The Role of High Flow Capillary Channels in the Local Oxygen Supply to Skeletal Muscle

Harrison, David K.; Birkenhake, S.; Knauf, S.; Hagen, Nathan; Beier, I.; Kessler, M.

doi:10.1007/978-1-4615-9510-6_77

Cited by 16 publications

(4 citation statements)

References 5 publications

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“…During hypoxaemia flow may be increased through such channels within the capillary network as a precautionary mechanism which ensures that oxygenated blood is immediately available through the local regulatory system should it be required to prevent the occurrence of tissue anoxia. However, the proof of this hypothesis is not supplied by these experiments alone, but through further studies which have recently been completed (Harrison, Birkenhake, Hagen & Kessler, 1988).…”

Section: Local Regulationmentioning

confidence: 99%

Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia.

Harrison

Kessler

Knauf

1990

The Journal of Physiology

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Section: Local Regulationmentioning

confidence: 99%

Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia.

Harrison

Kessler

Knauf

1990

The Journal of Physiology

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“…In various tissues and organs exist different capillary supply units. 9 Their length and diameter differ leading to variations in perfusion. 10 In addition to areas of high flow capillary units there are low flow areas causing a heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

<title>Imaging of drug effects in perfused liver</title>

2002

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Various medications affect the systemic circulation and organ oxygenation causing dilatation or constriction of blood vessels. Imminent liver failure can be generated by reduced perfusion of different origins. In this case hepatic vasodilatation would be a therapeutical approach for improving patient's condition. Our examinations have been performed in perfused rat liver using spectrometric methods. Two defined areas of the liver were measured punctually. We compared the influence of Tetramethylpyrazine and Glyceroltrinitrate on hemoglobin oxygenation (HbO 2 ) and concentration (Hb-conc.) in rat liver after application of Norepinephrine, which caused a mid decrease in hemoglobin oxygenation of 47,9 %. Both increased the HbO 2 , but differed from each other in manner of time and extent. Tetramethylpyrazine indicated a longer effect than Glyceroltrinitrate. Futhermore, HbO 2 and Hb-conc. showed a conversed relation. From the shape of the absorption spectra it is possible to derive the oxygenation of hemoglobin.

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“…Thus, central blood pressure will be stabilized, and the oxygen supply to central organs such as the brain and heart will be maintained [9]. A discrepancy between mean tissue and venous partial pressures of oxygen [17] indicates a heterogeneity of capillary flow through the organs (except the heart and kidneys). In fact, that may prove the existence of highflow capillary channels in skeletal muscle that serve a physiological function as a local reserve of oxygen.…”

Section: Misclassification Of Anaemiamentioning

confidence: 99%

Anaemia and Haemoglobin Status: A New Concept and a New Method of Assessment

Gross¹,

Gliwitzki²,

Gross³

et al. 1996

Food Nutr Bull

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Traditionally, anaemia has been determined and interpreted by the magnitude and severity of iron deficiency and the impact of intervention strategies. Internationally, it is defined as a state in which the quality and/or quantity of circulating red cells are reduced below a normal level The body employs several mechanisms during the development of anaemia to maintain the oxygen supply to the tissues. Thus, applying any quantitative cutoff point as an indicator for anaemia may lead to misclassification, since haemoglobin concentration does not necessarily reflect the level of tissue oxygen supply. Ideally, an assessment strategy should be able to determine both the degree of haemoglobin oxygenation and the haemoglobin concentration at a tissue level. The Erlangen microlightguide spectrophotometer is a non-invasive instrument that can assess both capillary blood oxygenation and relative haemoglobin concentration.

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The Role of High Flow Capillary Channels in the Local Oxygen Supply to Skeletal Muscle

Cited by 16 publications

References 5 publications

Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia.

Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia.

<title>Imaging of drug effects in perfused liver</title>

Anaemia and Haemoglobin Status: A New Concept and a New Method of Assessment

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