The attempt to solve multimorbidity using tools of the biological framework makes us return to the origin: It is like a boomerang. Doctor is punished to strive uphill on a mountain to climb the heavy burden of multimorbidity when it seems to be reaching the top that burden of disease rolls back down, and again, the doctor is at the point of departure and that seems to be repeated infinitely: It is like the Myth of Sisyphus. Diagnosis and medical treatment are the "weapons" used by the professional to "cure" or "solve" health problems. However, overdiagnosis and drug overtreatment are weapons that, if they do not impact their objective, return to their point of origin, creating more problems than they intended to solve overdiagnosis and polypharmacy. Of every 100 courses of drug treatment, there are 20 adverse drug reactions, between 5 and 25 of clinically observable drug-drug interactions (DDIs) and between 15 and 50 potential DDIs, which arrive to 100 in geriatric patients. The current approach to the disease, risk factors, and prevention, within the biomedical framework, seems to produce a boomerang effect or Sisyphus effect. However, it is even worse: It is a logarithmic spiral or "the wonderful spiral" or "growth spiral." This spiral follows a geometric progression, not arithmetic: Every health problem that we "cure" leads us, not to another new problem, but to many more. And so, it is increasingly complex to leave the labyrinth of multimorbidity and polytherapy. And yet, the DDIs are often predictable and preventable, and the biomedical framework for addressing health problems can be extended to a biopsychosocial framework.