The role of gonadotrophins in gonocyte transformation during minipuberty

Burton, Emily; Abeydeera, Sanduni Amaya; Sarila, Gulcan; Cho, Hyun Jung; Wu, Shengde; Tien, Melissa Yixin; Hutson, John M.; Li, Ruili

doi:10.1007/s00383-020-04737-6

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Follicle stimulating hormone ( FSH ) and luteinizing hormone ( LH ) regulate the concentration of testosterone directly or indirectly and affect the initiation of the mitotic and meiotic cycles of spermatogonial cells in spermatogenic tubules. 20 Therefore, exogenous supplementation with a sufficient amount of endogenous hormones or inhibition of their degradation rate should effectively regulate spermatogenesis. However, long‐term clinical observations have shown that high concentrations of testosterone also inhibit spermatogenesis, 21 , 22 which is most common in patients undergoing testosterone replacement therapy.…”

Section: Resultsmentioning

confidence: 99%

“…Testosterone ( T ) is considered an endogenous driving force that directly enhances spermatogenesis. Follicle stimulating hormone ( FSH ) and luteinizing hormone ( LH ) regulate the concentration of testosterone directly or indirectly and affect the initiation of the mitotic and meiotic cycles of spermatogonial cells in spermatogenic tubules 20 . Therefore, exogenous supplementation with a sufficient amount of endogenous hormones or inhibition of their degradation rate should effectively regulate spermatogenesis.…”

Section: Resultsmentioning

confidence: 99%

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Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review

Liu

Luo²,

Chen

et al. 2022

Health Science Reports

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Background and Aims Cryptozoospermia is an extreme oligozoospermia with an unsatisfactory treatment effect, with an incidence rate of approximately 8.73% in male infertility, whose effective solution has become the call of the times. Western Medicine has achieved certain effects through drugs, surgery, and assisted reproductive therapy, but this is still not ideal. Traditional Chinese medicine ( TCM ) has made many achievements in other disciplines; however, there is still a lack of evidence‐based medical evidence to improve sperm production. Methods The relevant literatures from the China National Knowledge Internet ( CNKI ) and PubMed in the past 10 years were collected in this article, of which the mechanisms, advantages, or current controversies of various treatment methods of Western Medicine and TCM were analyzed, to find new treatment methods and research directions. Results With the development of modern science and technology, medical treatments for cryptozoospermia have become increasingly abundant; however, there is still no universally recognized unified and effective guiding plan. Although TCM has not been fully verified by evidence‐based medicine, most TCM combined with Western Medicine can achieve unexpected results. Conclusion The combination of TCM and Western Medicine may become a bane for cryptozoospermia and bring good news to infertile men worldwide.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%