The role of gut microbiota in cerebrovascular disease and related dementia

Cuartero, María Isabel; García‐Culebras, Alicia; Nieto‐Vaquero, Carmen; Fraga, Enrique; Torres‐López, Cristina; Pradillo, Jesús M.; Lizasoaín, Ignacio; Moro, Marı́a A.

doi:10.1111/bph.16167

Cited by 5 publications

(3 citation statements)

References 157 publications

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“…As metagenomics research progresses, our comprehension of the gut microbiota has grown, elucidating their increasingly evident connection with various diseases. For instance, gut microbes influence physiology by partially breaking down dietary components and substances produced by the host, leading to the production of bioactive compounds, including toxins ( 47 ). Gut microorganisms have a central role in regulating the overall purine balance and serum uric acid (UA) levels in the host ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of gut microbiome in patients with pediatric solid tumor

Du,

Cui,

Fan

et al. 2024

Front. Pediatr.

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BackgroundPediatric solid tumors are a common malignant disease in children, and more and more studies have proved that there is an inseparable relationship between adult tumors and intestinal microbiome, but the changes in the intestinal microbiota of pediatric solid tumor (PST) patients have been scarcely examined. This study aims to examine the differences in the intestinal microbiota features between patients diagnosed with PST and healthy controls (HCs).MethodsTo elucidate the unique characteristics of the gut microbiota in pediatric patients with solid tumors, we recruited 23 PST patients and 20 HCs. A total of 43 stool samples were gathered, and then 16S rRNA sequencing was performed.ResultsWe noticed a noticeable pattern of elevated diversity in the gut microbiota within the PST groups. The differences in microbial communities among two groups were remarkable, regarding the analysis at the class level, the abundance of Bacilli was markedly increased in PST patients compared to HCs (P < 0.05), regarding the analysis at the genus level, The presence of Enterococcus was significantly higher in PST cases compared to HCs (P < 0.01), while Lachnospiraceae unclassified, Lachnospira, Haemophilus and Colidextribacter in PST cases, the abundance was significantly reduced. (P < 0.05), 6 genera, including Bacilli, Lactobacillales, Enterococcaceae and Morganella, showed a significant enrichment compared to healthy controls, while 10 genera, including Bilophila, Colidextribacter, Pasteurellales, Haemophilus, Lachnospiraceae unclassified, Lachnospira and Fusobacteriales, were significant reduction in the PST groups.ConclusionOur research conducted the characterization analysis of the gut microbiota in PST patients for the first time. More importantly, there are some notable differences in the gut microbiota between PST patients and healthy controls, which we believe is an interesting finding.

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Section: Discussionmentioning

confidence: 99%

Characteristics of gut microbiome in patients with pediatric solid tumor

Du,

Cui,

Fan

et al. 2024

Front. Pediatr.

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“…In addition, some studies have found differences in GM composition between healthy people and people with cognitive impairment or different types of cognitive impairment, attempting to use this information to make a diagnosis of the disease ( Guo et al, 2021 ; Hung et al, 2022 ). Therefore, clarifying the influence of different flora on dementia is essential for ascertaining new therapeutic targets for dementia and diagnosing dementia using microbial profiles ( Liu et al, 2019 ; Guo et al, 2021 ; Cuartero et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Causal relationship between gut microflora and dementia: a Mendelian randomization study

Fu,

Qin,

Xiao

et al. 2024

Front. Microbiol.

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BackgroundNumerous pertinent investigations have demonstrated a correlation between gut microflora (GM) and the occurrence of dementia. However, a causal connection between GM and dementia and its subtypes has not yet been clarified.ObjectiveTo explore the causal association between GM and dementia, including its subtypes, a two-sample Mendelian randomization (TSMR) analysis was used.MethodsOur data comes from the Genome-Wide Association Study (GWAS). The principal approach employed for the Mendelian randomization study was the inverse-variance weighted method, supplemented by four methods: MR-Egger, weighted median, simple mode, and weighted mode. This was followed by Cochrane’s Q test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out as sensitivity analysis validation.ResultsTwenty-one GMs associated with any dementia, Alzheimer’s disease, vascular dementia, Lewy body dementia, Parkinson’s disease, and dementia under other disease classifications were derived from the analysis, and 21 passed sensitivity tests.ConclusionWe confirmed the causal relationship between GM and dementia and its subtypes, derived specific flora associated with increased or decreased risk of dementia, and provided new ideas for preventive, diagnostic, and therapeutic interventions for dementia mediated by gut microbiota.

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“…In part by interacting with the immune system, increasing evidence suggests that commensal microbiota have a major role both in homeostasis and in pathological contexts including cerebrovascular diseases. In this vein, Cuartero et al (2024) underscore the intricate interplay between microbiota and metabolism, immunity, brain development and function. Specifically, the possible participation of microbiota-derived products in post-stroke cognitive impairment and dementia is discussed, including potential therapeutic opportunities ranging from probiotics and prebiotics, antibiotics, and faecal microbiota transplantation.…”

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confidence: 99%