The role of high‐dose‐rate and pulsed‐dose‐rate brachytherapy in the management of recurrent or residual stomal tumor after total laryngectomy

Abstract

The results of our study show that HDRBT and PDRBT are feasible in previously irradiated patients with recurrent or residual stomal tumor after total laryngectomy. They provide acceptable toxicity and good palliative effect.

Image-guided interstitial high-dose-rate brachytherapy in the treatment of inoperable recurrent head and neck malignancies: An effective option of reirradiation

“…Although surgical resection constitutes the primary curative option when recurrent disease is resectable, in actuality, only a small fraction of patients are suited for an organ-sparing approach. [15][16][17][18][19][20][21][22][23][24][25][26][27][28] However, there are no well-defined recommendations for selecting patients for interventional radio-oncologic treatment and, in most cases, the decision is made individually. 10 However, it should be underlined that if locoregional disease is left untreated, the prognosis and quality of life are quite poor with sole chemotherapy offering a median survival of 6 months.…”

“…10 Thinking with the wisdom of hindsight, image-based interstitial brachytherapy has proven to be an effective alternative for this poor-prognosis population by escalating the biologically effective dose (BED) to the treatment target while ameliorating conformity. 8,[15][16][17][18][19][20][21][22][23][24][25][26][27][28] The purpose of the present work was to present 4 challenging cases with locally progressive disease of rare histopathological entities in which salvage surgery after previous EBRT in the head and neck was not possible. A number of publications have reported good local control associated with acceptable complication rates in the treatment of recurrent head and neck cancer with afterloaded brachytherapy.…”

“…A number of publications have reported good local control associated with acceptable complication rates in the treatment of recurrent head and neck cancer with afterloaded brachytherapy. 8,[15][16][17][18][19][20][21][22][23][24][25][26][27][28] The purpose of the present work was to present 4 challenging cases with locally progressive disease of rare histopathological entities in which salvage surgery after previous EBRT in the head and neck was not possible. We consider it meaningful to share this experience in order to boost acceptance for brachytherapy also in cases of larger tumor volumes and technically demanding, noncoplanar multilevel implantation, which are all aspects that deemed to be relative contraindications for brachytherapy.…”

A review of the clinical experience in pulsed dose rate brachytherapy

“…[33][34][35][36][37][38][39][40][41][42][43][44][45][46] Based on these articles, we added the article by Johansson et al, 47 which was not found in both searches, and the article of Strnad et al, 48 which was published after our search. We excluded four articles of the Erlangen group since these were the previous results from the same studies with shorter follow-up time (Tables 5 and 6).…”

“…Two studies reported data on primary or recurrent lip carcinoma. 40,47 The other five articles reported on recurrence in HN cancer, whereas Bartochowska et al 34 also did a subanalysis on recurrence in specifically larynx carcinoma.…”