The role of heparin binding surfaces in the direction of endothelial and smooth muscle cell fate and re-endothelialization

Yang, Zhilu; Tu, Qiufen; Wang, Jin; Huang, Nan

doi:10.1016/j.biomaterials.2012.06.055

Cited by 113 publications

(121 citation statements)

References 50 publications

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“…However, the effects of heparin on EC growth have long been controversial [23][24][25][26]. This study demonstrates that immobilized heparin prominently promotes EC attachment and proliferation, which is consistent with some recent studies [23,24]. Moreover, it was found that the CD31 expression was significantly up-regulated by immobilized heparin.…”

Section: Discussionsupporting

confidence: 92%

“…Most previous studies focused on enhancing EC attachment and growth on various modified material surfaces; however, little attention has been paid to the competitive growth of ECs over SMCs in vivo [23,26]. Recent studies demonstrated that the competitive ability of ECs over SMCs played a more important role than the quantity of ECs in the formation of a pure and confluent endothelial layer in vivo, which is essential for preventing restenosis [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…However, the effects of heparin on EC proliferation are ambiguous. While some groups have demonstrated the enhancement of EC growth induced by heparin [23,24], other groups did not detect significant effects of heparin on EC growth [25,26].…”

Section: Introductionmentioning

confidence: 96%

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Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography

Ding

Yang

et al. 2015

Acta Biomaterialia

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography

Ding

Yang

et al. 2015

Acta Biomaterialia

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“…68 An ideal cardiovascular implant should possess excellent hemocompatibility, directing the fate of vascular cells, as well as anti-infective and anti-inflammatory properties. 54 Herein, we developed a biomimetic multifunctional surface by grafting hydrophilic HPMA, antimicrobial EgMA, and EC adhesive peptide REDV. First, we used activators that were regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) technique to graft random copolymers of HPMA and EgMA in different molar ratios onto a PCU surface.…”

Section: Introductionmentioning

confidence: 99%

“…[50][51][52][53] In addition, other investigators have immobilized antibodies, growth factors, proteins and genes to improve the interaction of implants with ECs to accelerate endothelialization. 38,51,[54][55][56][57][58][59] Infections have become one of the main causes of patient morbidity and mortality. 60,61 In particular, infections caused by surface-bound bacterial cells are a major problem in clinical surgeries and implantation operations.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial surfaces grafted random copolymers with REDV peptide beneficial for endothelialization

et al. 2015

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Polycarbonate urethane (PCU) elastomeric materials have been developed for vascular prosthesis applications, because of their excellent mechanical and physical properties. However, thrombosis and inflammation often limit their usage as small-diameter vascular grafts. Herein, we focused on the design and functionalization of a PCU elastomer with enhanced hemocompatibility, rapid endothelialization and antimicrobial properties. An atom transfer radical polymerization (ATRP) technique was utilized to graft random copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) and eugenyl methacrylate (EgMA) onto a PCU surface, and subsequently the cysteine-terminated CREDV peptide sequence was directly linked onto the surface by a thiol-ene click reaction to prepare a series of REDV peptide functionalized surfaces. The chemical compositions of the modified surfaces were quantified by X-ray photoelectron spectroscopy (XPS), and the hydrophilicity was evaluated by water contact analysis and water uptake.The surface hemocompatibility was verified by platelet adhesion assays, and the results demonstrated that platelet adhesion was significantly reduced on the modified surface. More importantly, the functionalized surfaces with high hydrophilicity and cell specific adhesive REDV peptide could selectively enhance the adhesion and proliferation of human umbilical vein endothelial cells (HUVECs) but they suppressed these behaviors in human arterial smooth muscle cells (HASMCs). Moreover, these surfaces showed excellent antibacterial properties, which originate from the EgMA moieties of the copolymers. The successful fabrication of multifunctional surfaces with excellent hemocompatibility, rapid endothelialization, and good antimicrobial activity through a feasible route could be an attractive platform for tissue engineering applications.

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Flexible Transient Bioelectronic System Enables Multifunctional Active‐Controlled Drug Delivery

Liu

Jia

Yang

et al. 2023

Adv Funct Materials

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On-demand drug delivery systems (DDSs) have tremendous promise for clinical in vivo personalized drug delivery. However, the current DDSs are monofunctional and unable to meet the individualized needs of patients. Herein, a biodegradable multifunctional active-controlled drug delivery system (ADDS) is reported. The device can be implanted in various tissues with valves controlled by the deactivation of magnesium (Mg) for rapid drug release from drug reservoirs and long-term drug delivery with the biodegradation of the ADDS. Multiple chambers are constructed by designing a structure with tandem Mg valves and aligning them in the z-axis direction, allowing the system to deliver drugs in a pulsatile or sequential manner. The biodegradability of the entire system minimizes the potential side effects of the ADDS. The application of the device for drug delivery in rats confirmed its ability to perform pulsatile delivery in vivo. The excellent biocompatibility and dual timeline drug delivery capability of this system are demonstrated with cellular and in vitro vascular bioreactors. This multifunctional ADDS will play an important role in precise drug delivery in the treatment of chronic diseases and diseases with complications.

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The role of heparin binding surfaces in the direction of endothelial and smooth muscle cell fate and re-endothelialization

Cited by 113 publications

References 50 publications

Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography

Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography

Antimicrobial surfaces grafted random copolymers with REDV peptide beneficial for endothelialization

Flexible Transient Bioelectronic System Enables Multifunctional Active‐Controlled Drug Delivery

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