The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer

Sui, Yue; Wu, Jianming; Chen, Jianping

doi:10.3389/fcell.2021.631552

Cited by 71 publications

(86 citation statements)

References 144 publications

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“…As well, dysbiosis of intestinal microbiota also affects the regulation of bacterial metabolites ( 55 ). Short-chain fatty acids (SCFAs) are produced by symbiotic bacteria that digest dietary fiber in the intestine, including acetate, propionate, and butyrate, etc.…”

Section: The Risk Factors With the Occurrence Of Ucmentioning

confidence: 99%

The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

et al. 2021

Front. Med.

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Ulcerative Colitis (UC) is a chronic inflammatory bowel disease. The prolonged course of UC and the lack of effective treatment management make it difficult to cure, affecting the health and life safety of patients. Although UC has received more attention, the etiology and pathogenesis of UC are still unclear. Therefore, it is urgent to establish an updated and comprehensive understanding of UC and explore effective treatment strategies. Notably, sufficient evidence shows that the intestinal microbiota plays an important role in the pathogenesis of UC, and the treating method aimed at improving the balance of the intestinal microbiota exhibits a therapeutic potential for UC. This article reviews the relationship between the genetic, immunological and microbial risk factors with UC. At the same time, the UC animal models related to intestinal microbiota dysbiosis induced by chemical drugs were evaluated. Finally, the potential value of the therapeutic strategies for restoring intestinal microbial homeostasis and treating UC were also investigated. Comprehensively, this study may help to carry out preclinical research, treatment theory and methods, and health management strategy of UC, and provide some theoretical basis for TCM in the treatment of UC.

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Section: The Risk Factors With the Occurrence Of Ucmentioning

confidence: 99%

The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

et al. 2021

Front. Med.

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“…The gut microbiota is a major determinant of the circulating levels of estrogens through different mechanisms. Firstly, they produce and secrete the enzyme β-glucuronidase, which deconjugates estrogen and increases the bioavailability of its active form [186]. Furthermore, some microorganisms break down indigestible dietary polyphenols to synthesize estrogen-like compounds or estrogen mimics that exhibit varied estrogenic potency [187].…”

Section: Estrobolomementioning

confidence: 99%

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

et al. 2022

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The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning of the organism, affecting the health and disease status of the individuals. There is continuous and bidirectional communication between gut microbiota and the host, conforming to a unique entity known as “holobiont”. Among these crosstalk mechanisms, the gut microbiota synthesizes a broad spectrum of bioactive compounds or metabolites which exert pleiotropic effects on the human organism. Many of these microbial metabolites can cross the blood–brain barrier (BBB) or have significant effects on the brain, playing a key role in the so-called microbiota-gut-brain axis. An altered Microbiota-Gut-Brain (MGB) axis is a major characteristic of many neuropsychiatric disorders, including major depressive disorder (MDD). Significative differences between gut eubiosis and dysbiosis in mental disorders like MDD with their different metabolite composition and concentrations are being discussed. In the present review, the main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology. Conclusions from promising translational approaches related to microbial metabolome will be addressed in more depth to discuss their possible clinical value in the management of MDD patients.

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“…Therefore, an estrobolome enriched in b-glucuronidase enzymes that promote estrogen metabolism deconjugation reactions may result in greater absorption of free estrogens that may cause a greater risk of hormone-dependent cancers and other diseases (Fig. 6) [10,22,77,78,[81][82][83]. Notably, one of the prominent roles of the human microbiome in the regulation of endogenous estrogens defines the most important risk factor in breast cancer development especially in postmenopausal women [78].…”

Section: Microbiome-gut-skin Axis and Influence On Skin Health (Estro...mentioning

confidence: 99%

Estrogen Action and Gut Microbiome Metabolism in Dermal Health

Lephart

Naftolin²

2022

Dermatol Ther (Heidelb)

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Emerging scientific advances in microbial research linking estrogens and the gut-skin microbiome in reference to dermal health are featured in this narrative review of journal reports and reviews from January 2018 through February 2022. Background information on advances in microbial research along with defining the microbiota and microbiome is presented in brief. The development of and factors that influence the gut microbiome in health and disease as well as the intrinsic and extrinsic factors influencing the skin microbiome and skin aging are summarized. New information on the development and changes of organ microbiomes have exposed similarities between skin and gut structure/function, microbial components/diversity/taxonomy and how they impact the immune response for combating disease and enhancing wellness. Estrogens promote health and support homeostasis in general and directly impact dermal health. Moreover, the gut, based upon the level of the microbial enzyme b-glucuronidase, which regulates estrogen's enterohepatic recirculation, constitutes a gut-skin microbial axis. This axis revolves around the systemically available estrogen to support immune function, counteract inflammation and oxidative stress, and decrease the risk of hormone-dependent skin cancers. These data support the direct effect of estrogens on skin health and the interaction of diet on dermal health via effects on the gut microflora. Finally, the potential for bioactive botanicals containing phytoestrogens or selective estrogen receptor modulators (SERMs) to evade the effects of gut b-glucuronidase expressing flora is proposed that may have a positive impact on skin.

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The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer

Cited by 71 publications

References 144 publications

The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

Estrogen Action and Gut Microbiome Metabolism in Dermal Health

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