The role of genotoxicity in asbestos-induced mesothelioma: an explanation for the differences in carcinogenic potential among fiber types

Barlow, Christy A.; Lievense, Laura; Gross, Sherilyn A.; Ronk, Christopher J.; Paustenbach, Dennis J.

doi:10.3109/08958378.2013.807321

Cited by 18 publications

(17 citation statements)

References 133 publications

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“…The mechanism(s) underlying asbestos toxicity associated with the pathogenesis of mesothelioma has been a challenge to unravel for more than six decades [33]. According to our results and the current knowledge about asbestos-induced carcinomas, we speculate about a model that explains a potential path leading to carcinomas.…”

Section: Sepiolite Interacts With the Dna By Causing Double-strand Brmentioning

confidence: 50%

“…Overall, one of the most significant contributions of this article is the proposition for the first time of a bacterial model to test genotoxicity of nanofibres and uncover a new mechanism of action for asbestos that correlates better with in vivo observations. Asbestosis is a global health and environmental problem, which molecular basis has been a challenge for several decades [33]. Although asbestos fibres are widely distributed in the anatomy of patients [33,50], the most common cancers caused by asbestos originate in lungs (mostly mesothelioma).…”

Section: Discussionmentioning

confidence: 99%

“…Asbestosis is a global health and environmental problem, which molecular basis has been a challenge for several decades [33]. Although asbestos fibres are widely distributed in the anatomy of patients [33,50], the most common cancers caused by asbestos originate in lungs (mostly mesothelioma). If the most explored mechanism of action is based on reactive radicals (chemical damage), why is not there significant differences in the frequencies of other types of carcinoma such as leukaemia, lymphoma, liver or kidney cancer among exposed populations?…”

Section: Discussionmentioning

confidence: 99%

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Clay-induced DNA double-strand breaks underlay genetic diversity, antibiotic resistance and could be a molecular basis for asbestos-induced cancer

González-Tortuero

Rodríguez-Beltrán

Radek

et al. 2017

Preprint

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Some natural clays and synthetic nanofibres present in the environment have a severe impact on human health. After several decades of research, the molecular mechanism of how asbestos induce cancers is not well understood. Different fibres, including asbestos, can penetrate the membrane and introduce DNA in both, bacterial and eukaryotic cells. Incubating Escherichia coli with sepiolite, a clayey material, and asbestos under friction forces, both fibres cause double-strand breaks in bacteria. Since antibiotics and clays are used together in animal husbandry, the mutagenic effect of these fibres might constitute a pathway to antibiotic resistance due to the friction provided by peristalsis of the gut from farm animals in addition to the previously proposed horizontal gene transfer. Moreover, we raise the possibility that the same mechanism could generate bacteria diversity in natural scenarios with a role in the evolution of species. Finally, we provide a new model on how asbestos may promote mutagenesis and cancer based on the observed mechanical genotoxicity.

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Section: Sepiolite Interacts With the Dna By Causing Double-strand Brmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clay-induced DNA double-strand breaks underlay genetic diversity, antibiotic resistance and could be a molecular basis for asbestos-induced cancer

González-Tortuero

Rodríguez-Beltrán

Radek

et al. 2017

Preprint

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“…( 15 ) In addition to eliciting this inflammatory response, asbestos can generate reactive oxygen and nitrogen species, which lead to DNA structure damage and induce genotoxicity, thus favoring the development of MM. ( 16 , 17 )…”

Section: Introductionmentioning

confidence: 99%

“…( 15 ) Além dessa resposta inflamatória, o amianto é capaz de gerar espécies reativas de oxigênio e de nitrogênio, as quais levam a danos na estrutura do DNA, induzido assim a genotoxicidade e favorecendo o desenvolvimento do mesmo. ( 16 , 17 )…”

Section: Introductionunclassified

Overview of the biochemical and genetic processes in malignant mesothelioma

Assis

Isoldi

2014

J. bras. pneumol.

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Malignant mesothelioma (MM) is a highly aggressive form of cancer, has a long latency period, and is resistant to chemotherapy. It is extremely fatal, with a mean survival of less than one year. The development of MM is strongly correlated with exposure to asbestos and erionite, as well as to simian virus 40. Although various countries have banned the use of asbestos, MM has proven to be difficult to control and there appears to be a trend toward an increase in its incidence in the years to come. In Brazil, MM has not been widely studied from a genetic or biochemical standpoint. In addition, there have been few epidemiological studies of the disease, and the profile of its incidence has yet to be well established in the Brazilian population. The objective of this study was to review the literature regarding the processes of malignant transformation, as well as the respective mechanisms of tumorigenesis, in MM.

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Serpentine and Amphibole Asbestos [A Subset of Elongated Mineral Particles (EMPs)]

“Tony” Havics,

Bernstein

2024

Patty's Toxicology

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The term asbestos refers to two very different minerals, serpentine and amphibole, occurring in fibrous form with very different mineralogical properties. Unfortunately, the term “asbestos” has been used loosely when, in fact, it has always been appropriate to discuss them separately. This chapter focuses on the key essential differences which result in very different toxicological and epidemiological responses to the fibers from these two minerals. In particular, it is discussed how a fiber's potency dictates the health risk, how the fiber's mineralogy affects biopersistence in the lung, and how fiber length determines how the lung responds to this characteristic. The differential toxicology is presented, as well as the epidemiology of these fibrous minerals. The regulations in the United Stated are also discussed. It is now convenient to use the term asbestos to describe a subset of elongated mineral particles (EMPs). Although the term has been discussed with potential differing definitions depending on the authors' purpose from 1979 to 2023, a popular working definition for EMPs is any mineral particle with a minimum aspect ratio of 3:1. This chapter will focus on the asbestos subset.

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The role of genotoxicity in asbestos-induced mesothelioma: an explanation for the differences in carcinogenic potential among fiber types

Cited by 18 publications

References 133 publications

Clay-induced DNA double-strand breaks underlay genetic diversity, antibiotic resistance and could be a molecular basis for asbestos-induced cancer

Clay-induced DNA double-strand breaks underlay genetic diversity, antibiotic resistance and could be a molecular basis for asbestos-induced cancer

Overview of the biochemical and genetic processes in malignant mesothelioma

Serpentine and Amphibole Asbestos [A Subset of Elongated Mineral Particles (EMPs)]

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