The Role of Gut Microbiota and Genetic Susceptibility in the Pathogenesis of Pancreatitis

Xu, Fumin; Yang, Chunmei; Tang, Mingcheng; Wang, Ming; Zhenhao, CHENG; Chen, Dongfeng; Chen, Xiao; Liu, Kai Jun

doi:10.5009/gnl210362

Cited by 9 publications

(8 citation statements)

References 99 publications

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“…Studies have shown that mutation of the transmembrane conductance regulator of cystic brosis (CFTR) and tumour necrosis factor-promoting polymorphism may contribute to the onset of HTG-AP. More research is necessary to examine the speci c role of genetic factors in HTG-AP development [32]. HTG-AP can cause and worsen AP through various pathways, and it has been demonstrated that HTG-AP is generally associated with higher clinical severity and complication rates [9,33].…”

Section: Discussionmentioning

confidence: 99%

Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis

Yi,

Zeng,

Lin

et al. 2023

Preprint

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Background The prevalence of hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) is increasing due to improvements in living standards and dietary changes. However, at present, there is no clinical multifactor scoring system specific to HTG-AP. This study aimed to screen the predictors of hypertriglyceridemia severe acute pancreatitis (HTG-SAP) and combined several indicators to establish and verify a visual model for the early prediction of HTG-SAP. Methods The clinical data of 266 patients with HTG-SAP were analysed. Patients were classified into severe (n = 42) and non-severe (n = 224) groups according to the Atlanta classification criteria. Several statistical analyses, including one-way analysis, least absolute shrinkage with selection operator (LASSO) regression model and binary logistic regression analysis were used to evaluate the data. Result The univariate analysis found that several factors showed no statistically significant differences, including number of episodes of pancreatitis, abdominal pain score and several blood diagnostic markers, such as lactate dehydrogenase (LDH), serum calcium (Ca2+), C-reactive protein (CRP) and the incidence of pleural effusion, between the two groups (P < 0.000). LASSO regression analysis identified six candidate predictors: CRP, LDH, Ca2+, procalcitonin (PCT), ascites and Balthazar computed tomography (CT) grade. Binary logistic regression multivariate analysis showed that CRP, LDH, Ca2+, and ascites were independent predictors of HTG-SAP. The area under the curve (AUC) was 0.886, 0.893, 0.872, and 0.850, respectively. The AUC of the newly established HTG-SAP model was 0.960 (95% confidence interval: 0.936–0.983), which was higher than that of the bedside index for severity in acute pancreatitis, modified CT severity index, Ranson score and Japanese severity score (JSS) CT grade (AUC: 0.794, 0.796, 0.894 and 0.764, respectively). The differences were statistically significant (P < 0.01), except for the JSS prognostic indicators (P = 0.130). The Hosmer–Lemeshow test showed that the predictive results of the model were highly consistent with the actual situation (P > 0.05). The decision curve analysis plot suggested that clinical intervention can benefit patients when the model predicts that they are at risk for developing HTG-SAP. Conclusions CRP, LDH, Ca2+ and ascites are independent predictors of HTG-SAP. The prediction model constructed based on these indicators has a high accuracy, sensitivity, consistency and practicability in predicting HTG-SAP.

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Section: Discussionmentioning

confidence: 99%

Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis

Yi,

Zeng,

Lin

et al. 2023

Preprint

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“…The knockout of the receptor GPR43 increased susceptibility to dextran-sodium-sulfate-induced colitis in mice by increasing chemotaxis of neutrophils and inflammatory gene expression [ 4 ]. SCFAs are considered to be vital components in maintaining the integrity of the intestinal barrier [ 23 ]. Studies have shown that SCFAs can promote the intestinal epithelial thigh junction protein synthesis, inhibit intestinal permeability, and even enhance the intestinal mucosal immune barrier function [ 24 ].…”

Section: Gut Microbiota Profile In Pancreatitismentioning

confidence: 99%

Exploring the Microbial Landscape: Gut Dysbiosis and Therapeutic Strategies in Pancreatitis—A Narrative Review

Lupu,

Bratu,

Trandafir

et al. 2024

Biomedicines

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The gut microbiota is emerging as an important contributor to the homeostasis of the human body through its involvement in nutrition and metabolism, protection against pathogens, and the development and modulation of the immune system. It has therefore become an important research topic in recent decades. Although the association between intestinal dysbiosis and numerous digestive pathologies has been thoroughly researched, its involvement in pancreatic diseases constitutes a novelty in the specialized literature. In recent years, growing evidence has pointed to the critical involvement of the pancreas in regulating the intestinal microbiota, as well as the impact of the intestinal microbiota on pancreatic physiology, which implies the existence of a bidirectional connection known as the “gut–pancreas axis”. It is theorized that any change at either of these levels triggers a response in the other component, hence leading to the evolution of pancreatitis. However, there are not enough data to determine whether gut dysbiosis is an underlying cause or a result of pancreatitis; therefore, more research is needed in this area. The purpose of this narrative review is to highlight the role of gut dysbiosis in the pathogenesis of acute and chronic pancreatitis, its evolution, and the prospect of employing the microbiota as a therapeutic intervention for pancreatitis.

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“…Increased intestinal permeability has been demonstrated in a significant percentage of patients with AP [120], with circulating bacterial DNA representative of gut bacteria in 68.8% of patients with AP. Zhang and colleagues showed that patients with AP had more Proteobacteria and Bacteroidetes and fewer Actinobacteria and Firmicutes in their feces, compared with normal controls [121]. The clinical significance of gut dysbiosis is poorly understood, but these patients have been found to have worse outcomes .…”

Section: Gut Microbiome Impact In Apmentioning

confidence: 99%

Advances in Nutritional Therapy of Acute Pancreatitis

Chávez-Tostado¹,

Chávez-Tostado²,

González-Ojeda³

et al. 2023

Multidisciplinary Management of Acute and Chronic Pancreatitis

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Acute pancreatitis (AP) is a frequent abdominal acute inflammatory disorder and the leading cause of hospital admissions in gastrointestinal units. Clinical manifestations of AP vary from a mild edematous form to severe fulminant pancreatitis with major devastating complications. To date, experimental therapeutic agents remain scarce for the treatment of this disease. Nutritional therapy with appropriate nutrient supplementation is key to limiting the acute inflammation and preventing and managing complications associated with AP. This chapter focuses on novel therapeutic agents for nutritional intervention including enteral versus parenteral nutrition strategies, and nutritional supplements such as probiotics, glutamine, omega-3 fatty acids, and vitamins in the treatment of AP.

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The Role of Gut Microbiota and Genetic Susceptibility in the Pathogenesis of Pancreatitis

Cited by 9 publications

References 99 publications

Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis

Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis

Exploring the Microbial Landscape: Gut Dysbiosis and Therapeutic Strategies in Pancreatitis—A Narrative Review

Advances in Nutritional Therapy of Acute Pancreatitis

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