The role of haematological parameters in patients with COVID-19 and influenza virus infection

Kazancıoğlu, Sümeyye; Baştuğ, Aliye; Özbay, Bahadır Orkun; Kemirtlek, Nizamettin; Bodur, Hürrem

doi:10.1017/s095026882000271x

Cited by 46 publications

(54 citation statements)

References 30 publications

(43 reference statements)

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“…Only two studies investigated the NLR levels in COVID-19 compared to In uenza. One found no difference, and the other found that NLR was signi cantly lower in the COVID-19 patients (median of 2.6), as was described in our report 32,44 . In all reports, as in ours, CRP levels at admission were similar across the viruses.…”

Section: Discussionsupporting

confidence: 79%

Prognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection

Prozan¹,

Shusterman²,

Ablin³

et al. 2020

Preprint

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Background: A high Neutrophil to Lymphocyte Ratio (NLR) is considered an unfavorable prognostic factor in various diseases, including COVID-19. The prognostic value of NLR in other respiratory viral infections, such as Influenza, has not hitherto been extensively studied. We aimed to compare the prognostic value of NLR in COVID-19, Influenza and Respiratory Syncytial Virus infection (RSV).Method: A retrospective cohort of COVID-19, Influenza and RSV patients admitted to the Tel Aviv Medical Center from January 2010 to October 2020 was analyzed. Laboratory, demographic, and clinical parameters were collected. Two way analyses of variance (ANOVA) was used to compare the association between NLR values and poor outcomes among the three groups. ROC curve analyses for each virus was applied to test the discrimination ability of NLR. Results: 722 COVID-19, 2213 influenza and 482 RSV patients were included. Above the age of 50, NLR at admission was significantly lower among COVID-19 patients (P<0.001). NLR was associated with poor clinical outcome only in the COVID-19 group. ROC curve analysis was performed; the area under curve of poor outcomes for COVID-19 was 0.643, compared with 0.497 and 0.537 for Influenza and RSV respectively. In the COVID-19 group, multivariate logistic regression identified a high NLR (defined as a value above 4.7) to be a prognostic factor for poor clinical outcome, after adjusting for age, sex and Charlson comorbidity score (odds ratio of 1.6, P=0.005). Conclusions: NLR at admission is lower and has more prognostic value in COVID-19 patients, when compared to Influenza and RSV.

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Section: Discussionsupporting

confidence: 79%

Prognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection

Prozan¹,

Shusterman²,

Ablin³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…A model combining clinical features and inflammatory markers has proven to be useful for predicting the bacterial etiology of community-acquired pneumonia, with a specificity of 96.6% [ 22 , 23 ]. Several biomarkers such as monocyte count, percentage of basophils, and time from symptom onset to hospital admission were significantly different between COVID-19 and influenza, which could help the differential diagnosis [ 24 – 29 ]. These investigations were helpful in the differential diagnosis and elucidated the differing pathogenesis of the 2 diseases.…”

Section: Introductionmentioning

confidence: 99%

Performance of Diagnostic Model for Differentiating Between COVID-19 and Influenza: A 2-Center Retrospective Study

Qiu

et al. 2021

Med Sci Monit

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Background COVID-19 and influenza share many similarities, such as mode of transmission and clinical symptoms. Failure to distinguish the 2 diseases may increase the risk of transmission. A fast and convenient differential diagnosis between COVID-19 and influenza has significant clinical value, especially for low- and middle-income countries with a shortage of nucleic acid detection kits. We aimed to establish a diagnostic model to differentiate COVID-19 and influenza based on clinical data. Material/Methods A total of 493 patients were enrolled in the study, including 282 with COVID-19 and 211 with influenza. All data were collected and reviewed retrospectively. The clinical and laboratory characteristics of all patients were analyzed and compared. We then randomly divided all patients into development sets and validation sets to establish a diagnostic model using multivariate logistic regression analysis. Finally, we validated the diagnostic model using the validation set. Results We preliminarily established a diagnostic model for differentiating COVID-19 from influenza that consisted of 5 variables: age, dry cough, fever, white cell count, and D-dimer. The model showed good performance for differential diagnosis. Conclusions This initial model including clinical features and laboratory indices effectively differentiated COVID-19 from influenza. Patients with a high score were at a high risk of having COVID-19, while patients with a low score were at a high risk of having influenza. This model could help clinicians quickly identify and isolate cases in the absence of nucleic acid tests, especially during the cocirculation of COVID-19 and influenza. Owing to the study’s retrospective nature, further prospective study is needed to validate the accuracy of the model.

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“…Patients with COVID pneumonia had a greater decreased number of white blood cells including neutrophils, compared with patients with influenza pneumonia in previous studies. 9 , 17 , 27 , 30 But even neutropenia associated with the disease or discriminative role for the two viral infections is not clearly detected. 10 , 28 , 29 Therefore, it is not realistic to conclude as suggested by Luo et al 9 using decreased lymphocytes and neutrophils for differentiating COVID‐19 from influenza due to the inconclusive results.…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical and biochemical features of hospitalized COVID‐19 and influenza pneumonia patients

Hattatoğlu

Yıldız

2021

Journal of Medical Virology

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Both severe acute respiratory syndrome coronavirus 2 and influenza viruses cause similar clinical presentations. It is essential to assess severely ill patients presenting with a viral syndrome for diagnostic and prognostic purposes. We aimed to compare clinical and biochemical features between pneumonia patients with coronavirus disease 2019 (COVID‐19) and H1N1. Sixty patients diagnosed with COVID‐19 pneumonia and 61 patients diagnosed with influenza pneumonia were hospitalized between October 2020–January 2021 and October 2017–December 2019, respectively. All the clinical data and laboratory results, chest computed tomography scans, intensive care unit admission, invasive mechanical ventilation, and outcomes were retrospectively evaluated. The median age was 65 (range 32–96) years for patients with a COVID‐19 diagnosis and 58 (range 18–83) years for patients with influenza ( p = 0.002). The comorbidity index was significantly higher in patients with COVID‐19 ( p = 0.010). Diabetes mellitus and hypertension were statistically significantly more common in patients with COVID‐19 ( p = 0.019, p = 0.008, respectively). The distribution of severe disease and mortality was not significantly different among patients with COVID‐19 than influenza patients ( p = 0.096, p = 0.049).). In comparison with inflammation markers; C‐reactive protein (CRP) levels were significantly higher in influenza patients than patients with COVID‐19 ( p = 0.033). The presence of sputum was predictive for influenza (odds ratio [OR] 0.342 [95% confidence interval [CI], 2.1.130–0.899]). CRP and platelet were also predictive for COVID‐19 (OR 4.764 [95% CI, 1.003–1.012] and OR 0.991 [95% CI 0.984–0.998], respectively. We conclude that sputum symptoms by itself are much more detected in influenza patients. Besides that, lower CRP and higher PLT count would be discriminative for COVID‐19.

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The role of haematological parameters in patients with COVID-19 and influenza virus infection

Cited by 46 publications

References 30 publications

Prognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection

Prognostic value of Neutrophil-to-lymphocyte ratio in COVID-19 compared with Influenza and respiratory syncytial virus infection

Performance of Diagnostic Model for Differentiating Between COVID-19 and Influenza: A 2-Center Retrospective Study

Comparison of clinical and biochemical features of hospitalized COVID‐19 and influenza pneumonia patients

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