The role of GLUT2 in dietary sugar handling

Leturque, Armelle; Brot-Laroche, Édith; Gall, Maude Le; Stolarczyk, Émilie; Tobin, Vanessa

doi:10.1007/bf03168378

Cited by 87 publications

(72 citation statements)

References 44 publications

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“…The second major fructose transporter is GLUT2, a low-affinity transporter that is also capable of recognizing glucose and galactose, and is inhibitable by phloretin and cytochalasin B (97). GLUT2 in a bidirectional manner is involved mainly in fructose uptake across the hepatic plasma membrane into the liver (154) and in the basolateral membrane of the intestinal and renal epithelial cells (88). Five other GLUTs may possess varying degrees of fructose selectivity based on sequence homology with GLUT5: GLUT7, GLUT9a/b, GLUT8, GLUT11, and GLUT12 (43,90,96).…”

Section: The Main Fructose Transporter Glut5mentioning

confidence: 99%

Regulation of the fructose transporter GLUT5 in health and disease

Douard¹,

Ferraris²

2008

American Journal of Physiology-Endocrinology and Metabolism

392

366

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Fructose is now such an important component of human diets that increasing attention is being focused on the fructose transporter GLUT5. In this review, we describe the regulation of GLUT5 not only in the intestine and testis, where it was first discovered, but also in the kidney, skeletal muscle, fat tissue, and brain where increasing numbers of cell types have been found to have GLUT5. GLUT5 expression levels and fructose uptake rates are also significantly affected by diabetes, hypertension, obesity, and inflammation and seem to be induced during carcinogenesis, particularly in the mammary glands. We end by highlighting research areas that should yield information needed to better understand the role of GLUT5 during normal development, metabolic disturbances, and cancer.

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Section: The Main Fructose Transporter Glut5mentioning

confidence: 99%

Regulation of the fructose transporter GLUT5 in health and disease

Douard¹,

Ferraris²

2008

American Journal of Physiology-Endocrinology and Metabolism

392

366

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“…GLUT2 in a bidirectional manner is involved mainly in fructose uptake across the basolateral membrane of the intestinal and renal epithelial cells (14) after apical transport mediated by GLUT5, fructose is transported across the basolateral membrane by GLUT2 (Fig. 2).…”

Section: Introductionmentioning

confidence: 99%

Fructose transporter Glut5 expression in clear renal cell carcinoma

Villaamil

Gallego²,

Rubira³

et al. 2011

Oncol Rep

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Abstract. Renal cell carcinomas (RCC) can be subclassified for general purposes into clear cell, papillary cell, chromophobe cell carcinomas and oncocytomas. Other tumours such as collecting duct, medullary, mucinous tubular and spindle cell and associated with Xp 11.2 translocations/TFE 3 gene fusion, are much less common. There is also a residual group of unclassified cases. Previous studies have shown that RCC has high glycolytic rates, and expresses GLUT transporters, but no distinction has been made among the different subtypes of renal cell tumours and their grades of malignancy. In clear renal cell carcinoma (cRCC) glycogen levels increase, glycolysis is activated and gluconeogenesis is reduced. The clear cell subtype of RCC is characterized histologically by a distinctive pale, glassy cytoplasm and this appearance of cRCC is due to abnormalities in carbohydrate and lipid metabolism, and this abnormality results in glycogen and sterol storage. Several isoforms of glucose carriers (GLUTs) have been identified. We show here in a panel of 80 cRCC samples a significant correlation between isoform 5 (GLUT5) and many pathological parameters such as grade of differentiation, pelvis invasion and breaking capsule. GLUT5 expression also appears to associate more strongly with the clear cell RCC subtype. These data suggest a role for the GLUT5 isoform in fructose uptake that takes place in cRCC cells and which subsequently leads to the malignant RCC progression.

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“…The accumulated sugars in enterocytes are subsequently released into the capillaries via the facilitated transporters, GLUT2 and GLUT5, localized on the basolateral surface of the cells. However, there is an increasing evidence showing that GLUT2 may also mediate a diffusive component of intestine glucose absorption in the brush-border membrane [89,90]. Mutations of SGLT1 have been linked to a major defect in glucose and galactose absorption [91], but both a GLUT2-deficient patient [92] and GLUT2-null mice [93] displayed normal intestinal monosaccharide transport kinetics, suggesting the presence of a membrane traffic-based pathway in intestinal sugar absorption.…”

Section: Roles Of Glucose Transporters In Differ-ent Physiological Prmentioning

confidence: 99%

Functional Properties and Genomics of Glucose Transporters

Zhao

Keating²

2007

481

393

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Glucose is the major energy source for mammalian cells as well as an important substrate for protein and lipid synthesis. Mammalian cells take up glucose from extracellular fluid into the cell through two families of structurallyrelated glucose transporters. The facilitative glucose transporter family (solute carriers SLC2A, protein symbol GLUT) mediates a bidirectional and energy-independent process of glucose transport in most tissues and cells, while the Na + /glucose cotransporter family (solute carriers SLC5A, protein symbol SGLT) mediates an active, Na + -linked transport process against an electrochemical gradient. The GLUT family consists of thirteen members (GLUT1-12 and HMIT). Phylogenetically, the members of the GLUT family are split into three classes based on protein similarities. Up to now, at least six members of the SGLT family have been cloned (SGLT1-6). In this review, we report both the genomic structure and function of each transporter as well as intra-species comparative genomic analysis of some of these transporters. The affinity for glucose and transport kinetics of each transporter differs and ranges from 0.2 to 17mM. The ability of each protein to transport alternative substrates also differs and includes substrates such as fructose and galactose. In addition, the tissue distribution pattern varies between species. There are different regulation mechanisms of these transporters. Characterization of transcriptional control of some of the gene promoters has been investigated and alternative promoter usage to generate different protein isoforms has been demonstrated. We also introduce some pathophysiological roles of these transporters in human.

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The role of GLUT2 in dietary sugar handling

Cited by 87 publications

References 44 publications

Regulation of the fructose transporter GLUT5 in health and disease

Regulation of the fructose transporter GLUT5 in health and disease

Fructose transporter Glut5 expression in clear renal cell carcinoma

Functional Properties and Genomics of Glucose Transporters

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