The role of gut-brain axis in SARA-CoV-2 neuroinvasion: Culprit or innocent bystander?

Shi, Yan; Li, Zhenyu; Yang, Chun; Liu, Cunming

doi:10.1016/j.bbi.2021.01.024

Cited by 15 publications

(13 citation statements)

References 11 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it is the evidence that the SARS-CoV-2 can cause intestinal dysfunction (e.g. diarrhea, nausea, vomiting and abdominal pain), microbial imbalances in gut microbiota and related immune disorders ( Shi et al, 2021 ; Jiali et al, 2021 ). Reinforcing all these evidences, there were found virus particles in fecal samples also up to 5 weeks after passed the infection (H. Li et al, 2020 ; Yongjian et al, 2020 ).…”

Section: Arrival and Affectation Of The Sars-cov-2 In Brainmentioning

confidence: 99%

Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience

Sarubbo

Vidal-Balle

et al. 2022

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

Section: Arrival and Affectation Of The Sars-cov-2 In Brainmentioning

confidence: 99%

Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience

Sarubbo

Vidal-Balle

et al. 2022

Brain, Behavior, & Immunity - Health

View full text Add to dashboard Cite

“…It can invade peripheral chemoreceptors and cranial nerves and reach the brain stem ( Li, Bai & Hashikawa, 2020 ). SARS-CoV-2 can also likely enter CNS through gut-brain axis via the enteric nerves ( Esposito et al, 2020 ; Shi et al, 2021 ). In the hematogenous spread, the virus disseminates the circulation and may breach the blood-brain barrier or blood-CSF barrier to enter the brain or through circumventricular organs that lack blood brain barrier (BBB) ( Pezzini & Padovani, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Role of neuroinflammation mediated potential alterations in adult neurogenesis as a factor for neuropsychiatric symptoms in Post-Acute COVID-19 syndrome—A narrative review

Jayakumar

Saraswathi²,

Alarifi

et al. 2022

PeerJ

View full text Add to dashboard Cite

Persistence of symptoms beyond the initial 3 to 4 weeks after infection is defined as post-acute COVID-19 syndrome (PACS). A wide range of neuropsychiatric symptoms like anxiety, depression, post-traumatic stress disorder, sleep disorders and cognitive disturbances have been observed in PACS. The review was conducted based on PRISMA-S guidelines for literature search strategy for systematic reviews. A cytokine storm in COVID-19 may cause a breach in the blood brain barrier leading to cytokine and SARS-CoV-2 entry into the brain. This triggers an immune response in the brain by activating microglia, astrocytes, and other immune cells leading to neuroinflammation. Various inflammatory biomarkers like inflammatory cytokines, chemokines, acute phase proteins and adhesion molecules have been implicated in psychiatric disorders and play a major role in the precipitation of neuropsychiatric symptoms. Impaired adult neurogenesis has been linked with a variety of disorders like depression, anxiety, cognitive decline, and dementia. Persistence of neuroinflammation was observed in COVID-19 survivors 3 months after recovery. Chronic neuroinflammation alters adult neurogenesis with pro-inflammatory cytokines supressing anti-inflammatory cytokines and chemokines favouring adult neurogenesis. Based on the prevalence of neuropsychiatric symptoms/disorders in PACS, there is more possibility for a potential impairment in adult neurogenesis in COVID-19 survivors. This narrative review aims to discuss the various neuroinflammatory processes during PACS and its effect on adult neurogenesis.

show abstract

“…In addition, gastrointestinal infection poses another threat to the nervous system, as it may increase the transport of aberrant proteins like α-synuclein which are associated with neurodegenerative diseases [ 33 ]. More importantly, nerve injury leads to abnormal intestinal blood flow and intestinal dysmotility, which could further promote bacterial components and metabolites' entry into the blood and brain parenchyma, aggravating brain damage [ 34 ]. By the way, the therapeutic potential of multiple drugs used for other diseases leads to the off-label use for COVID-19, such as corticosteroids, antiretroviral drugs (remdesivir, lopinavir-ritonavir, and darunavir), biological treatments (tocilizumab), and antibiotics (azithromycin), but some of which have been shown to induce neurologic and psychiatric symptoms.…”

Section: Neurological Involvement Of Covid-19: From Neuroinvasion To ...mentioning

confidence: 99%

The Impact of COVID-19 and Vaccine on the Human Nervous System

et al. 2022

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Due to its severe impact, multiple COVID-19 vaccines are being developed, approved, and manufactured rapidly. However, some serious adverse events (AEs) were reported after the application of them, significantly increasing concerns about the safety and efficacy of the vaccines and doubts about the necessity of vaccination. Particularly, previous vaccination campaigns have shown us that partial vaccination can induce neurologic AEs. Herein, we discussed in depth the involvement of the nervous system during SARS-CoV-2 infection or after vaccination. On the one hand, COVID-19 could pose an enormous threat to human neurological health through direct infection and indirect neurotoxicity effects. On the other hand, our review indicated that only a few serious neurological AEs following vaccination occurred and among which headache was the most common. Moreover, some neurological AEs do not seem to be related to vaccination. Of course, the causal relationships between several vaccines and AEs are considered plausible and, it is not doubtful that these AEs should be taken seriously by clinicians in assessing the potential risks and benefits of vaccinations in special populations. Nevertheless, in the case of the rapid spread of COVID-19, the potential side effects of vaccination on nervous system should be compared with adverse COVID-19 outcomes rather than being considered alone. Thus, it is obviously a wise option to be vaccinated instead of suffering from serious adverse symptoms of virus infection.

show abstract

The role of gut-brain axis in SARA-CoV-2 neuroinvasion: Culprit or innocent bystander?

Cited by 15 publications

References 11 publications

Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience

Neurological consequences of COVID-19 and brain related pathogenic mechanisms: A new challenge for neuroscience

Role of neuroinflammation mediated potential alterations in adult neurogenesis as a factor for neuropsychiatric symptoms in Post-Acute COVID-19 syndrome—A narrative review

The Impact of COVID-19 and Vaccine on the Human Nervous System

Contact Info

Product

Resources

About