The Role of Growth Factors in Cartilage Repair

Fortier, Lisa A.; Barker, Joseph U.; Strauss, Eric J.; McCarrel, Taralyn M.; Cole, Brian J.

doi:10.1007/s11999-011-1857-3

Cited by 540 publications

(474 citation statements)

References 85 publications

(96 reference statements)

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“…The rationale for the use of PRP was that a great amount of GFs are released from the activated platelets [29]. Working synergistically, these biologically active proteins stimulate the proliferation and differentiation of fibroblasts, osteoblasts, chondrocytes, and mesenchymal stem cells [30].…”

Section: Resultsmentioning

confidence: 99%

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Al-Delayme

Alnuamy

Hamid

et al. 2016

J. Maxillofac. Oral Surg.

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Objective The objective of this study was to determine average improvement during the rest and active mouth opening after ultrasound guided platelets rich plasma injection in the tempromandibular superior joint space for the patients complaining from non-reducing disk displacement. Patients and Methods Thirty-four patients with non-reducing disk displacement underwent guided ultrasound injection of platelet rich plasma to the upper joint space. The extent of maximal mouth opening, chewing efficiency, sound intensity of the TMJ, and tenderness of the TMJ and the masticatory muscles at rest, motion and mastication were thoroughly assessed at the beginning of the study and scheduled for next follow-up at 1st, 3rd, and 6th months. Results Injection with platelets rich plasma was significantly more effective in improvements of the extent of maximal mouth opening, statistics result demonstrated a significant reduction in the VAS values of pain at rest, motion and mastication compared to the baseline VAS values. Conclusion PRP injection to the upper temporomandibular joint space provided improvement in signs and symptoms of patient with non-reducing disk displacement of the temporomandibular joint.

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Section: Resultsmentioning

confidence: 99%

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Al-Delayme

Alnuamy

Hamid

et al. 2016

J. Maxillofac. Oral Surg.

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“…immunoglobulin G and immunoglobulin A) and lysozyme. 8,32 Apoptosis is a distinct form of cell death controlled by an internally encoded suicide programme that includes independent extrinsic and intrinsic pathways. Amikacin, which is not metabolised and remains in hair cells for months, causes the formation of reactive oxygen species, leading to apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation and lysozyme may trigger apoptosis in the rather sensitive cells of the organ of Corti. 8 The decreased therapeutic and protective effects of autologous serum in the organ of Corti compared to the spiral limbus and ganglion cells may be explained by lysozyme activity. Autologous serum lacking lysozyme, which has a destructive effect on cells, may improve the healing and protective effects of autologous serum.…”

Section: Figmentioning

confidence: 99%

“…Growth factors are biologically active polypeptides produced by the body that can stimulate cell division, growth and differentiation. 8 In addition, healing factors such as nerve growth factor, epidermal growth factor, transforming growth factor β, platelet-derived growth factors and insulin-like growth factor-1 are present in both diluted and undiluted serum. 9 Nerve growth factor is the bestknown neurotrophic factor; it is responsible for the growth and survival of developing neurons, and the maintenance of mature neurons.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity

et al. 2017

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Objective: Possible therapeutic and protective benefits of intratympanic autologous serum application in amikacininduced ototoxicity were investigated.Methods: Twenty-four guinea pigs were separated equally into two groups: therapeutic (group A) and protective (group B). Transient evoked otoacoustic emissions were recorded before and after autologous serum application. Apoptotic cells were identified in the organ of Corti, spiral limbus and spiral ganglion by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling ('TUNEL') method.Results: Transient evoked otoacoustic emission responses at 1, 1.4 and 2.8 kHz improved without significance after autologous serum application in group A ( p > 0.05). A significantly protective effect of autologous serum was determined at 4 kHz in group B ( p < 0.05). There were significantly fewer apoptotic cells at the spiral limbus in the therapeutic and protective groups compared to the control group ( p < 0.05).Conclusion: Autologous serum may offer protection against ototoxicity-induced hearing loss, but it cannot restore hearing. Immunohistochemically, autologous serum significantly decreases activation of the intrinsic pathway of pro-apoptotic signalling in mesenchymal cells compared to neurons and neurosensory cells.

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“…Platelets contain numerous growth factors and cytokines that play an essential role in tissue healing, such as transforming growth factor, vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor [89].…”

Section: Biologic Augmentationmentioning

confidence: 99%

Osteochondral lesions of the talus in the athlete: up to date review

Shimozono

Yasui

Ross

et al. 2017

Curr Rev Musculoskelet Med

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Purpose of review Osteochondral lesions of the talus (OLT) are common injuries in athletes. The purpose of this study is to comprehensively review the clinical results and return to sport capacity in athletes following treatment for OLT. Recent findings Reparative procedures, such as bone marrow stimulation, and replacement procedures, such as autologous osteochondral transplantation, provide good clinical outcomes in short-and mid-term follow-up in the athlete. Recently, biological augmentation and scaffold-based therapies have been shown to improve clinical and radiological outcomes in OLT in both the general population and athletes. Summary Most studies are of a low level of evidence. Studies analyzing the return to sport capability in athletes are further lacking. High-level evidence and well-designed clinical trials are required to establish the most effective treatment protocol.

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The Role of Growth Factors in Cartilage Repair

Abstract: The application of growth factors in the treatment of local cartilage defects as well as osteoarthritis appears promising; however, further research is needed at both the basic science and clinical levels before routine application.

Cited by 540 publications

References 85 publications

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

The Efficacy of Platelets Rich Plasma Injection in the Superior Joint Space of the Tempromandibular Joint Guided by Ultra Sound in Patients with Non-reducing Disk Displacement

Therapeutic and protective effects of autologous serum in amikacin-induced ototoxicity

Osteochondral lesions of the talus in the athlete: up to date review

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