The Role of Gut Mucins in the Etiology of Depression

Rivet-Noor, Courtney; Gaultier, Alban

doi:10.3389/fnbeh.2020.592388

Cited by 8 publications

(5 citation statements)

References 54 publications

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“…The common themes of this review have focused on the microbiome/microbiota or gut metabolome [ 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 ], the microbiota-gut-brain axis, and related factors [ 152 , 162 , 163 , 164 , 165 , 166 , 167 ]. When there is an imbalance in the intestinal bacteria, this can interfere with emotional regulation and contribute to harmful inflammatory processes and mood disorders [ 148 , 151 , 153 , 155 , 157 ].…”

Section: Resultsmentioning

confidence: 99%

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

2021

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Depression is one of the leading causes of disability, and, if left unmanaged, it can increase the risk for suicide. The evidence base on the determinants of depression is fragmented, which makes the interpretation of the results across studies difficult. The objective of this study is to conduct a thorough synthesis of the literature assessing the biological, psychological, and social determinants of depression in order to piece together the puzzle of the key factors that are related to this condition. Titles and abstracts published between 2017 and 2020 were identified in PubMed, as well as Medline, Scopus, and PsycInfo. Key words relating to biological, social, and psychological determinants as well as depression were applied to the databases, and the screening and data charting of the documents took place. We included 470 documents in this literature review. The findings showed that there are a plethora of risk and protective factors (relating to biological, psychological, and social determinants) that are related to depression; these determinants are interlinked and influence depression outcomes through a web of causation. In this paper, we describe and present the vast, fragmented, and complex literature related to this topic. This review may be used to guide practice, public health efforts, policy, and research related to mental health and, specifically, depression.

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Section: Resultsmentioning

confidence: 99%

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

2021

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“…Rivet-Noor [ 43 ] reviewed the evidence about the relationship between disruption of intestinal mucins and depression and addressed that stress can modify the delicate mucus-microbiome balance, initiating dysbiosis and ultimately leading to depression. Moreover, conducted a clinical with patients suffering from major depressive disorder (MDD) investigating pro-inflammatory pathways related to the “likable bowel” hypothesis associated with MDD, defined as an intestinal translocation of bacterial and an abnormal toll-like receptor-mediated immune response initiating a systemic inflammatory state, microglial activation, and neuroinflammation.…”

Section: Discussionmentioning

confidence: 99%

Baccharis dracunculifolia DC Hydroalcoholic Extract Improves Intestinal and Hippocampal Inflammation and Decreases Behavioral Changes of Colitis Mice

França

Ribeiro

Mariano

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The hydroalcoholic extract of B. dracunculifolia (HEBD) and its major compound p-coumaric acid were evaluated against the severity of intestinal inflammation and behavioral changes like depressive and anxious behavior in colitis mice. Colitis was induced in Swiss mice by oral dextran sulfate sodium (DSS) administration for five days. The mice received vehicle (10 ml/kg), HEBD (3, 30, or 300 mg/kg), or p-coumaric acid (15 mg/kg) orally, once a day for twelve days. Behavioral tests were performed on the 11th and 12th days after the beginning of the treatments. Moreover, the colon, cortex, and hippocampus were collected to analyze oxidative and inflammatory parameters. The treatment with HEBD (300 mg/Kg), but not p-coumaric acid, showed decreased disease activity index (DAI) values compared to the vehicle group and partially preserved the villi architecture and mucin levels. Furthermore, the HEBD increased the antioxidant defenses in the colon and hippocampus and reduced the myeloperoxidase activity and IL-6 levels in the colon from colitis mice. Colitis mice treated with HEBD did not show depressive-like behavior in the tail suspension test. HEBD reduced colon inflammation, while it maintains antioxidant defenses and mucin levels in this tissue. It may reduce neuropsychiatric comorbidities associated with colitis through its antioxidant effects.

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“…41–43 In addition, SNPs in O-glycosylation have also been identified in populations with treatment resistant depression. 43,44 Together, these data support our results suggesting that mucin 13 is an important driver of microbiome dysbiosis and depressive-like behaviors in mice.…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, single nucleotide polymorphisms (SNPs) in mucin 13 have been identified in GWAS studies of depressed populations. [41][42][43] In addition, SNPs in O-glycosylation have also been identified in populations with treatment resistant depression. 43,44 Together, these data support our results suggesting that mucin 13 is an important driver of microbiome dysbiosis and depressive-like behaviors in mice.…”

Section: Discussionmentioning

confidence: 99%

Stress-Induced Mucin 13 Reductions Drive Intestinal Microbiome Shifts and Despair Behaviors

Rivet-Noor

Merchak

Render

et al. 2022

Preprint

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Depression is a common mental health condition with a large social and economic impact. While depression etiology is multifactorial, chronic stress is a well-accepted contributor to disease onset. In addition, depression is associated with altered gut microbial signatures that can be replicated in animal models. While targeted restoration of the microbiome has been shown to reduce depressive-like behaviors in mice, the complexity and diversity of the human microbiome has complicated therapeutic intervention in patients. To circumvent these limitations, there is a critical need for identifying pathways responsible for microbiome dysbiosis. Here, for the first time, we identify the changes in host physiology that induce microbiome dysbiosis. Specifically, we show that a component of mucosal layer, the transmembrane protein mucin 13, can regulate microbiome composition. Using a model of chronic stress to induce behavioral and microbial changes in mice, we show a significant reduction in mucin 13 expression across the intestines that occurs independently of the microbiome. Furthermore, deleting Muc13 leads to gut dysbiosis, and baseline behavioral changes normally observed after stress exposure. Together, these results validate the hypothesis that mucosal layer disruption is an initiating event in stress-induced dysbiosis and offer mucin 13 as a potential new therapeutic target for microbiome dysbiosis in stress-induced depression. For the first time, our data provide an upstream and conserved target for treating microbiome dysbiosis, a result with sweeping implications for diseases presenting with microbial alterations.

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The Role of Gut Mucins in the Etiology of Depression

Cited by 8 publications

References 54 publications

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

Baccharis dracunculifolia DC Hydroalcoholic Extract Improves Intestinal and Hippocampal Inflammation and Decreases Behavioral Changes of Colitis Mice

Stress-Induced Mucin 13 Reductions Drive Intestinal Microbiome Shifts and Despair Behaviors

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