The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases

Laco, Ján; Vošmiková, Hana; Nováková, V.; Čelakovský, Petr; Doležalová, Helena; Tuček, Luboš; Nekvindová, Jana; Vošmik, Milan; Čermáková, Eva; Ryška, Aleš

doi:10.1007/s00428-010-1037-y

Cited by 49 publications

(51 citation statements)

References 32 publications

(50 reference statements)

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“…Previous studies reported that the rate of HPV positivity is higher in OPSCC, especially tonsil cancer, than in OSCC [7]. Our result is consistent with these previous results: about 30 % of OPSCC patients showed HPV positivity, in contrast to 3 % of OSCC patients.…”

Section: Discussionsupporting

confidence: 93%

Differences in Expression of EGFR, Ki67 and p-EPK in Oral Cavity Squamous Cell Carcinoma

Bu¹,

Bu²,

Chen³

et al. 2016

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 93%

Differences in Expression of EGFR, Ki67 and p-EPK in Oral Cavity Squamous Cell Carcinoma

Bu¹,

Bu²,

Chen³

et al. 2016

Trop. J. Pharm Res

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“…Most publications correlating p16 expression with HPV status study mixed groups of cancers from different anatomic sites [61,81,93]. These studies are not powered to determine the sensitivity and specificity of p16 overexpression as a surrogate biomarker for HPV-mediated oral cavity carcinogenesis.…”

Section: Hpv and Oral Cavity Cancermentioning

confidence: 99%

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

216

210

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Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on ''treatment deintensification'' for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.

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“…Brown staining of tumor cell nuclei and/or cytoplasm was interpreted as positive. The p16 immunostaining was scored according to criteria set out in our previous studies [10,13] as follows: (0) absent, (+) 1-5% tumor cells stained, (++) 6-20% tumor cells stained, (+++) 21-50% tumor cells stained, and (++++) 51-100% tumor cells stained.…”

Section: Methodsmentioning

confidence: 99%

“…As a continuation of our previous study on the role of HPV in the etiopathogenesis of HNSCCs in nonsmokers [10], we included a group of smokers and also expanded the spectrum of evaluated clinicopathological parameters. The aim of the current study was to compare (i) nonsmokers to smokers, (ii) OSCCs to OPSCCs, and most importantly, (iii) HPV-positive to HPV-negative SCCs.…”

mentioning

confidence: 99%

Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status

Laco

Nekvindová²,

Nováková³

et al. 2012

neo

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The aim of this study is to evaluate the biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16INK4a (p16) expression, and human papillomavirus (HPV) status. The study sample consisted of 48 patients with OSCC and 44 patients with OPSCC. Half of the patients were nonsmokers and the other half were gender-, age-and tumor localization-matched smokers.p16 expression was detected in 17/48 (35 %) OSCCs and in 36/44 (82 %) OPSCCs and HPV DNA was present in 7/48 (15 %) OSCCs and in 35/44 (80 %) OPSCCs. The sensitivity and specificity of p16 expression for HPV DNA presence were 0.74 and 0.88, respectively.The OPSCCs were more frequently basaloid (p < 0.001) while the OSCCs were more frequently conventional (p < 0.000001). The OSCCs were more likely to recur locally and to be the cause of death (p = 0.009 in both parameters).The HPV-positive tumors were more frequently localized in oropharynx, were basaloid SCCs and were p16-and HPV-positive (p < 0.000001 in all 4 parameters). The HPV-negative tumors were more frequently localized in oral cavity (p < 0.000001), more frequently asociated with local, regional and locoregional recurence (p = 0.011, p = 0.019 and p = 0.030, respectively) and with tumor-related death (p = 0.003). There was no significant difference with regard to smoking history (p > 0.05).The survival of patients with HPV-positive tumors was significantly longer (median 112 months; 95% CI 54 -112 months) than that of patients with HPV-negative tumors (median 17 months; 95% CI 12 -39 months) (p < 0.001).The HPV status of OSCC/OPSCC is an important biological and prognostic parameter and should be examined in all cases, using PCR or immunohistochemical detection of surrogate marker p16. Smoking itself does not seem to be an important prognostic factor.

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The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases

Cited by 49 publications

References 32 publications

Differences in Expression of EGFR, Ki67 and p-EPK in Oral Cavity Squamous Cell Carcinoma

Differences in Expression of EGFR, Ki67 and p-EPK in Oral Cavity Squamous Cell Carcinoma

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status

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