The role of heat shock protein 60, vascular endothelial growth factor and antiphospholipid antibodies in Behçet disease

Shaker, Olfat G.; El-Deen, Mohamed A Ay; Hadidi, Heba El; Grace, B.D.; Sherif, HossamM; Halim, Ashraf Abdel

doi:10.1111/j.1365-2133.2006.07536.x

Cited by 47 publications

(28 citation statements)

References 29 publications

(40 reference statements)

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“…Most other studies conducted on other HSPs, like HSP-60 or HSP-65 and BD, illustrated that increased serum values of these proteins associate with different clinical manifestations including uveitis [2,7,9,15]. Among the few studies in which the relationship between BD and serum values of HSP-and anti-HSP-70 has been determined, the most important one is Birtas-Atesoglu et al study.…”

Section: Discussionmentioning

confidence: 98%

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Diagnostic Yield of Heat Shock Protein 70 (HSP‐70) and Anti‐HSP‐70 in Behcet‐Induced Uveitis

et al. 2013

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Heat shock proteins (HSPs) are intracellular proteins with pro-and antiinflammatory actions, playing an important role in the pathogenesis of Behcet's disease (BD). Diagnosis of BD uveitis in early stages is still problematic, thus this study was undertaken to determine diagnostic values of serum HSP-and anti-HSP-70 in BD uveitis. Serum levels of HSP-and anti-HSP-70 were measured in 53 patients with BD (26 with and 27 without uveitis). In control group, 25 age-and sex-matched idiopathic uveitis patients were enrolled consecutively. Both groups had no medical problems save uveitis at the time of sampling. Confounders like medications were analysed subsequently. HSP-and anti-HSP-70 values were measured by commercial ELISA kits. Data were analysed by SPSS 11.5 and MEDCALC 11.5.1 software. The Mean HSP-70 serum levels were different among aforementioned subgroups (P = 0.001, ANOVA). They were elevated in BD uveitis compared with BD without uveitis (4.84 AE 4.21 versus 2.24 AE 2.08 ng/ml; P = 0.045). HSP-70 in sera of BD uveitis was also higher than that parameter in patients with idiopathic uveitis (4.84 AE 4.21 versus 2.37 AE 3.30 ng/ml; P = 0.001; cut-off point value 1.0 9 ng/ml, 95% CI 0.61-0.86, P = 0.0002, ß = 0.06). However, there was not any statistical difference among those groups in the serum anti-HSP-70 levels (P = 0.63, ANOVA). Multiple regression analysis demonstrated that among different confounders, only prednisolone increases and BD uveitis decreases HSP-70 levels independently. This prospective cross-sectional study suggested that HSP-70 serum level is impressed over the course of BD uveitis, and it could be utilized to diagnose or predict developing it.

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Section: Discussionmentioning

confidence: 98%

“…Genetic and environmental factors have been related to disease susceptibility, but their exact role is uncertain and the etiopathogenesis of the disease should be still clarified [2].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Yield of Heat Shock Protein 70 (HSP‐70) and Anti‐HSP‐70 in Behcet‐Induced Uveitis

et al. 2013

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“…hsp-65 und hsp-60 teilen Antigenität mit der oralen Mukosa und wurden in den Epidermiszellen von Behçet-Hautläsionen nachgewiesen [5,9]. Antikörper gegen hsp wurden bei Behçet-Patienten mit Gehirnbeteiligung im Serum [11] und im Liquor [12] gefunden. Somit könn-ten hsp-65 und hsp-60 Immunmechanismen triggern, die die gesteigerte Aktivität von γ-δ-T-Lymphozyten und den Anstieg von Zytokinen wie Inter feron-(IFN-)γ, Interleukin-(IL-)1, IL-4, IL-6, IL-8, IL-12, TNF-α und "vascular endothelial growth factor" [11] erklären, ebenso wie das Vorkommen von zirkulierenden Immunkomplexen und Störungen der Komplementspiegel.…”

Section: äTiopathogeneseunclassified

“…Antikörper gegen hsp wurden bei Behçet-Patienten mit Gehirnbeteiligung im Serum [11] und im Liquor [12] gefunden. Somit könn-ten hsp-65 und hsp-60 Immunmechanismen triggern, die die gesteigerte Aktivität von γ-δ-T-Lymphozyten und den Anstieg von Zytokinen wie Inter feron-(IFN-)γ, Interleukin-(IL-)1, IL-4, IL-6, IL-8, IL-12, TNF-α und "vascular endothelial growth factor" [11] erklären, ebenso wie das Vorkommen von zirkulierenden Immunkomplexen und Störungen der Komplementspiegel. Immunhistologisch findet man Ablagerungen von Immunglobulin und Komplement innerhalb des Gefäßlumens und um die Gefäßwand, mit Infiltration durch T-Helferzellen, B-Zellen und Neutrophile.…”

Section: äTiopathogeneseunclassified

Morbus Adamantiades-Behçet

Störk

Kneitz

Bröcker³

et al. 2008

Med Klin

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Behçet's disease is a chronic relapsing systemic vasculitis of unknown etiology, affecting predominantly oral and genital mucocutaneous tissues and also the eyes. The disease is spread worldwide with a higher prevalence rate in countries along the ancient Silk Route, but it is rare (1-10/100,000) in Central and Northern Europe. Genetic, environmental, immunologic, inflammatory and rheologic factors are involved in the pathogenesis and the course of the disease. Any vascularized organ may be affected. Eye involvement is frequent, and may eventually result in loss of vision. Further important complications are cerebral manifestations, thrombotic syndromes, and arterial aneurysms with a high risk of rupture. Diagnosis and therapy of Behçet's disease are best managed by an interdisciplinary team. Skin lesions may be controlled by systemic treatment with colchicine, alternatively with dapsone, and in severe cases with thalidomide. Active systemic disease should be treated more aggressively using immunosuppressants. Despite advances in treatment relapses are still frequent, and systemic disease remains associated with an adverse prognosis.

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“…HSP60/65 is an immunodominant antigen that is derived from mammalian/bacterial 60/65 kDa HSP. The increased expression of both self and infective stress proteins and the extensive sequence homology and cross-reactivity between microbial HSPs (better known as groEL) and human HSPs led to the concept that HSPs might be involved in the etiopathogenesis of BD [63][64][65][66]. In addition to the HSP60, other HSPs (such as αB-crystallin and HSP70) have been suggested to play a role in the pathogenesis of BD [12,[67][68][69][70][71][72].…”

Section: Heat Shock Proteinsmentioning

confidence: 99%

Behcet’s disease: from heat shock proteins to infections

2014

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Background: Behcet's disease (BD) is a chronic, inflammatory multisystemic condition of unknown etiology. Although the cause of BD is not clear, it is believed to be the result of an autoimmune process triggered by an infectious or environmental agent (possibly local to a geographic region) in a genetically predisposed individual. Objective: To detail current knowledge of the role of microorganisms in the pathogenesis of BD and review the infectious etiology of this disease. Methods: The review based on publication in SCOPUS, Science direct, and PubMed. Results: A microbial infection has been implicated in the development of the disease to explain the strong inflammatory reactions observed, the activation of monocytes and macrophages, and the induction of proinflammatory cytokines and chemokines detected. Common factors linking some of the possible pathogenetic agents are extrinsically induced tissue stress or heat shock proteins, which react with host tissues and elicit significant T-helper type 1 cell responses. Conclusion: Based on collected data, we conclude that the microorganisms discussed seem to participate and, at least in part, act as triggers during the course of BD. By clarifying the microbial associations of BD and finding its etiology, particularly the causative antigens leading to BD, it would be easier to suggest more effective treatment and preventive strategies for this disease.

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The role of heat shock protein 60, vascular endothelial growth factor and antiphospholipid antibodies in Behçet disease

Abstract: An elevated serum level of VEGF may be a risk factor for the development of ocular disease contributing to poor visual outcome.

Cited by 47 publications

References 29 publications

Diagnostic Yield of Heat Shock Protein 70 (HSP‐70) and Anti‐HSP‐70 in Behcet‐Induced Uveitis

Diagnostic Yield of Heat Shock Protein 70 (HSP‐70) and Anti‐HSP‐70 in Behcet‐Induced Uveitis

Morbus Adamantiades-Behçet

Behcet’s disease: from heat shock proteins to infections

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