers ethnicity-dependent MS susceptibility in Caucasian patients, whereas that the DQB1*06:02 allele confers genetic susceptibility regardless of ethnicity 8 . In addition, the HLA-DRB1*15 allelic group has been associated with MS in samples from Brazil 9 and Portugal 11, 12 , the European country that originally colonized Brazil.…”

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confidence: 99%

The CIITA genetic polymorphism rs4774C in combination with the HLA-DRB115:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females

Paradela

Alves-Leon

Figueiredo

et al. 2015

Arq. Neuro-Psiquiatr.

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The objective of this study was to investigate the association between the HLA alleles at the DQA1, DQB1 and DRB1 loci, the CIITA genetic polymorphisms -168A/G and +1614G/C, and susceptibility to multiple sclerosis (MS) in a sample from Rio de Janeiro State, Brazil. Furthermore, we wished to determine whether any of these associations might be more significant in women compared with men. DNA samples from 52 relapsing-remitting MS (RRMS) patients and 126 healthy controls matched for sex and age were analyzed. We identified a significant HLA-DRB1*15:01-MS association that was female-specific (Odds Ratio (OR) = 4.78; p = 0.001). Furthermore, we observed that the +1614G/C mutation in combination with the HLA-DRB1*15:01 allele increased susceptibility to MS in females (OR = 4.55; p = 0.01). Together, these findings highlight the polygenic nature of MS.

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“…However, associations with neurological and cognitive outcomes are less consistent. While some studies have found greater disability in HLA-DRB*1501 positive individuals (Okuda et al, 2009), other have found no (Barcellos et al, 2003) or less severe effects (Silva et al, 2007).…”

Section: T-cell Mediated Inflammatory Response Against Myelin (Internmentioning

confidence: 99%

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

Yaldizli

Sethi

Pardini

et al. 2016

Multiple Sclerosis and Related Disorders

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The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population

Cited by 40 publications

References 40 publications

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

The CIITA genetic polymorphism rs4774C in combination with the HLA-DRB115:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

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The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population

Cited by 40 publications

References 40 publications

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

Analysis of HLA-DRB1*1501 in Multiple Sclerosis Patients in Khuzestan Province, Iran

The CIITA genetic polymorphism rs4774*C in combination with the HLA-DRB1*15:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females

HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis

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The CIITA genetic polymorphism rs4774C in combination with the HLA-DRB115:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females