The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

Yamauchi, Kohei; Ogasawara, Masahito

doi:10.3390/ijms20071733

Cited by 94 publications

(82 citation statements)

References 69 publications

(85 reference statements)

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“…However, previous clinical trials with antihistamines in the asthma treatment were not successful. This happens because asthma is an extremely complex disease that involves more than just histamine as a pathogenic mediator . However, antihistamines may have a role in patients with allergic asthma and rhinitis.…”

Section: Indications In Childrenmentioning

confidence: 99%

Antihistamines: ABC for the pediatricians

Parisi

Licari

Papale

et al. 2020

Pediatric Allergy Immunology

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Antihistamines are currently one of the most commonly administered drugs in children. They are used to treat symptoms that depend on histamine release, namely allergic diseases, such as rhinitis, asthma, urticaria, and anaphylaxis. It is possible to distinguish first-and second-generation antihistamines. Pharmacological effects and therapeutic indications are similar, but second-generation antihistamines have fewer adverse effects because they are more selective for peripheral H1 receptors.Although they have been on the market for several years, there are still many adverse effects linked to the antihistamine safety profile, especially in the first years of life.Thus, many antihistamines are prescribed off-label, especially in children younger than 2 years of age, which is the age-group where most of the data on drug safety are lacking and many antihistamines are not recommended. This article aims to provide a practical update on the use of antihistamines in children.

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Section: Indications In Childrenmentioning

confidence: 99%

Antihistamines: ABC for the pediatricians

Parisi

Licari

Papale

et al. 2020

Pediatric Allergy Immunology

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“…Cheryl et al (2017) reported that mindfulness meditation led to a moderate improvement in lung functions in a study population composed of patients with asthma. This can be explained by the fact that mindfulness meditation is a stressreduction intervention and stress leads to histamine release which can trigger broncho-constriction and mucus hypersecretion in asthmatics (Yamauchi and Ogasawara, 2019). Kabat-Zinn et al (2017) documented that mindfulness meditation during phototherapy can increase the rate at which the halfway and the end phases of psoriatic lesions clearing is attained by patients with moderate to severe psoriasis.…”

Section: General Positive Physiological Effects Of Mindfulness Meditamentioning

confidence: 99%

Mindfulness Meditation as a Complementary Health Therapy: A Useful Import into Africa?

Ajari

2020

EUROPEAN J ENV PUBLI

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Mindfulness meditation, a very common contemplative practice used to attain a conscious state of awareness, acceptance, openness and non-reactivity, was first modified in 1979 into a complementary health therapeutic practice. This practice has, since, gained the attention of scholars globally, with the greatest surge in interest seen in the last two decades. However, in Africa, research output on the psychological construct is very limited and certified trainers of the practice are almost non-existent despite the fact that the practice has been shown to relieve stress, a factor whose level is high in the continent, and has been associated with many common disease, illnesses and other negative outcomes. There is, therefore, an overwhelming need to draw public attention towards the practice and what it can offer African healthcare systems. However, this paper takes a neutral tone while creating this needed awareness, acting just as a guide towards unravelling the complexities of the practice and not as an advocacy piece promoting its implementation in healthcare systems across Africa. It achieves this aim by discussing the major reported positive and negative physiological effects of the practice; its application in the therapy of some common physical and mental disease/illness conditions; its benefits to healthcare workers and students, and informal caregivers; its limitations; the popular criticisms levelled against it; and factors in support and against its incorporation into African healthcare systems. The discourse is concluded with recommendation of strategies for refining the practice to suit the African healthcare scene.

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“…Nasal congestion has been reported during anaphylactic episodes, and has the potential to interfere with IN epinephrine in the treatment of anaphylaxis [20,21]. During an anaphylactic or allergic event, the release of inflammatory mediators, such as histamine, contribute to vasodilation [22,23]. Increased vasodilation can result in edema and swelling of the nasal mucosa, impeding air flow and increasing nasal secretions [22,23].…”

Section: Introductionmentioning

confidence: 99%

“…During an anaphylactic or allergic event, the release of inflammatory mediators, such as histamine, contribute to vasodilation [22,23]. Increased vasodilation can result in edema and swelling of the nasal mucosa, impeding air flow and increasing nasal secretions [22,23]. However, alpha-adrenergic receptor agonists like epinephrine have known decongestant activity [24].…”

Section: Introductionmentioning

confidence: 99%

Intranasal epinephrine effects on epinephrine pharmacokinetics and heart rate in a nasal congestion canine model

et al. 2020

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Background: Histamine release and vasodilation during an allergic reaction can alter the pharmacokinetics of drugs administered via the intranasal (IN) route. The current study evaluated the effects of histamine-induced nasal congestion on epinephrine pharmacokinetics and heart rate changes after IN epinephrine. Methods: Dogs received 5% histamine or saline IN followed by 4 mg epinephrine IN. Nasal restriction pressure, epinephrine concentration, and heart rate were assessed. Maximum concentration (C max), area under plasma concentration-time curve from 1 to 90 min (AUC 1-90), and time to reach C max (T max) were measured. Clinical observations were documented. Results: In the 12 dogs in this study, nasal congestion occurred at 5-10 min after IN histamine administration versus no nasal congestion after IN saline. After administration of IN epinephrine, IN histamine-mediated nasal congestion was significantly reduced to baseline levels at 60, 80, and 100 min. There were no significant differences in C max and AUC 1-90 between histamine and saline groups after IN epinephrine delivery (3.5 vs 1.7 ng/mL, p = 0.06, and 117 vs 59 ng/ mL*minutes, p = 0.09, respectively). After receiving IN epinephrine, the histamine group had a significantly lower T max versus the saline group (6 vs 70 min, respectively; p = 0.02). Following IN epinephrine administration, the histamine group showed rapidly increased heart rate at 5 min, while there was a delayed increase in heart rate (occurring 30-60 min after administration) in the saline group. Clinical observations included salivation and emesis. Conclusion: IN histamine led to more rapid epinephrine absorption and immediately increased heart rate compared with IN saline. IN epinephrine decreased histamine-induced nasal congestion.

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The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

Cited by 94 publications

References 69 publications

Antihistamines: ABC for the pediatricians

Antihistamines: ABC for the pediatricians

Mindfulness Meditation as a Complementary Health Therapy: A Useful Import into Africa?

Intranasal epinephrine effects on epinephrine pharmacokinetics and heart rate in a nasal congestion canine model

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