The role of glucocorticoids for spiral ganglion neuron survival

Jin, David X.; Lin, Zhaoyu; Lei, Debin; Bao, Jianxin

doi:10.1016/j.brainres.2009.02.017

Cited by 18 publications

(18 citation statements)

References 110 publications

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“…High doses of MDMA also cause neurotoxicity through increased glutamate levels (Sarkar & Schmued, 2010), oxidative stress (Fiaschi & Cerretani, 2010; Sarkar & Schmued, 2010), and ischemia/vasoconstriction (Baker et al, 2007; Bingham et al, 1998). Similarly, NIHL is associated with neural toxicity from reduced adenosine levels (Vlajkovic et al, 2009), reduced nicotinic acetylcholinergic activity (Elgoyhen et al, 2009), reduced glucocorticoid receptor activity (Jin et al, 2009), increased glutamate release (Le Prell et al, 2007), oxidative stress (Le Prell et al, 2007), ischemia in the stria vascularis (Le Prell et al, 2007), and serotonin and dopamine depletion (Lendvai et al, 2011; Papesh & Hurley, 2012; Tong et al, 2005). …”

Section: Discussionmentioning

confidence: 99%

‘Ecstasy’ enhances noise-induced hearing loss

et al. 2013

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‘Ecstasy’ or 3,4-methylenedioxy-N-methamphetamine (MDMA) is an amphetamine abused for its euphoric, empathogenic, hallucinatory, and stimulant effects. It is also used to treat certain psychiatric disorders. Common settings for Ecstasy use are nightclubs and “rave” parties where participants consume MDMA and dance to loud music. One concern with the club setting is that exposure to loud sounds can cause permanent sensorineural hearing loss. Another concern is that consumption of MDMA may enhance such hearing loss. Whereas this latter possibility has not been investigated, this study tested the hypothesis that MDMA enhances noise-induced hearing loss (NIHL) by exposing rats to either MDMA, noise trauma, both MDMA and noise, or neither treatment. MDMA was given in a binge pattern of 5 mg/kg per intraperitoneal injections every 2 h for a total of four injections to animals in the two MDMA-treated groups (MDMA-only and Noise+MDMA). Saline injections were given to the animals in the two non-MDMA groups (Control and Noise-only). Following the final injection, noise trauma was induced by a 10 kHz tone at 120 dB SPL for 1 h to animals in the two noise trauma-treated groups (Noise-only and Noise+MDMA). Hearing loss was assessed by the auditory brainstem response (ABR) and cochlear histology. Results showed that MDMA enhanced NIHL compared to Noise-only and that MDMA alone caused no hearing loss. This implies that “clubbers” and “rave-goers” are exacerbating the amount of NIHL when they consume MDMA and listen to loud sounds. In contrast to earlier reports, the present study found that MDMA by itself caused no changes in the click-evoked ABR’s wave latencies or amplitudes.

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Section: Discussionmentioning

confidence: 99%

‘Ecstasy’ enhances noise-induced hearing loss

et al. 2013

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“…It was manifested that high concentration of glucocorticoids (GC) can change the biological properties of neurons' plasma membrane, which results in impaired ions movement cycle across the cell membrane and deficiencies of nerve impulse transmission (22). Given that rats exposed to prenatal stress have a higher level of basic GC (5), there is a possibility that their neuronal function is impaired and thus the action potential transmission time is increased (22). Previous research has also reported the malfunction of different parts of the central nervous system (CNS) in animals exposed to prenatal stress (22).…”

Section: Discussionmentioning

confidence: 99%

“…Given that rats exposed to prenatal stress have a higher level of basic GC (5), there is a possibility that their neuronal function is impaired and thus the action potential transmission time is increased (22). Previous research has also reported the malfunction of different parts of the central nervous system (CNS) in animals exposed to prenatal stress (22). During the aging process, similar to prenatal stress exposure, malfunction of HPA axis and rising the basic level of GC in blood can occur (23).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Prenatal Stress on Auditory Brainstem Responses in Rat Pups

et al. 2018

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Background: Recent epidemiological evidence indicates that the fetal environment can influence susceptibility to later disease during the lifespan. Prenatal stress exposure alters the programming of the metabolic and endocrine balance of various organs, including the auditory system. Objectives: The current study aimed at evaluating how prenatal stress influences Auditory Brainstem Responses. Methods: Eighteen pregnant Wistar rats were stressed during a one-month gestation by chronic mild stress (CMS, a variable schedule of different stressors). After birth, the offspring's hearing thresholds and latencies were evaluated and compared with the control group. The hearing thresholds were assessed by recording auditory evoked brainstem responses to 4, 8,12, and 16 kHz tone burst. Results:The results showed that although CMS caused a significant increase in corticosterone in pregnant mothers, the offspring with CMS experience had significantly lower body weight than control animals (P < 0.00) yet there was no difference between hearing sensitivity of prenatally stressed offspring and the control group. However, ABRs showed a marked prolongation in wave II and IV latencies in prenatally stressed rats (P < 0.05). Conclusion:The current data confirmed that prenatal exposure to mild stress is not detrimental to hearing sensitivity. However, these data suggest that prenatal stress can affect the temporal processing of auditory stimuli in the brainstem.

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“…The ability of GCs to reduce NIHL has been demonstrated in various animal models (for recent reviews see Jin et al, 2009; Trune and Canlon, 2012). However, GCs are known to cause serious dose-dependent side effects, including psychosis, gastritis, hypertension, insulin resistance, sleep disturbances, and aseptic necrosis of the hip (Hanaoka et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss

et al. 2013

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Noise is the most common occupational and environmental hazard. Noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit, after age-related hearing loss (presbycusis). Although promising approaches have been identified for reducing NIHL, currently there are no effective medications to prevent NIHL. Development of an efficacious treatment has been hampered by the complex array of cellular and molecular pathways involved in NIHL. We turned this difficulty into an advantage by asking whether NIHL could be effectively prevented by targeting multiple signaling pathways with a combination of drugs already approved by U.S. Food and Drug Administration (FDA). We previously found that antiepileptic drugs blocking T-type calcium channels had both prophylactic and therapeutic effects for NIHL. NIHL can also be reduced by an up-regulation of glucocorticoid (GC) signaling pathways. Based on these findings, we tested a combination therapy for NIHL that included ethosuximide and zonisamide (anticonvulsants) and dexamethasone and methylprednisolone (synthetic GCs) in mice under exposure conditions typically associated with dramatic permanent threshold shifts (PTS). We first examined possible prophylactic effects for each drug when administered alone two hours before noise, and calculated the median effective dose (ED50). We then tested for synergistic effects of two-drug combinations (anticonvulsant + GC), and identified combinations with the strongest synergy against NIHL, based on a previously established combination index (CI) metric. We repeated similar tests to determine their therapeutic effects when administered the same drugs 24 hours after the noise exposure. Our study shows the feasibility of developing pharmacological intervention in multiple pathways, and discovering drug combinations with optimal synergistic effects in preventing permanent NIHL.

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The role of glucocorticoids for spiral ganglion neuron survival

Cited by 18 publications

References 110 publications

‘Ecstasy’ enhances noise-induced hearing loss

‘Ecstasy’ enhances noise-induced hearing loss

The Effect of Prenatal Stress on Auditory Brainstem Responses in Rat Pups

Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss

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