The role of growth factors in proliferative diabetic retinopathy

Forrester, John V.; Shafiee, Afshin; Schröder, Susanne; Knott, Rachel M.; McIntosh, L. C.

doi:10.1038/eye.1993.61

Cited by 26 publications

(23 citation statements)

References 81 publications

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“…A role for leukocytes in the pathogenesis of proliferative diabetic retinopathy has been suggested [11,12]. Under this scheme, adhesion occurs between mutually "activated" leukocytes and endothelium particularly in the small vessels and causes capillary obstruction and occlusion.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, leukocyte activation and adhesion to the endothelium have been considered as a cause of capillary occulsion in diabetic retinopathy [11,12]. Leukocytes adhere to the endothelium initially via specific cell surface adhesion molecules [selectins] [13], followed by further adhesion via integrin-cell adhesion molecule interactions (ICAM-1 lymphocyte function associated antigen-1 LFA-1) and vascular cell adhesion molecule (VCAM)-1/very late activation antigen (VLA-4).…”

mentioning

confidence: 99%

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Soluble leucocyte adhesion molecules in diabetic retinopathy stimulate retinal capillary endothelial cell migration

et al. 1997

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Soluble leucocyte adhesion molecules in diabetic retinopathy stimulate retinal capillary endothelial cell migration

et al. 1997

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“…Changes in retinal basement membrane extra-cellular matrix proteins, 5 haemodynamic changes, 6 growth factors 7 and cytokines 8 have been implicated.…”

Section: Pathogenesis Of Diabetic Maculopathymentioning

confidence: 99%

The role of serum lipids in exudative diabetic maculopathy: is there a place for lipid lowering therapy?

Chowdhury

Hopkins

Dodson

et al. 2002

Eye

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The treatment for diabetic maculopathy is laser photocoagulation of the pigment epithelium. With the advent of systemic lipid lowering therapy over the last decade, there may be potential for medical therapy also. There is some anecdotal evidence of the effect of lipid lowering agents (particularly statins) in reducing exudate, and a number of studies have shown that lipid lowering therapy may reduce macular exudates, but numbers in these trials are small. A randomised controlled trial is now required to investigate whether the use of systemic lipid lowering therapy is of benefit in patients with exudative maculopathy, even in the absence of dyslipidaemia.

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“…Identified local retinal angiogenic growth factors are vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF1), and PDGF, with growth factors derived from ischaemic retinal tissue being more important in the causation of proliferative diabetic retinopathy than pituitary-derived growth factors. 42 A natural inhibitor of the action of growth hormone and IGF1 is somatostatin which could have therepeutic potential. Somatostatin is produced by tissues of the neuroendocrine and gastrointestinal systems and has broad inhibitory actions which also include action Octreotide is a somatostatin analogue that has a halflife of 90 min and an 8-h duration of action and is administered by subcutaneous injection.…”

Section: Endocrine and Paracrine Growth Factorsmentioning

confidence: 99%