The role of GABAergic transmission in the dentate gyrus on acquisition, consolidation and retrieval of an inhibitory avoidance learning and memory task in the rat

Shahidi, Siamak; Komaki‬, Alireza; Mahmoodi, Minoo; Lashgari, Reza

doi:10.1016/j.brainres.2008.02.008

Cited by 33 publications

(10 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PA apparatus and procedure were similar to those used in our previous studies [28-33]. Briefly, the apparatus had light and dark compartments which were connected to each other by a guillotine opaque door.…”

Section: Methodsmentioning

confidence: 99%

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

2018

Self Cite

View full text Add to dashboard Cite

Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and inflammatory markers, and improve vascular function. Therefore, the aim of the present study was to investigate the possible effects of CoQ10 on cognitive function, learning, and memory in middle-aged healthy and diabetic rats. Adult middle-aged male Wistar rats (390–460 g, 12–13 months old) were divided into 6 experimental groups. Diabetes was induced by a single i.p. injection of streptozotocin (60 mg/kg). CoQ10 (20 or 120 mg/kg, orally by gavage) was administered for 45 days. The cognitive function and learning memory of rats were evaluated using novel object recognition (NOR) and passive avoidance tests. The discrimination index of the NOR test in the diabetic groups receiving CoQ10 (20 or 120 mg/kg) and the healthy group receiving CoQ10 (120 mg/kg) was significantly higher than that in the control group. In addition, the step through latency was significantly longer and the time spent in the dark compartment was significantly shorter in the diabetic groups receiving CoQ10 than in the control group. CoQ10 supplementation can improve learning and memory deficits induced by diabetes in older subjects. In addition, CoQ10 at higher doses can improve cognitive performance in older healthy subjects.

show abstract

Section: Methodsmentioning

confidence: 99%

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…The rat was placed in the illuminated enclosure facing away from the guillotine door, and 5 s later the door was raised. After the rat had entered the dark part, the door was closed, and a 50 Hz square wave, 1.2 mA constant current shock was applied for 1.5 s.[222324252627] The rat was retained in the apparatus and received a foot shock each time it reentered the dark part. Training was terminated when the rat remained in the illuminated enclosure for 120 consecutive s. On the retention test that given 24 and 48 h after the acquisition trial, the rat was again placed into the illuminated part and step-through latency (STLr) latency and time spent in the dark compartment (TDC) were recorded as a measure of retention performance.…”

Section: Methodsmentioning

confidence: 99%

Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats

et al. 2015

Self Cite

View full text Add to dashboard Cite

Background:Medicinal plants, owing to their different mechanisms such as antioxidants effects, may improve learning and memory impairments in diabetic rats. Calendula officinalis (CO), has a significant antioxidant activity.Aims:To examine the effect of hydroalcoholic extract of CO on passive avoidance learning (PAL) and memory in streptozotocin (STZ)-induced diabetic male rats.Settings and Design:A total of 32 adult male Wistar rats were randomly allocated to four groups: Control, diabetic, control + extract of CO and diabetic control + extract of CO groups with free access to regular rat diet.Subjects and Methods:Diabetes in diabetic rats was induced by single intraperitoneal injection of 60 mg/kg STZ. After confirmation of diabetes, oral administration of 300 mg/kg CO extract to extract-treated groups have been done. PAL was tested 8 weeks after onset of treatment, and blood glucose and body weight were measured in all groups at the beginning and end of the experiment.Statistical Analysis Used:The statistical analysis of data was performed by ANOVA followed by least significant difference post-hoc analysis.Results:Diabetes decreased learning and memory. Effect of CO extract in retention test (after 24 and 48 h) has been shown a significant decrease in step-through latency and increase in time spent in the dark compartment part. Also the extract partially improved hyperglycemia and reduced body weight.Conclusion:Taken together, CO extract can improve PAL and memory impairments in STZ-diabetic rats. This improvement may be due to its antioxidant, anticholinergic activities or its power to reduce hyperglycemia.

show abstract

“…When each rat was placed in the light compartment with its back to the guillotine door, the door was opened, and, at the same time, the time (the step-through latency) was measured with a stopwatch until the rat entered the dark compartment. After the rat entered the dark compartment, the door was closed (Shahidi et al, 2008;Lashgari et al, 2009;Rasuli et al, 2011;Sarihi et al, 2011).…”

Section: Apparatus and Proceduresmentioning

confidence: 99%

“…The habituation trial was repeated after 30 min. It was followed after the same interval by the acquisition trial, during which the guillotine door was closed, and a 50-Hz 1-mA constant current shock was applied for 1.5 s immediately after the animal had entered the dark compartment (Shahidi et al, 2008;Lashgari et al, 2009;Rasuli et al, 2011;Sarihi et al, 2011). In the experiment, the rat was retained in the apparatus, and it received a foot shock each time it reentered the dark compartment.…”

Section: Training Proceduresmentioning

confidence: 99%

Effects of cannabinoid and glutamate receptor antagonists and their interactions on learning and memory in male rats

Barzegar

Komaki‬

Shahidi

et al. 2015

Pharmacology Biochemistry and Behavior

Self Cite

View full text Add to dashboard Cite

The role of GABAergic transmission in the dentate gyrus on acquisition, consolidation and retrieval of an inhibitory avoidance learning and memory task in the rat

Cited by 33 publications

References 57 publications

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats

Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats

Effects of cannabinoid and glutamate receptor antagonists and their interactions on learning and memory in male rats

Contact Info

Product

Resources

About