The role of hepatic lipid composition in obesity‐related metabolic disease

Willis, Scott A.; Bawden, Stephen; Malaikah, Sundus; Sargeant, Jack A; Stensel, David J.; Aithal, Guruprasad P.; King, James A.

doi:10.1111/liv.15059

Cited by 29 publications

(30 citation statements)

References 151 publications

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“…1 H-MRS is a noninvasive method for assessing hepatic lipid composition. Higher indices of hepatic fatty acid saturation and lower indices of unsaturation were observed in patients with obesity-related metabolic disease[ 27 ].…”

Section: Resultsmentioning

confidence: 99%

How to select the quantitative magnetic resonance technique for subjects with fatty liver: A systematic review

Li¹,

Yang²,

Chen³

et al. 2022

WJCC

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BACKGROUND Early quantitative assessment of liver fat content is essential for patients with fatty liver disease. Mounting evidence has shown that magnetic resonance (MR) technique has high accuracy in the quantitative analysis of fatty liver, and is suitable for monitoring the therapeutic effect on fatty liver. However, many packaging methods and postprocessing functions have puzzled radiologists in clinical applications. Therefore, selecting a quantitative MR imaging technique for patients with fatty liver disease remains challenging. AIM To provide information for the proper selection of commonly used quantitative MR techniques to quantify fatty liver. METHODS We completed a systematic literature review of quantitative MR techniques for detecting fatty liver, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. Studies were retrieved from PubMed, Embase, and Cochrane Library databases, and their quality was assessed using the Quality Assessment of Diagnostic Studies criteria. The Reference Citation Analysis database ( ) was used to analyze citation of articles which were included in this review. RESULTS Forty studies were included for spectroscopy, two-point Dixon imaging, and multiple-point Dixon imaging comparing liver biopsy to other imaging methods. The advantages and disadvantages of each of the three techniques and their clinical diagnostic performances were analyzed. CONCLUSION The proton density fat fraction derived from multiple-point Dixon imaging is a noninvasive method for accurate quantitative measurement of hepatic fat content in the diagnosis and monitoring of fatty liver progression.

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Section: Resultsmentioning

confidence: 99%

How to select the quantitative magnetic resonance technique for subjects with fatty liver: A systematic review

Li¹,

Yang²,

Chen³

et al. 2022

WJCC

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“…Increased de novo lipogenesis also plays an important role in the development of hepatic steatosis in NAFLD patients. 15 It is known that patients with NAFLD have fatty acid mitochondrial oxidation defects. This is due to effects on mitochondrial structure and function.…”

Section: Cardiovascular Risk and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Atherosclerosis and Non-Alcoholic Fatty Liver Disease

Balta

2022

Angiology

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Non-alcoholic fatty liver disease (NAFLD) is a common disease defined by excess fat deposition in the liver. The course of NAFLD is not fully understood, however, some pathogenic mechanisms have been identified. Accumulation of fat in liver cells is associated with insulin resistance, central obesity, triglyceride accumulation in the liver and hepatic fatty acid metabolism dysregulation that cause steatosis. The other process leads to hepatocyte inflammation and necrosis, which leads to severe hepatic disease; non-alcoholic steatohepatitis. Many clinical studies have underlined the link between NAFLD and atherosclerosis. NAFLD may alter the balance lipid-glucose metabolism as well as increase the risk of hypertension and systemic inflammation. This results in a greater risk of vascular events. The present review considers the link between NAFLD and atherosclerosis.

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“…Obesity is a primary antecedent to NAFLD, which makes them closely related ( 207 ). Up to 80% of NAFLD patients are obese, and only 16% of individuals with a normal body mass index (BMI) and without metabolic risk factors are obese ( 208 , 209 ).…”

Section: Mutual Mediation Mechanisms Between Major Depressive Disorder and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Interaction Mechanisms Between Major Depressive Disorder and Non-alcoholic Fatty Liver Disease

Shao

Jiang

et al. 2021

Front. Psychiatry

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Major depressive disorder (MDD), which is highly associated with non-alcoholic fatty liver disease (NAFLD), has complex pathogenic mechanisms. However, a limited number of studies have evaluated the mutual pathomechanisms involved in MDD and NAFLD development. Chronic stress-mediated elevations in glucocorticoid (GC) levels play an important role in the development of MDD-related NAFLD. Elevated GC levels can induce the release of inflammatory factors and changes in gut permeability. Elevated levels of inflammatory factors activate the hypothalamic–pituitary–adrenal (HPA) axis, which further increases the release of GC. At the same time, changes in gut permeability promote the release of inflammatory factors, which results in a vicious circle among the three, causing disease outbreaks. Even though the specific role of the thyroid hormone (TH) in this pathogenesis has not been fully established, it is highly correlated with MDD and NAFLD. Therefore, changing lifestyles and reducing psychological stress levels are necessary measures for preventing MDD-related NAFLD. Among them, GC inhibitors and receptor antagonists may be key in the alleviation of early and mid-term disease progression. However, combination medications may be important in late-stage diseases, but they are associated with various side effects. Traditional Chinese medicines have been shown to be potential therapeutic alternatives for such complex diseases.

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The role of hepatic lipid composition in obesity‐related metabolic disease

Cited by 29 publications

References 151 publications

How to select the quantitative magnetic resonance technique for subjects with fatty liver: A systematic review

How to select the quantitative magnetic resonance technique for subjects with fatty liver: A systematic review

Atherosclerosis and Non-Alcoholic Fatty Liver Disease

Interaction Mechanisms Between Major Depressive Disorder and Non-alcoholic Fatty Liver Disease

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