The role of ginger’s extract and N-acetylcysteine against docetaxel-induced oxidative stress and genetic disorder

Motafeghi, Farzaneh; Mortazavi, Parham; Mahiny, Amir Hossein Salman; Abtahi, Mohammad Mehdi; Shokrzadeh, Mohammad

doi:10.1080/01480545.2022.2075377

Cited by 10 publications

(1 citation statement)

References 47 publications

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“…Since CO-mediated inhibition of mitochondrial oxidative metabolism can increase the amount of mitochondrial (mt) ROS, a typical phenotype observed with an impaired ETC in cancer cells [23], we measured ROS in mitochondrial extracts and thiobarbituric reactive substances (TBARS), i.e., lipoperoxidation products that indicate the presence of oxidative stress. Compound 1 increased both mtROS and mtTBARS, whereas cisplatin, doxorubicin, gemcitabine, and docetaxel are devoid of effects, although they have been reported to induce oxidative stress in sensitive cells [31][32][33][34] (Figure 6A,B, Supplementary Figure S3A,B). A similar increase in ROS and lipoperoxidation was observed in whole cell lysates (Figure 6C,D, Supplementary Figure S3C,D).…”

Section: Corm-induced Chemosensitization Is Caused By Increased Oxida...mentioning

confidence: 99%

Use of Enzymatically Activated Carbon Monoxide Donors for Sensitizing Drug-Resistant Tumor Cells

Sodano

Rolando

Lazzarato

et al. 2023

IJMS

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The application of gaseous signaling molecules like NO, H2S or CO to overcome the multidrug resistance in cancer treatment has proven to be a viable therapeutic strategy. The development of CO-releasing molecules (CORMs) in a controlled manner and in targeted tissues remains a challenge in medicinal chemistry. In this paper, we describe the design, synthesis and chemical and enzymatic stability of a novel non-metal CORM (1) able to release intracellularly CO and, simultaneously, facilitate fluorescent degradation of products under the action of esterase. The toxicity of 1 against different human cancer cell lines and their drug-resistant counterparts, as well as the putative mechanism of toxicity were investigated. The drug-resistant cancer cell lines efficiently absorbed 1 and 1 was able to restore their sensitivity vs. chemotherapeutic drugs by causing a CO-dependent mitochondrial oxidative stress that culminated in mitochondrial-dependent apoptosis. These results demonstrate the importance of CORMs in cases where conventional chemotherapy fails and thus open the horizons towards new combinatorial strategies to overcome multidrug resistance.

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