The Role of Graphene Oxide Nanocarriers in Treating Gliomas

Wang, Bin; Guo, Hanfei; Xu, Haidong; Chen, Yong; Zhao, Gang; Yu, Haojun

doi:10.3389/fonc.2022.736177

Cited by 11 publications

(13 citation statements)

References 160 publications

(120 reference statements)

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“…One of them is GO's effectiveness and safety which need further research. Among the reasons for the poor effectiveness of GO is its tendency to aggregate under physiological conditions [235,236]. The lack of enough stability in the biological medium can hinder cancer photothermal therapy using GO-based materials.…”

Section: Discussionmentioning

confidence: 99%

“…Surface modifications alter GO's physical and chemical properties and biocompatibility and, thus, can improve the drug carrier and photothermal efficiency. Covalent modifications of GO often require multistep chemical reactions, which may affect the activity of biomolecules, unlike noncovalent modification, which is a simpler process [235,237]. Various polymers have been used for the functionalisation of GO and have been shown to improve the colloidal stability, cytotoxicity and size distribution, as well as biocompatibility and cellular uptake [238].…”

Section: Discussionmentioning

confidence: 99%

“…The current GO nanocarriers load drugs mainly by noncovalent interactions, which makes the GO-drugs complex unstable [240]. Additionally, GO could passively accumulate in cancer tissue due to the EPR effect [235]. More attention has to be paid to active targeting, which could improve the clinical application of GO.…”

Section: Discussionmentioning

confidence: 99%

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Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases per annum, whereas the lack of effective therapies highlights the need for novel therapeutic approaches. Conventional treatment methods, such as surgery, chemotherapy and radiotherapy, are widely applied in oncology practice. Their therapeutic success is little, and therefore, the search for novel technologies is ongoing. Many efforts have focused recently on the development of safe and efficient cancer nanomedicines. Nanoparticles are among them. They are uniquewith their properties on a nanoscale and hold the potential to exploit intrinsic metabolic differences between cancer and healthy cells. This feature allows them to induce high levels of toxicity in cancer cells with little damage to the surrounding healthy tissues. Graphene oxide is a promising 2D material found to play an important role in cancer treatments through several strategies: direct killing and chemosensitization, drug and gene delivery, and phototherapy. Several new treatment approaches based on nanoparticles, particularly graphene oxide, are currently under research in clinical trials, and some have already been approved. Here, we provide an update on the recent advances in nanomaterials-based CRC-targeted therapy, with special attention to graphene oxide nanomaterials. We summarise the epidemiology, carcinogenesis, stages of the CRCs, and current nanomaterials-based therapeutic approaches for its treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Krasteva

Georgieva

2022

Pharmaceutics

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“…Inorganic nanoparticles have drawn much attention for drug delivery to specific sites since they have a high specific surface area and a surface that is easily chemically modified [ 176 ], providing a reliable platform for siRNA delivery. At present, the commonly used inorganic nanocarriers include gold nanoparticles (AuNPs) [ 177 ], graphene oxide (GO) [ 178 ], carbon nanotubes [ 179 ], and mesoporous silica [ 180 ].…”

Section: Sirna Nanocarriersmentioning

confidence: 99%

Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review

Tong

Liu

Cao

et al. 2023

IJMS

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Gene therapy has attracted much attention because of its unique mechanism of action, non-toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues. siRNA-based gene therapy can downregulate, enhance, or correct gene expression by introducing some nucleic acid into patient tissues. Routine treatment of hemophilia requires frequent intravenous injections of missing clotting protein. The high cost of combined therapy causes most patients to lack the best treatment resources. siRNA therapy has the potential of lasting treatment and even curing diseases. Compared with traditional surgery and chemotherapy, siRNA has fewer side effects and less damage to normal cells. The available therapies for degenerative diseases can only alleviate the symptoms of patients, while siRNA therapy drugs can upregulate gene expression, modify epigenetic changes, and stop the disease. In addition, siRNA also plays an important role in cardiovascular diseases, gastrointestinal diseases, and hepatitis B. However, free siRNA is easily degraded by nuclease and has a short half-life in the blood. Research has found that siRNA can be delivered to specific cells through appropriate vector selection and design to improve the therapeutic effect. The application of viral vectors is limited because of their high immunogenicity and low capacity, while non-viral vectors are widely used because of their low immunogenicity, low production cost, and high safety. This paper reviews the common non-viral vectors in recent years and introduces their advantages and disadvantages, as well as the latest application examples.

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“…Glioma is considered to be one of the most malignant tumors with poor prognosis (Wang et al, 2022 ). Most patients survived less than 15 months after being diagnosed.…”

Section: Introductionmentioning

confidence: 99%

Transferrin receptor targeting segment T7 containing peptide gene delivery vectors for efficient transfection of brain tumor cells

Kang¹,

Zeng²,

Tian

et al. 2022

Drug Delivery

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Successful gene therapy for brain tumors are often limited by two important factors, the existence of blood brain barrier (BBB) and inefficient transfection of brain tumor cells. In this study, we designed a series of peptide-based gene delivery vectors decorated with T7 segment for binding the transferrin (Tf) receptors which were highly expressed on brain tumor cells, and evaluated their ability of gene delivery. The physicochemical properties of peptide vectors or peptide/DNA complexes were studied as well. The in vitro transfection efficiency was investigated in normal and glioma cell lines. Among these complexes, PT-02/DNA complexes showed the highest transfection efficiency in glioma cells and low cytotoxicity in normal cell lines, and it could transport DNA across the BBB model in vitro . Furthermore, PT-02/DNA could deliver pIRES2-EGFP into the brain site of zebrafish in vivo . The designed peptide vectors offered a promising way for glioma gene therapy.

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The Role of Graphene Oxide Nanocarriers in Treating Gliomas

Cited by 11 publications

References 160 publications

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Promising Therapeutic Strategies for Colorectal Cancer Treatment Based on Nanomaterials

Research Status and Prospect of Non-Viral Vectors Based on siRNA: A Review

Transferrin receptor targeting segment T7 containing peptide gene delivery vectors for efficient transfection of brain tumor cells

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