The role of H3K27me3 methylation in cancer development

Di, Longjiang; Zhu, Wei-Guo

doi:10.1007/s42764-023-00118-0

Cited by 1 publication

(1 citation statement)

References 167 publications

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“…Increasing studies have indicated that H3K27me3 is involved in liver diseases, including NAFLD, liver fibrosis and hepatitis B [ 11 , 12 ]. For example, H3K27me3 in the proximal promoter region of CFTR in the Hcy treated liver of mice, but not H3K27me1 and H3K27me2 [ 13 ]. hyperhomocysteine inhibits cystic fibrosis transmembrane conductance regulator (CFTR) expression through the interaction between H3K27me3 and DNA methylation, thereby activating autophagy and leading to persistent liver injury [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic regulation of H3K27me3 in laying hens with fatty liver hemorrhagic syndrome induced by high-energy and low-protein diets

Cui,

Ru,

Wang

et al. 2024

BMC Genomics

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Background Fatty liver hemorrhagic syndrome (FLHS) in the modern poultry industry is primarily caused by nutrition. Despite encouraging progress on FLHS, the mechanism through which nutrition influences susceptibility to FLHS is still lacking in terms of epigenetics. Results In this study, we analyzed the genome-wide patterns of trimethylated lysine residue 27 of histone H3 (H3K27me3) enrichment by chromatin immunoprecipitation-sequencing (ChIP-seq), and examined its association with transcriptomes in healthy and FLHS hens. The study results indicated that H3K27me3 levels were increased in the FLHS hens on a genome-wide scale. Additionally, H3K27me3 was found to occupy the entire gene and the distant intergenic region, which may function as silencer-like regulatory elements. The analysis of transcription factor (TF) motifs in hypermethylated peaks has demonstrated that 23 TFs are involved in the regulation of liver metabolism and development. Transcriptomic analysis indicated that differentially expressed genes (DEGs) were enriched in fatty acid metabolism, amino acid, and carbohydrate metabolism. The hub gene identified from PPI network is fatty acid synthase (FASN). Combined ChIP-seq and transcriptome analysis revealed that the increased H3K27me3 and down-regulated genes have significant enrichment in the ECM-receptor interaction, tight junction, cell adhesion molecules, adherens junction, and TGF-beta signaling pathways. Conclusions Overall, the trimethylation modification of H3K27 has been shown to have significant regulatory function in FLHS, mediating the expression of crucial genes associated with the ECM-receptor interaction pathway. This highlights the epigenetic mechanisms of H3K27me3 and provides insights into exploring core regulatory targets and nutritional regulation strategies in FLHS.

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