The Role of Heart Rate Variability (HRV) in Different Hypertensive Syndromes

Yugar, Louise Buonalumi Tacito; Dinamarco, Nelson; Sedenho-Prado, Luis Gustavo; Moreno, Beatriz; Rubio, Tatiane de Azevedo; Fattori, André; Rodrigues, Bruno; Vilela-Martin, José Fernando; Moreno, Heitor

doi:10.3390/diagnostics13040785

Cited by 26 publications

(9 citation statements)

References 129 publications

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“…Several studies have reported that hypertensive individuals have lower values of time-domain HRV parameters. Some studies have also suggested that the LF/HF ratio, which is an indicator of sympathovagal balance, is increased in hypertensive individuals [18,19,20]. However, we found no difference in the LF/HF ratio between normotensive and hypertensive individuals.…”

Section: Discussioncontrasting

confidence: 85%

Heart Rate Variability in Normotensive and Hypertensive Adults After a Year of Receiving Oxford/AstraZeneca COVID-19 Vaccine: A Cross-Sectional Observational Study

Sunita¹,

Manjulata²,

Mondal³

et al. 2023

Cureus

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Background and aimHeart rate variability (HRV) helps in assessing the autonomic nervous system's function, which has been implicated in cardiovascular disease risk. HRV has been found to be deranged in hypertension. In addition, studies have shown that COVID-19 infection and vaccination can affect HRV. However, the long-term effect of HRV on hypertension has not been explored after COVID-19 vaccination. The objective of this study was to observe the HRV in hypertensive adults after one year of receiving the Oxford/AstraZeneca COVID-19 vaccine and to compare it with normotensive adults. MethodsThe study included 105 normotensives (blood pressure below 120/80 mmHg) and 75 hypertensive participants who had received the Oxford/AstraZeneca COVID-19 vaccine one year prior. HRV was measured using the PowerLab system (ADInstruments) with the participants in a sitting posture. The HRV parameters assessed included the time domain, frequency domain, and nonlinear measures. Data were presented in descriptive and inferential statistical terms, and the parameters of two groups of individuals were compared by either an unpaired t-test or the Mann-Whitney U test. ResultsA total of 105 normotensive participants with a mean age of 42.51 ± 9.28 years and 75 hypertensive participants with a mean age of 44.24 ± 10.19 years comprised the sample (p=0.24). Normotensive individuals had a higher standard deviation of RR intervals, a higher coefficient of variation of RR intervals, a higher standard deviation of heart rate, and a higher percentage of successive differences in RR intervals in the time domain. They also had higher values of very low-frequency power, low-frequency (LF) power, and high-frequency (HF) power in the frequency domain. The LF/HF ratio was not significantly different between the two groups. In nonlinear analysis, SD2, a measure of long-term heart rate variability, was higher in normotensive individuals. ConclusionThe Oxford/AstraZeneca COVID-19 vaccine did not have a significant effect on HRV parameters in normotensive and hypertensive adults one year after vaccination. However, changes in HRV parameters were observed between supine and standing positions, suggesting the importance of postural changes in HRV assessment.

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Section: Discussioncontrasting

confidence: 85%

Heart Rate Variability in Normotensive and Hypertensive Adults After a Year of Receiving Oxford/AstraZeneca COVID-19 Vaccine: A Cross-Sectional Observational Study

Sunita¹,

Manjulata²,

Mondal³

et al. 2023

Cureus

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“…Poincaré method. With this popular geometric method [20], the following parameters are determined (Table 2):…”

Section: Nonlinear Methods Of Analysismentioning

confidence: 99%

Heart Rate Variability Analysis of Healthy Individuals and Patients with Ischemia and Arrhythmia

Georgieva-Tsaneva,

Gospodinova

2023

Diagnostics

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This article presents the results of a study of the cardiac activity of patients diagnosed with arrhythmia and ischemic heart disease. The obtained results were compared with the results obtained from a healthy control group. The studies were conducted on long-term cardiac recordings (approximately 24 h) registered by means of Holter monitoring, and the observations were made in the daily activities of the individuals. All processing, analysis and evaluations on the registered signals were performed by means of an established information demonstration cardiology system. The mathematical analysis included linear, non-linear and graphical methods for estimating and analyzing heart rate variability (HRV). Re-examinations were carried out on some of the observed individuals after six months of treatment. The results show an increase in the main time domain parameters of the HRV, such as the SDNN (from 86.36 ms to 95.47 ms), SDANN (from 74.05 ms to 82.14 ms), RMSSD (from 5.1 ms to 6.92 ms), SDNN index (from 52.4 to 58.91) and HRVTi (from 12.8 to 16.83) in patients with ischemia. In patients with arrhythmia, there were increases in the SDNN (from 88.4 ms to 96.44 ms), SDANN (from 79.12 ms to 83.23 ms), RMSSD (from 6.74 ms to 7.31 ms), SDNN index (from 53.22 to 59.46) and HRVTi (from 16.2 to 19.42). An increase in the non-linear parameter α (from 0.83 to 0.85) was found in arrhythmia; and in α (from 0.80 to 0.83), α1 (from 0.88 to 0.91) and α2 (from 0.86 to 0.89) in ischemia. The presented information system can serve as an auxiliary tool in the diagnosis and treatment of cardiovascular diseases.

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“…Low HRV and BRS are generally regarded as indicators of elevated cardiovascular risk 158 and may reflect a reduced capacity to counteract sympathetic activation through vagal mechanisms. 159 However, subjects with significant heart rhythm abnormalities and a higher prevalence of clinical CVD were found to exhibit elevated HRV. Exposure to ambient air pollution has been linked to both decreased and increased HRV.…”

Section: Compendium On Environmental Impacts On Cardiovascular Health...mentioning

confidence: 99%

Impact of Wildfires on Cardiovascular Health

Williams,

Perreault,

Yazbeck

et al. 2024

Circulation Research

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Wildfire smoke (WFS) is a mixture of respirable particulate matter, environmental gases, and other hazardous pollutants that originate from the unplanned burning of arid vegetation during wildfires. The increasing size and frequency of recent wildfires has escalated public and occupational health concerns regarding WFS inhalation, by either individuals living nearby and downstream an active fire or wildland firefighters and other workers that face unavoidable exposure because of their profession. In this review, we first synthesize current evidence from environmental, controlled, and interventional human exposure studies, to highlight positive associations between WFS inhalation and cardiovascular morbidity and mortality. Motivated by these findings, we discuss preventative measures and suggest interventions to mitigate the cardiovascular impact of wildfires. We then review animal and cell exposure studies to call attention on the pathophysiological processes that support the deterioration of cardiovascular tissues and organs in response to WFS inhalation. Acknowledging the challenges of integrating evidence across independent sources, we contextualize laboratory-scale exposure approaches according to the biological processes that they model and offer suggestions for ensuring relevance to the human condition. Noting that wildfires are significant contributors to ambient air pollution, we compare the biological responses triggered by WFS to those of other harmful pollutants. We also review evidence for how WFS inhalation may trigger mechanisms that have been proposed as mediators of adverse cardiovascular effects upon exposure to air pollution. We finally conclude by highlighting research areas that demand further consideration. Overall, we aspire for this work to serve as a catalyst for regulatory initiatives to mitigate the adverse cardiovascular effects of WFS inhalation in the community and alleviate the occupational risk in wildland firefighters.

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The Role of Heart Rate Variability (HRV) in Different Hypertensive Syndromes

Cited by 26 publications

References 129 publications

Heart Rate Variability in Normotensive and Hypertensive Adults After a Year of Receiving Oxford/AstraZeneca COVID-19 Vaccine: A Cross-Sectional Observational Study

Heart Rate Variability in Normotensive and Hypertensive Adults After a Year of Receiving Oxford/AstraZeneca COVID-19 Vaccine: A Cross-Sectional Observational Study

Heart Rate Variability Analysis of Healthy Individuals and Patients with Ischemia and Arrhythmia

Impact of Wildfires on Cardiovascular Health

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